Cited by 113Hydrogels: synthesis, properties, applicationsSupramolecular Self-Assembly in MaterialsSupramolecular Chemistry and Complexes

Supramolecular Hybrid Hydrogel Based on Host–Guest Interaction and Its Application in Drug Delivery

Yu, Jing, Ha, Wei, Sun, Jian-nan, Shi, Yan-ping·2014·ACS Applied Materials & Interfaces

Abstract

In this work, we developed a simple, novel method for constructing gold nanocomposite supramolecular hybrid hydrogels for drug delivery, in which gold nanocrystals were utilized as building blocks. First, methoxypoly(ethylene glycol) thiol (mPEG-SH, molecular weight (MW)=5 K) capped gold nanocrystals (nanospheres and nanorods) were prepared via a facile one-step ligand-exchange procedure. Then, the homogeneous supramolecular hybrid hydrogels were formed, after adding α-cyclodextrin (α-CD) into PEG-modified gold nanocrystal solutions, due to the host-guest inclusion. Both gold nanoparticles and inclusion complexes formed between α-CD and PEG chain provided the supra-cross-links, which are beneficial to the gelation formation. The resulting hybrid hydrogels were fully characterized by a combination of techniques including X-ray diffraction, rheology studies, and scanning electron microscopy. Meanwhile, the hybrid hydrogel systems demonstrated unique reversible gel-sol transition properties at a certain temperature caused by the temperature-responsive reversible supramolecular assembly. The drug delivery applications of such hybrid hydrogels were further investigated in which doxorubicin was selected as a model drug for in vitro release, cytotoxicity, and intracellular release studies. We believe that the development of such hybrid hydrogels will provide new and therapeutically useful means for medical applications.

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Crossref · 10.1021/am505649q

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  • Microgels loaded with DOX showed anticancer activity against HeLa cells, and supramolecular hydrogels of α CD- and polyethylene-modified gold nanocrystals exhibited sustained drug release via host-guest interaction.

    “Microgels loaded with DOX showed anticancer activity against HeLa cells, and supramolecular hydrogels of α CD- and polyethylene-modified gold nanocrystals exhibited sustained drug release via host-guest interaction.253”

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Authors
Yu, J., Ha, W., Sun, J.-N., & Shi, Y.-P.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China
Corresponding author
Shi, Yan-ping
Venue
ACS Applied Materials & Interfaces
Published
2014-11-14
Volume
6
Issue
22
Pages
19544-19551
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W2333289708
Cited by
113
References
48
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 12 · 2020: 14 · 2019: 11 · 2018: 16 · 2017: 18 · 2016: 10 · 2015: 8 · 2014: 1
FWCI
5.63
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Applied Materials & Interfaces (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (21105106, 21375136)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
  • Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
Keywords
host-guest interactions, gold nanocrystals, gold nanorods, gold nanospheres, α-cyclodextrin, inclusion complexes, ligand exchange, drug delivery, doxorubicin release, intracellular drug release, cytotoxicity
MeSH terms
Doxorubicin, Gold, Humans, Microscopy, Electron, Scanning, Neoplasms, Polyethylene Glycols, X-Ray Diffraction, Drug Delivery Systems, Hydrogel, Polyethylene Glycol Dimethacrylate, alpha-Cyclodextrins, Nanoparticles

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