The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Self-Propelled Polymer Multilayer Janus Capsules for Effective Drug Delivery and Light-Triggered Release
Abstract
We present herein a novel hybrid, polymer-based motor that was fabricated by the template-assisted polyelectrolyte layer-by-layer (LbL) deposition of a thin gold layer on one side, followed by chemical immobilization of a catalytic enzyme. Such Janus capsule motors can self-propel at 0.1% peroxide fuel concentration at physiological temperature and have a higher speed as compared to Pt-based synthetic motors. They were exploited for encapsulation of the chemotherapeutic anticancer drug, doxorubicin, for navigation to target a cell layer by an external magnetic field, and for triggered drug release activated by NIR light. This work provides high potential in the development of multifunctional polymer-based engines for biomedical applications such as targeted drug delivery.
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Cites
Designing materials for biology and medicine
Langer, R., & Tirrell, D. A. (2004) · Nature · doi:10.1038/nature02388 · Cited by 3,198
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748
Design considerations for tumour-targeted nanoparticles
Choi, H. S., Liu, W., Liu, F., Nasr, K., Misra, P., Bawendi, M. G., & Frangioni, J. V. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.314 · Cited by 754
Cited by
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
Engineering microrobots for targeted cancer therapies from a medical perspective
Schmidt, C. K., Medina-Sánchez, M., Edmondson, R. J., & Schmidt, O. G. (2020) · Nature Communications · doi:10.1038/s41467-020-19322-7 · Cited by 441
Mimicking the Cell: Bio-Inspired Functions of Supramolecular Assemblies
Tu, Y., Peng, F., Adawy, A., Men, Y., Abdelmohsen, L. K. E. A., & Wilson, D. A. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00344 · Cited by 316
Janus particles: design, preparation, and biomedical applications
Su, H., Hurd Price, C.-A., Jing, L., Tian, Q., Liu, J., & Qian, K. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100033 · Cited by 285
Metadata
- Authors
- Wu, Y., Lin, X., Wu, Z., Möhwald, H., & He, Q.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-06-16
- Volume
- 6
- Issue
- 13
- Pages
- 10476-10481
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W1968544483
- Cited by
- 254
- References
- 3
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- closed
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