Supramolecular Hybrid Hydrogel Based on Host–Guest Interaction and Its Application in Drug Delivery
Abstract
In this work, we developed a simple, novel method for constructing gold nanocomposite supramolecular hybrid hydrogels for drug delivery, in which gold nanocrystals were utilized as building blocks. First, methoxypoly(ethylene glycol) thiol (mPEG-SH, molecular weight (MW)=5 K) capped gold nanocrystals (nanospheres and nanorods) were prepared via a facile one-step ligand-exchange procedure. Then, the homogeneous supramolecular hybrid hydrogels were formed, after adding α-cyclodextrin (α-CD) into PEG-modified gold nanocrystal solutions, due to the host-guest inclusion. Both gold nanoparticles and inclusion complexes formed between α-CD and PEG chain provided the supra-cross-links, which are beneficial to the gelation formation. The resulting hybrid hydrogels were fully characterized by a combination of techniques including X-ray diffraction, rheology studies, and scanning electron microscopy. Meanwhile, the hybrid hydrogel systems demonstrated unique reversible gel-sol transition properties at a certain temperature caused by the temperature-responsive reversible supramolecular assembly. The drug delivery applications of such hybrid hydrogels were further investigated in which doxorubicin was selected as a model drug for in vitro release, cytotoxicity, and intracellular release studies. We believe that the development of such hybrid hydrogels will provide new and therapeutically useful means for medical applications.
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Microgels loaded with DOX showed anticancer activity against HeLa cells, and supramolecular hydrogels of α CD- and polyethylene-modified gold nanocrystals exhibited sustained drug release via host-guest interaction.
“Microgels loaded with DOX showed anticancer activity against HeLa cells, and supramolecular hydrogels of α CD- and polyethylene-modified gold nanocrystals exhibited sustained drug release via host-guest interaction.253”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [253]
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- Authors
- Yu, J., Ha, W., Sun, J.-N., & Shi, Y.-P.
- Affiliations
- Chinese Academy of Sciences (CN)
- Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China
- Corresponding author
- Shi, Yan-ping
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-11-14
- Volume
- 6
- Issue
- 22
- Pages
- 19544-19551
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2333289708
- Cited by
- 113
- References
- 48
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 12 · 2020: 14 · 2019: 11 · 2018: 16 · 2017: 18 · 2016: 10 · 2015: 8 · 2014: 1
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21105106, 21375136)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
- Keywords
- host-guest interactions, gold nanocrystals, gold nanorods, gold nanospheres, α-cyclodextrin, inclusion complexes, ligand exchange, drug delivery, doxorubicin release, intracellular drug release, cytotoxicity
- MeSH terms
- Doxorubicin, Gold, Humans, Microscopy, Electron, Scanning, Neoplasms, Polyethylene Glycols, X-Ray Diffraction, Drug Delivery Systems, Hydrogel, Polyethylene Glycol Dimethacrylate, alpha-Cyclodextrins, Nanoparticles
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