CoChat
Sign Up
Cited by 363Hydrogels: synthesis, properties, applicationsSupramolecular Self-Assembly in MaterialsSupramolecular Chemistry and Complexes

Supramolecular engineering of hydrogels for drug delivery

Open access
Bernhard, Stéphane, Tibbitt, Mark W.·2021·Advanced Drug Delivery Reviews
DOI 10.1016/j.addr.2021.02.002
Open this paper in CoChat — free accountOpen PDF

Abstract

Supramolecular binding motifs are increasingly employed in the design of biomaterials. The ability to rationally engineer specific yet reversible associations into polymer networks with supramolecular chemistry enables injectable or sprayable hydrogels that can be applied via minimally invasive administration. In this review, we highlight two main areas where supramolecular binding motifs are being used in the design of drug delivery systems: engineering network mechanics and tailoring drug-material affinity. Throughout, we highlight many of the established and emerging chemistries or binding motifs that are useful for the design of supramolecular hydrogels for drug delivery applications.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.addr.2021.02.002

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 189

  1. S.A. Dugger, A. Platt, D.B. Goldstein, Drug development in the era of precision medicine, Nat. Rev. Drug Discov. 17 (2018) 183-196, https://doi.org/10.1038/ nrd.2017.226. · DOI · Paper page
  2. M.W. Tibbitt, J.E. Dahlman, R. Langer, Emerging frontiers in drug delivery, J. Am. Chem. Soc. 138 (2016) 704-717, https://doi.org/10.1021/jacs. 5b09974. · DOI
  3. B. Homayun, X. Lin, H.J. Choi, Challenges and recent progress in oral drug delivery systems for biopharmaceuticals, Pharmaceutics 11 (2019) 129, https://doi.org/10.3390/pharmaceutics11030129. · DOI
  4. G. Traverso, R. Langer, Perspective: special delivery for the gut, Nature 519 (2015) S19, https://doi.org/10.1038/519S19a. · DOI
  5. Q. Liu, M. Das, Y. Liu, L. Huang, Targeted drug delivery to melanoma, Adv. Drug Deliv. Rev. 127 (2018) 208-221, https://doi.org/10.1016/j. addr.2017.09.016. · DOI
  6. P. Kumari, B. Ghosh, S. Biswas, Nanocarriers for cancer-targeted drug delivery, J. Drug Target. 24 (2016) 179-191, https://doi.org/10.3109/ 1061186X.2015.1051049. · DOI
  7. K.A. Autio, R. Dreicer, J. Anderson, J.A. Garcia, A. Alva, L.L. Hart, M.I. Milowsky, E.M. Posadas, C.J. Ryan, R.P. Graf, R. Dittamore, N.A. Schreiber, J.M. Summa, H. Youssoufian, M.J. Morris, H.I. Scher, Safety and efficacy of BIND-014, a docetaxel nanoparticle targeting prostate-specific membrane antigen for patients with metastatic castration-resistant prostate cancer: a phase 2 clinical trial, JAMA Oncol. 4 (2018) 1344-1351, https://doi.org/ 10.1001/jamaoncol.2018.2168. · DOI
  8. L.K. Müller, J. Simon, S. Schöttler, K. Landfester, V. Mailänder, K. Mohr, Pre- coating with protein fractions inhibits nano-carrier aggregation in human blood plasma, RSC Adv. 6 (2016) 96495-96509, https://doi.org/10.1039/ c6ra17028e. · DOI
  9. S. Wilhelm, A.J. Tavares, Q. Dai, S. Ohta, J. Audet, H.F. Dvorak, W.C.W. Chan, Analysis of nanoparticle delivery to tumours, Nat. Rev. Mater. 1 (2016) 1-12, https://doi.org/10.1038/natrevmats.2016.14. · DOI · Paper page
  10. R.A. Petros, J.M. Desimone, Strategies in the design of nanoparticles for therapeutic applications, Nat. Rev. Drug Discov. 9 (2010) 615-627, https:// doi.org/10.1038/nrd2591. · DOI · Paper page
  11. L. Ilium, S.S. Davis, C.G. Wilson, N.W. Thomas, M. Frier, J.G. Hardy, Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape, Int. J. Pharm. 12 (1982) 135-146, https://doi.org/10.1016/0378-5173(82)90113-2. · DOI
  12. N. Thakur, B. Sharma, S. Bishnoi, S.K. Mishra, D. Nayak, A. Kumar, T.K. Sarma, Multifunctional inosine monophosphate coordinated metal-organic hydrogel: multistimuli responsiveness, self-healing properties, and separation of water from organic solvents, ACS Sustain. Chem. Eng. 6 (2018) 8659-8671, https://doi.org/10.1021/acssuschemeng.8b00963. · DOI
  13. J.D. Kretlow, L. Klouda, A.G. Mikos, Injectable matrices and scaffolds for drug delivery in tissue engineering, Adv. Drug Deliv. Rev. 59 (2007) 263-273, https://doi.org/10.1016/j.addr.2007.03.013. · DOI
  14. Q. Chen, C. Wang, X. Zhang, G. Chen, Q. Hu, H. Li, J. Wang, D. Wen, Y. Zhang, Y. Lu, G. Yang, C. Jiang, J. Wang, G. Dotti, Z. Gu, In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment, Nat. Nanotechnol. 14 (2019) 89-97, https://doi.org/10.1038/s41565-018-0319-4. · DOI
  15. R. Dimatteo, N.J. Darling, T. Segura, In situ forming injectable hydrogels for drug delivery and wound repair, Adv. Drug Deliv. Rev. 127 (2018) 167-184, https://doi.org/10.1016/j.addr.2018.03.007. · DOI
  16. N.A. Peppas, A.R. Khare, Preparation, structure and diffusional behavior of hydrogels in controlled release, Adv. Drug Deliv. Rev. 11 (1993) 1-35, https:// doi.org/10.1016/0169-409X(93)90025-Y. · DOI
  17. J.L. Ford, M.H. Rubinstein, J.E. Hogan, Propranolol hydrochloride and aminophylline release from matrix tablets containing hydroxypropylmethylcellulose, Int. J. Pharm. 24 (1985) 339-350, https:// doi.org/10.1016/0378-5173(85)90032-8. · DOI
  18. R.W. Korsmeyer, N.A. Peppas, Effect of the morphology of hydrophilic polymeric matrices on the diffusion and release of water soluble drugs, J. Memb. Sci. 9 (1981) 211-227, https://doi.org/10.1016/S0376-7388(00) 80265-3. · DOI
  19. N.B. Graham, M. Zulfiqar, B.B. MacDonald, M.E. McNeill, Caffeine release from fully swollen poly(ethylene oxide) hydrogels, J. Control. Release 5 (1987) 243-252, https://doi.org/10.1016/0168-3659(88)90023-5. · DOI
  20. S.J. Buwalda, K.W.M. Boere, P.J. Dijkstra, J. Feijen, T. Vermonden, W.E. Hennink, Hydrogels in a historical perspective: from simple networks to smart materials, J. Control. Release 190 (2014) 254-273, https://doi.org/ 10.1016/j.jconrel.2014.03.052. · DOI · Paper page
  21. J.L. Drury, D.J. Mooney, Hydrogels for tissue engineering: scaffold design variables and applications, Biomaterials 24 (2003) 4337-4351, https://doi. org/10.1016/S0142-9612(03)00340-5. · DOI · Paper page
  22. A.M. Mathur, S.K. Moorjani, A.B. Scranton, Methods for synthesis of hydrogel networks: a review, J. Macromol. Sci. -Rev. Macromol. Chem. Phys. 36 (1996) 405-430, https://doi.org/10.1080/15321799608015226. · DOI
  23. S.T. Koshy, T.C. Ferrante, S.A. Lewin, D.J. Mooney, Injectable, porous, and cell- responsive gelatin cryogels, Biomaterials 35 (2014) 2477-2487, https://doi. org/10.1016/j.biomaterials.2013.11.044. · DOI
  24. J.K. Oh, R. Drumright, D.J. Siegwart, K. Matyjaszewski, The development of microgels/nanogels for drug delivery applications, Prog. Polym. Sci. 33 (2008) 448-477, https://doi.org/10.1016/j.progpolymsci.2008.01.002. · DOI
  25. A. Paul, A. Hasan, H. Al Kindi, A.K. Gaharwar, V.T.S. Rao, M. Nikkhah, S.R. Shin, D. Krafft, M.R. Dokmeci, D. Shum-Tim, A. Khademhosseini, Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair, ACS Nano 8 (2014) 8050-8062, https:// doi.org/10.1021/nn5020787. · DOI
  26. S. Koutsopoulos, L.D. Unsworth, Y. Nagai, S. Zhang, Controlled release of functional proteins through designer self-assembling peptide nanofiber hydrogel scaffold, Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 4623-4628, https://doi.org/10.1073/pnas.0807506106. · DOI
  27. C. Wang, J. Wang, X. Zhang, S. Yu, D. Wen, Q. Hu, Y. Ye, H. Bomba, X. Hu, Z. Liu, G. Dotti, Z. Gu, In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy, Sci. Transl. Med. 10 (2018) 3682, https://doi.org/10.1126/scitranslmed.aan3682. · DOI
  28. M. Liu, X. Zeng, C. Ma, H. Yi, Z. Ali, X. Mou, S. Li, Y. Deng, N. He, Injectable hydrogels for cartilage and bone tissue engineering, Bone Res. 5 (2017) 1-20, https://doi.org/10.1038/boneres.2017.14. · DOI
  29. T.D. Johnson, K.L. Christman, Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction, Expert Opin. Drug Deliv. 10 (2013) 59-72, https://doi.org/10.1517/17425247.2013.739156. · DOI
  30. J.-M. Lehn, Supramolecular chemistry-scope and perspectives molecules, supermolecules, and molecular devices (nobel lecture), Angew. Chemie Int. Ed. English. 27 (1988) 89-112, https://doi.org/10.1002/anie.198800891. · DOI
  31. C.J. Pedersen, The discovery of crown ethers (noble lecture), Angew. Chemie Int. Ed. Eng. 27 (1988) 1021-1027, https://doi.org/10.1002/anie.198810211. · DOI
  32. D.J. Cram, The design of molecular hosts, guests, and their complexes (nobel lecture), Angew. Chemie Int. Ed. Engl. 27 (1988) 1009-1020, https://doi.org/ 10.1002/anie.198810093. · DOI
  33. M.J. Webber, E.A. Appel, E.W. Meijer, R. Langer, Supramolecular biomaterials, Nat. Mater. 15 (2015) 13-26, https://doi.org/10.1038/nmat4474. · DOI
  34. S. Mura, J. Nicolas, P. Couvreur, Stimuli-responsive nanocarriers for drug delivery, Nat. Mater. 12 (2013) 991-1003, https://doi.org/10.1038/nmat3776. · DOI · Paper page
  35. J. Li, D.J. Mooney, Designing hydrogels for controlled drug delivery, Nat. Rev. Mater. 1 (2016) 1-17, https://doi.org/10.1038/natrevmats.2016.71. · DOI
  36. V.J. Stella, V.M. Rao, E.A. Zannou, V. Zia, Mechanisms of drug release from cyclodextrin complexes, Adv. Drug Deliv. Rev. 36 (1999) 3-16, https://doi. org/10.1016/S0169-409X(98)00052-0. · DOI
  37. J. Li, C. Ji, X. Yu, M. Yin, D. Kuckling, Dually cross-linked supramolecular hydrogel as surface plasmon resonance sensor for small molecule detection, Macromol. Rapid Commun. 40 (2019) 1900189, https://doi.org/ 10.1002/marc.201900189. · DOI
  38. M. Guvendiren, H.D. Lu, J.A. Burdick, Shear-thinning hydrogels for biomedical applications, Soft Matter 8 (2012) 260-272, https://doi.org/10.1039/ c1sm06513k. · DOI
  39. S. Hou, X. Wang, S. Park, X. Jin, P.X. Ma, Rapid self-integrating, injectable hydrogel for tissue complex regeneration, Adv. Healthc. Mater. 4 (2015) 1491-1495, https://doi.org/10.1002/adhm.201500093. · DOI
  40. J.K. Sahoo, M.A. VandenBerg, M.J. Webber, Injectable network biomaterials via molecular or colloidal self-assembly, Adv. Drug Deliv. Rev. 127 (2018) 185-207, https://doi.org/10.1016/j.addr.2017.11.005. · DOI
  41. W.N.E. Van Dijk-Wolthuis, J.A.M. Hoogeboom, M.J. Van Steenbergen, S.K.Y. Tsang, W.E. Hennink, Degradation and release behavior of dextran-based hydrogels, Macromolecules 30 (1997) 4639-4645, https://doi.org/ 10.1021/ma9704018. · DOI
  42. Y. Chen, X.H. Pang, C.M. Dong, Dual stimuli-responsive supramolecular polypeptidebased hydrogel and reverse micellar hydrogel mediated by host- guest chemistry, Adv. Funct. Mater. 20 (2010) 579-586, https://doi.org/ 10.1002/adfm.200901400. · DOI
  43. D. Xu, J.L. Hawk, D.M. Loveless, S.L. Jeon, S.L. Craig, Mechanism of shear thickening in reversibly cross-linked supramolecular polymer networks, Macromolecules 43 (2010) 3556-3565, https://doi.org/10.1021/ma100093b. · DOI
  44. D. Xu, C.Y. Liu, S.L. Craig, Divergent shear thinning and shear thickening behavior of supramolecular polymer networks in semidilute entangled polymer solutions, Macromolecules 44 (2011) 2343-2353, https://doi.org/ 10.1021/ma2000916. · DOI
  45. S. Seiffert, J. Sprakel, Physical chemistry of supramolecular polymer networks, Chem. Soc. Rev. 41 (2012) 909-930, https://doi.org/10.1039/c1cs15191f. · DOI
  46. B. Marco-Dufort, R. Iten, M.W. Tibbitt, Linking molecular behavior to macroscopic properties in ideal dynamic covalent networks, J. Am. Chem. Soc. 142 (2020) 15371-15385, https://doi.org/10.1021/jacs.0c06192. · DOI
  47. C.B. Rodell, A.L. Kaminski, J.A. Burdick, Rational design of network properties in guest-host assembled and shear-thinning hyaluronic acid hydrogels, Biomacromolecules 14 (2013) 4125-4134, https://doi.org/10.1021/ bm401280z. · DOI
  48. L. Qin, P. Duan, F. Xie, L. Zhang, M. Liu, A metal ion triggered shrinkable supramolecular hydrogel and controlled release by an amphiphilic peptide dendron, Chem. Commun. 49 (2013) 10823-10825, https://doi.org/10.1039/ c3cc47004k. · DOI
  49. J. Li, D.J. Mooney, Designing hydrogels for controlled drug delivery, Nat. Rev. Mater. 1 (2016) 16071, https://doi.org/10.1038/natrevmats.2016.71. · DOI
  50. P.L. Ritger, N.A. Peppas, A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs, J. Control. Release 5 (1987) 23-36, https:// doi.org/10.1016/0168-3659(87)90034-4. · DOI
  51. B. Amsden, Solute diffusion within hydrogels, Mech. Models Macromol. 31 (1998) 8382-8395, https://doi.org/10.1021/ma980765f. · DOI
  52. E. Axpe, D. Chan, G.S. Offeddu, Y. Chang, D. Merida, H.L. Hernandez, E.A. Appel, A multiscale model for solute diffusion in hydrogels, Macromolecules 52 (2019) 6889-6897, https://doi.org/10.1021/acs.macromol.9b00753. · DOI
  53. B. Marco-Dufort, J. Willi, F. Vielba-Gomez, F. Gatti, M.W. Tibbitt, Environment controls biomolecule release from dynamic covalent hydrogels, Biomacromolecules 22 (2021) 146-157, https://doi.org/10.1021/acs. biomac.0c00895. · DOI
  54. E.A. Appel, R.A. Forster, M.J. Rowland, O.A. Scherman, The control of cargo release from physically crosslinked hydrogels by crosslink dynamics, Biomaterials 35 (2014) 9897-9903, https://doi.org/10.1016/j. biomaterials.2014.08.001. · DOI
  55. P.Y.W. Dankers, T.M. Hermans, T.W. Baughman, Y. Kamikawa, R.E. Kieltyka, M.M.C. Bastings, H.M. Janssen, N.A.J.M. Sommerdijk, A. Larsen, M.J.A. Van Luyn, A.W. Bosman, E.R. Popa, G. Fytas, E.W. Meijer, Hierarchical formation of supramolecular transient networks in water: a modular injectable delivery system, Adv. Mater. 24 (2012) 2703-2709, https://doi.org/10.1002/ adma.201104072. · DOI
  56. M.A. Rahim, M. Björnmalm, T. Suma, M. Faria, Y. Ju, K. Kempe, M. Müllner, H. Ejima, A.D. Stickland, F. Caruso, Metal-phenolic supramolecular gelation, Angew. Chemie -Int. Ed. 55 (2016) 13803-13807, https://doi.org/10.1002/ anie.201608413. · DOI
  57. R.M. Nalbandian, R.L. Henry, H.S. Wilks, Artifical skin. II. Pluronic F-127 silver nitrate or silver lactate gel in the treatment of thermal burns, J. Biomed. Mater. Res. 6 (1972) 583-590, https://doi.org/10.1002/ jbm.820060610. · DOI
  58. L. Zhang, L. Wang, B. Guo, P.X. Ma, Cytocompatible injectable carboxymethyl chitosan/N-isopropylacrylamide hydrogels for localized drug delivery, Carbohydr. Polym. 103 (2014) 110-118, https://doi.org/10.1016/ j.carbpol.2013.12.017. · DOI
  59. Y.S. Jung, W. Park, H. Park, D.K. Lee, K. Na, Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127 for sustained NSAID delivery, Carbohydr. Polym. 156 (2017) 403-408, https:// doi.org/10.1016/j.carbpol.2016.08.068. · DOI
  60. G. Zhang, Y. Chen, Y. Deng, T. Ngai, C. Wang, Dynamic supramolecular hydrogels: regulating hydrogel properties through self-complementary quadruple hydrogen bonds and thermo-switch, ACS Macro Lett. 6 (2017) 641-646, https://doi.org/10.1021/acsmacrolett.7b00275. · DOI
  61. J. Li, X. Li, X. Ni, X. Wang, H. Li, K.W. Leong, Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and a-cyclodextrin for controlled drug delivery, Biomaterials 27 (2006) 4132- 4140, https://doi.org/10.1016/j.biomaterials.2006.03.025. · DOI
  62. H. Dong, W. Hua, S. Li, Estimation on the individual hydrogen-bond strength in molecules with multiple hydrogen bonds, J. Phys. Chem. A 111 (2007) 2941-2945, https://doi.org/10.1021/jp0709860. · DOI
  63. S.K. Yang, S.C. Zimmerman, Hydrogen bonding modules for use in supramolecular polymers, Isr. J. Chem. 53 (2013) 511-520, https://doi.org/ 10.1002/ijch.201300045. · DOI
  64. B.J.B. Folmer, R.P. Sijbesma, R.M. Versteegen, J.A.J. Van Der Rijt, E.W. Meijer, Supramolecular polymer materials: chain extension of telechelic polymers using a reactive hydrogen-bonding synthon, Adv. Mater. 12 (2000) 874-878, https://doi.org/10.1002/1521-4095(200006)12:12<874::AID-ADMA874>3.0. CO;2-C. · DOI
  65. J.H.K.K. Hirschberg, L. Brunsveid, A. Ramzi, J.A.J.M. Vekemans, R.P. Sijbesma, E. W. Meijer, Helical self-assembled polymers from cooperative stacking of hydrogen-bonded pairs, Nature 407 (2000) 167-170, https://doi.org/10.1038/ 35025027. · DOI
  66. Y.J. Wang, X.N. Zhang, Y. Song, Y. Zhao, L. Chen, F. Su, L. Li, Z.L. Wu, Q. Zheng, Ultrastiff and tough supramolecular hydrogels with a dense and robust hydrogen bond network, Chem. Mater. 31 (2019) 1430-1440, https://doi.org/ 10.1021/acs.chemmater.8b05262. · DOI
  67. T. Liu, C. Jiao, X. Peng, Y.N. Chen, Y. Chen, C. He, R. Liu, H. Wang, Super-strong and tough poly(vinyl alcohol)/poly(acrylic acid) hydrogels reinforced by hydrogen bonding, J. Mater. Chem. B 6 (2018) 8105-8114, https://doi.org/ 10.1039/c8tb02556h. · DOI
  68. M. Guo, L.M. Pitet, H.M. Wyss, M. Vos, P.Y.W. Dankers, E.W. Meijer, Tough stimuli-responsive supramolecular hydrogels with hydrogen-bonding network junctions, J. Am. Chem. Soc. 136 (2014) 6969-6977, https://doi. org/10.1021/ja500205v. · DOI · Paper page
  69. F. Mo, K. Jiang, D. Zhao, Y. Wang, J. Song, W. Tan, DNA hydrogel-based gene editing and drug delivery systems, Adv. Drug Deliv. Rev. 168 (2021) 79-98, https://doi.org/10.1016/j.addr.2020.07.018. · DOI
  70. S.C. Grindy, R. Learsch, D. Mozhdehi, J. Cheng, D.G. Barrett, Z. Guan, P.B. Messersmith, N. Holten-Andersen, Control of hierarchical polymer mechanics with bioinspired metal-coordination dynamics, Nat. Mater. 14 (2015) 1210- 1216, https://doi.org/10.1038/nmat4401. · DOI
  71. N. Holten-Andersen, M.J. Harrington, H. Birkedal, B.P. Lee, P.B. Messersmith, K.Y.C. Lee, J.H. Waite, pH-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli, Proc. Natl. Acad. Sci. U. S. A. 108 (2011) 2651-2655, https://doi.org/10.1073/ pnas.1015862108. · DOI · Paper page
  72. T.N. Pham, C.F. Su, C.C. Huang, J.S. Jan, Biomimetic hydrogels based on L-Dopa conjugated gelatin as pH-responsive drug carriers and antimicrobial agents, Colloids Surfaces B Biointerf. 196 (2020) 111316, https://doi.org/10.1016/ j.colsurfb.2020.111316. · DOI
  73. X. Xu, V.V. Jerca, R. Hoogenboom, Self-healing metallo-supramolecular hydrogel based on specific Ni 2+ coordination interactions of poly(ethylene glycol) with bistriazole pyridine ligands in the main chain, Macromol. Rapid Commun. 41 (2020) 1900457, https://doi.org/10.1002/marc.201900457. · DOI
  74. L. Shi, H. Carstensen, K. Hölzl, M. Lunzer, H. Li, J. Hilborn, A. Ovsianikov, D.A. Ossipov, Dynamic coordination chemistry enables free directional printing of biopolymer hydrogel, Chem. Mater. 29 (2017) 5816-5823, https://doi.org/ 10.1021/acs.chemmater.7b00128. · DOI
  75. P.M. Lopez-Perez, R.M.P. Da Silva, I. Strehin, P.H.J. Kouwer, S.C.G. Leeuwenburgh, P.B. Messersmith, Self-healing hydrogels formed by complexation between calcium ions and bisphosphonate-functionalized star-shaped polymers, Macromolecules 50 (2017) 8698-8706, https://doi. org/10.1021/acs.macromol.7b01417. · DOI
  76. Q. Tang, D. Zhao, Q. Zhou, H. Yang, K. Peng, X. Zhang, Polyhistidine-based metal coordination hydrogels with physiologically relevant pH responsiveness and enhanced stability through a novel synthesis, Macromol. Rapid Commun. 39 (2018) 1800109, https://doi.org/ 10.1002/marc.201800109. · DOI
  77. Q. Tang, D. Zhao, H. Yang, L. Wang, X. Zhang, A pH-responsive self-healing hydrogel based on multivalent coordination of Ni 2+ with polyhistidine- terminated PEG and IDA-modified oligochitosan, J. Mater. Chem. B 7 (2019) 30-42, https://doi.org/10.1039/c8tb02360c. · DOI
  78. M. Björnmalm, L.M. Wong, J.P. Wojciechowski, J. Penders, C.C. Horgan, M.A. Booth, N.G. Martin, S. Sattler, M.M. Stevens, In vivo biocompatibility and immunogenicity of metal-phenolic gelation, Chem. Sci. 10 (2019) 10179- 10194, https://doi.org/10.1039/C9SC03325D. · DOI
  79. G. Zhang, L. Lv, Y. Deng, C. Wang, Self-healing gelatin hydrogels cross-linked by combining multiple hydrogen bonding and ionic coordination, Macromol. Rapid Commun. 38 (2017) 1700018, https://doi.org/ 10.1002/marc.201700018. · DOI
  80. S.M. Biros, J. Rebek, Structure and binding properties of water-soluble cavitands and capsules, Chem. Soc. Rev. 36 (2007) 93-104, https://doi.org/ 10.1039/b508530f. · DOI
  81. C.B. Rodell, J.E. Mealy, J.A. Burdick, Supramolecular guest-host interactions for the preparation of biomedical materials, Bioconjug. Chem. 26 (2015) 2279- 2289, https://doi.org/10.1021/acs.bioconjchem.5b00483. · DOI
  82. J. Lagona, P. Mukhopadhyay, S. Chakrabarti, L. Isaacs, The cucurbit[n]uril family, Angew. Chemie -Int. Ed. 44 (2005) 4844-4870, https://doi.org/ 10.1002/anie.200460675. · DOI
  83. E.A. Appel, J. del Barrio, X.J. Loh, O.A. Scherman, Supramolecular polymeric hydrogels, Chem. Soc. Rev. 41 (2012) 6195-6214, https://doi.org/10.1039/ c2cs35264h. · DOI
  84. S.D. Eastburn, B.Y. Tao, Applications of modified cyclodextrins, Biotechnol. Adv. 12 (1994) 325-339, https://doi.org/10.1016/0734-9750(94)90015-9. · DOI
  85. T. Loftsson, D. Duchêne, Cyclodextrins and their pharmaceutical applications, Int. J. Pharm. 329 (2007) 1-11, https://doi.org/10.1016/j. ijpharm.2006.10.044. · DOI
  86. E.M.M. Del Valle, Cyclodextrins and their uses: a review, Process Biochem. 39 (2004) 1033-1046, https://doi.org/10.1016/S0032-9592(03)00258-9. · DOI · Paper page
  87. M.V. Rekharsky, Y. Inoue, Complexation thermodynamics of cyclodextrins, Chem. Rev. 98 (1998) 1875-1917, https://doi.org/10.1021/cr970015o. · DOI
  88. A. Harada, J. Li, M. Kamachi, Double-stranded inclusion complexes of cyclodextrin threaded on poly(ethylene glycol), Nature 370 (1994) 126- 128, https://doi.org/10.1038/370126a0. · DOI
  89. A. Harada, J. Li, M. Kamachi, The molecular necklace: a rotaxane containing many threaded a-cyclodextrins, Nature 356 (1992) 325-327, https://doi.org/ 10.1038/356325a0. · DOI
  90. M. Nakahata, Y. Takashima, H. Yamaguchi, A. Harada, Redox-responsive self- healing materials formed from host-guest polymers, Nat. Commun. 2 (2011) 1-6, https://doi.org/10.1038/ncomms1521. · DOI
  91. A.M. Rosales, C.B. Rodell, M.H. Chen, M.G. Morrow, K.S. Anseth, J.A. Burdick, Reversible control of network properties in azobenzene-containing hyaluronic acid-based hydrogels, Bioconjug. Chem. 29 (2018) 905-913, https://doi.org/10.1021/acs.bioconjchem.7b00802. · DOI
  92. M. Wang, X. Zhang, L. Li, J. Wang, J. Wang, J. Ma, Z. Yuan, S.F. Lincoln, X. Guo, Photo-reversible supramolecular hydrogels assembled by a-cyclodextrin and azobenzene substituted poly(acrylic acid)s: effect of substitution degree, concentration, and tethered chain length, Macromol. Mater. Eng. 301 (2016) 191-198, https://doi.org/10.1002/mame.201500295. · DOI
  93. Y.G. Jia, X.X. Zhu, Self-healing supramolecular hydrogel made of polymers bearing cholic acid and b-cyclodextrin pendants, Chem. Mater. 27 (2015) 387-393, https://doi.org/10.1021/cm5041584. · DOI
  94. C. Loebel, C.B. Rodell, M.H. Chen, J.A. Burdick, Shear-thinning and self-healing hydrogels as injectable therapeutics and for 3D-printing, Nat. Protoc. 12 (2017) 1521-1541, https://doi.org/10.1038/nprot.2017.053. · DOI
  95. J.E. Mealy, C.B. Rodell, J.A. Burdick, Sustained small molecule delivery from injectable hyaluronic acid hydrogels through host-guest mediated retention, J. Mater. Chem. B 3 (2015) 8010-8019, https://doi.org/10.1039/c5tb00981b. · DOI
  96. C.B. Rodell, R.J. Wade, B.P. Purcell, N.N. Dusaj, J.A. Burdick, Selective proteolytic degradation of guest-host assembled, injectable hyaluronic acid hydrogels, ACS Biomater. Sci. Eng. 1 (2015) 277-286, https://doi.org/10.1021/ ab5001673. · DOI
  97. L.L. Wang, Y. Liu, J.J. Chung, T. Wang, A.C. Gaffey, M. Lu, C.A. Cavanaugh, S. Zhou, R. Kanade, P. Atluri, E.E. Morrisey, J.A. Burdick, Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury, Nat. Biomed. Eng. 1 (2017) 983-992, https://doi.org/10.1038/s41551-017-0157-y. · DOI · Paper page
  98. A.C. Gaffey, M.H. Chen, C.M. Venkataraman, A. Trubelja, C.B. Rodell, P.V. Dinh, G. Hung, J.W. Macarthur, R.V. Soopan, J.A. Burdick, P. Atluri, Injectable shear- thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium, J. Thorac. Cardiovasc. Surg. 150 (2015) 1268-1277, https://doi.org/10.1016/j.jtcvs.2015.07.035. · DOI
  99. L.L. Wang, J.N. Sloand, A.C. Gaffey, C.M. Venkataraman, Z. Wang, A. Trubelja, D.A. Hammer, P. Atluri, J.A. Burdick, Injectable, guest-host assembled polyethylenimine hydrogel for siRNA delivery, Biomacromolecules 18 (2017) 77-86, https://doi.org/10.1021/acs.biomac.6b01378. · DOI
  100. H. Aramoto, M. Osaki, S. Konishi, C. Ueda, Y. Kobayashi, Y. Takashima, A. Harada, H. Yamaguchi, Redox-responsive supramolecular polymeric networks having double-threaded inclusion complexes, Chem. Sci. 11 (2020) 4322-4331, https://doi.org/10.1039/c9sc05589d. · DOI
  101. H.J. Lee, P.T. Le, H.J. Kwon, K.D. Park, Supramolecular assembly of tetronic- adamantane and poly(b-cyclodextrin) as injectable shear-thinning hydrogels, J. Mater. Chem. B 7 (2019) 3374-3382, https://doi.org/10.1039/c9tb00072k. · DOI
  102. W. Zhao, Y. Li, X. Zhang, R. Zhang, Y. Hu, C. Boyer, F.J. Xu, Photo-responsive supramolecular hyaluronic acid hydrogels for accelerated wound healing, J. Control. Release 323 (2020) 24-35, https://doi.org/10.1016/j. jconrel.2020.04.014. · DOI
  103. G.A. Mandl, P.A. Rojas-Gutierrez, J.A. Capobianco, A NIR-responsive azobenzene-based supramolecular hydrogel using upconverting nanoparticles, Chem. Commun. 54 (2018) 5847-5850, https://doi.org/ 10.1039/c8cc03101k. · DOI
  104. B. Zhang, J. He, M. Shi, Y. Liang, B. Guo, Injectable self-healing supramolecular hydrogels with conductivity and photo-thermal antibacterial activity to enhance complete skin regeneration, Chem. Eng. J. 400 (2020) 125994, https://doi.org/10.1016/j.cej.2020.125994. · DOI
  105. J. Li, A. Harada, M. Kamachi, Sol-Gel transition during inclusion complex formation between a-cyclodextrin and high molecular weight poly(ethylene glycol)s in aqueous solution, Polym. J. 26 (1994) 1019-1026, https://doi.org/ 10.1295/polymj.26.1019. · DOI
  106. Z. Liu, P. Yao, Versatile injectable supramolecular hydrogels containing drug loaded micelles for delivery of various drugs, Polym. Chem. 5 (2014) 1072- 1081, https://doi.org/10.1039/c3py01083j. · DOI
  107. Z. Zhang, Z. He, R. Liang, Y. Ma, W. Huang, R. Jiang, S. Shi, H. Chen, X. Li, Fabrication of a micellar supramolecular hydrogel for ocular drug delivery, Biomacromolecules 17 (2016) 798-807, https://doi.org/10.1021/acs. biomac.5b01526. · DOI
  108. Q. Lin, Y. Yang, Q. Hu, Z. Guo, T. Liu, J. Xu, J. Wu, T.B. Kirk, D. Ma, W. Xue, Injectable supramolecular hydrogel formed from a-cyclodextrin and PEGylated arginine-functionalized poly(L-lysine) dendron for sustained MMP-9 shRNA plasmid delivery, Acta Biomater. 49 (2017) 456-471, https://doi.org/10.1016/j.actbio.2016.11.062. · DOI
  109. X. Song, Z. Zhang, J. Zhu, Y. Wen, F. Zhao, L. Lei, N. Phan-Thien, B.C. Khoo, J. Li, Thermoresponsive hydrogel induced by dual supramolecular assemblies and its controlled release property for enhanced anticancer drug delivery, Biomacromolecules 21 (2020) 1516-1527, https://doi.org/10.1021/acs. biomac.0c00077. · DOI
  110. W.A. Freeman, W.L. Mock, N.Y. Shih, Cucurbituril, J. Am. Chem. Soc. 103 (1981) 7367-7368, https://doi.org/10.1021/ja00414a070. · DOI
  111. K.I. Assaf, W.M. Nau, Cucurbiturils: from synthesis to high-affinity binding and catalysis, Chem. Soc. Rev. 44 (2015) 394-418, https://doi.org/10.1039/ c4cs00273c. · DOI
  112. E.A. Appel, X.J. Loh, S.T. Jones, C.A. Dreiss, O.A. Scherman, Sustained release of proteins from high water content supramolecular polymer hydrogels, Biomaterials 33 (2012) 4646-4652, https://doi.org/10.1016/j. biomaterials.2012.02.030. · DOI
  113. A. Tabet, R.A. Forster, C.C. Parkins, G. Wu, O.A. Scherman, Modulating stiffness with photo-switchable supramolecular hydrogels, Polym. Chem. 10 (2019) 467-472, https://doi.org/10.1039/c8py01554f. · DOI
  114. L. Zou, A.S. Braegelman, M.J. Webber, Dynamic supramolecular hydrogels spanning an unprecedented range of hostÀguest affinity, ACS Appl. Mater. Interf. 11 (2019) 5700, https://doi.org/10.1021/acsami.8b22151. · DOI
  115. A.K. Gaharwar, N.A. Peppas, A. Khademhosseini, Nanocomposite hydrogels for biomedical applications, Biotechnol. Bioeng. 111 (2014) 441-453, https:// doi.org/10.1002/bit.25160. · DOI
  116. S. Bernhard, G. Bovone, E.A. Guzzi, M.W. Tibbitt, Polymer-nanoparticle hydrogels, Chimia (Aarau). 73 (2019) 1034, https://doi.org/10.2533/ chimia.2019.1034. · DOI
  117. E. Alarçin, T.Y. Lee, S. Karuthedom, M. Mohammadi, M.A. Brennan, D.H. Lee, A. Marrella, J. Zhang, D. Syla, Y.S. Zhang, A. Khademhosseini, H.L. Jang, Injectable shear-thinning hydrogels for delivering osteogenic and angiogenic cells and growth factors, Biomater. Sci. 6 (2018) 1604-1615, https://doi.org/10.1039/ c8bm00293b. · DOI
  118. E.A. Appel, M.W. Tibbitt, M.J. Webber, B.A. Mattix, O. Veiseh, R. Langer, Self- assembled hydrogels utilizing polymer-nanoparticle interactions, Nat. Commun. 6 (2015) 6295, https://doi.org/10.1038/ncomms7295. · DOI
  119. A. Nelson, T. Cosgrove, Dynamic light scattering studies of poly(ethylene oxide) adsorbed on laponite: layer conformation and its effect on particle stability, Langmuir 20 (2004) 10382-10388, https://doi.org/10.1021/ la049323p. · DOI
  120. C. Li, C. Mu, W. Lin, T. Ngai, Gelatin effects on the physicochemical and hemocompatible properties of gelatin/PAAm/laponite nanocomposite hydrogels, ACS Appl. Mater. Interfaces 7 (2015) 18732-18741, https://doi. org/10.1021/acsami.5b05287. · DOI
  121. A.K. Gaharwar, R.K. Avery, A. Assmann, A. Paul, G.H. McKinley, A. Khademhosseini, B.D. Olsen, Shear-thinning nanocomposite hydrogels for the treatment of hemorrhage, ACS Nano 8 (2014) 9833-9842, https://doi.org/ 10.1021/nn503719n. · DOI
  122. A.K. Gaharwar, S.M. Mihaila, A. Swami, A. Patel, S. Sant, R.L. Reis, A.P. Marques, M.E. Gomes, A. Khademhosseini, Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells, Adv. Mater. 25 (2013) 3329-3336, https://doi.org/10.1002/adma.201300584. · DOI
  123. B.O. Okesola, S. Ni, B. Derkus, C.C. Galeano, A. Hasan, Y. Wu, J. Ramis, L. Buttery, J.I. Dawson, M. D'Este, R.O.C. Oreffo, D. Eglin, H. Sun, A. Mata, Growth-factor free multicomponent nanocomposite hydrogels that stimulate bone formation, Adv. Funct. Mater. 30 (2020) 1906205, https://doi.org/ 10.1002/adfm.201906205. · DOI
  124. A.K. Gaharwar, V. Kishore, C. Rivera, W. Bullock, C.J. Wu, O. Akkus, G. Schmidt, Physically crosslinked nanocomposites from silicate-crosslinked PEO: mechanical properties and osteogenic differentiation of human mesenchymal stem cells, Macromol. Biosci. 12 (2012) 779-793, https://doi. org/10.1002/mabi.201100508. · DOI
  125. A. Sheikhi, S. Afewerki, R. Oklu, A.K. Gaharwar, A. Khademhosseini, Effect of ionic strength on shear-thinning nanoclay-polymer composite hydrogels, Biomater. Sci. 6 (2018) 2073-2083, https://doi.org/10.1039/c8bm00469b. · DOI
  126. A.C. Yu, A.A.A. Smith, E.A. Appel, Structural considerations for physical hydrogels based on polymer-nanoparticle interactions, Mol. Syst. Des. Eng. 5 (2020) 401-407, https://doi.org/10.1039/C9ME00120D. · DOI
  127. E.A. Guzzi, G. Bovone, M.W. Tibbitt, Universal nanocarrier ink platform for biomaterials additive manufacturing, Small 15 (2019) 1905421, https://doi. org/10.1002/smll.201905421. · DOI
  128. E.A. Appel, M.W. Tibbitt, J.M. Greer, O.S. Fenton, K. Kreuels, D.G. Anderson, R. Langer, Exploiting electrostatic interactions in polymer-nanoparticle hydrogels, ACS Macro Lett. 4 (2015) 848-852, https://doi.org/10.1021/ acsmacrolett.5b00416. · DOI
  129. G. Roth, E. Gale, M. Alcántara-Hernández, W. Luo, E. Axpe, R. Verma, Q. Yin, A. Yu, H.L. Hernandez, C. Maikawa, A. Smith, M. Davis, B. Pulendran, J. Idoyaga, E. Appel, Injectable hydrogels for sustained co-delivery of subunit vaccines enhance humoral immunity pp. 26.117465 BioRxiv. 2020 (05) (2020), https://doi.org/10.1101/2020.05.26.117465. · DOI
  130. A.N. Steele, M.J. Paulsen, H. Wang, L.M. Stapleton, H.J. Lucian, A. Eskandari, C. E. Hironaka, J.M. Farry, S.W. Baker, A.D. Thakore, K.J. Jaatinen, Y. Tada, M.J. Hollander, K.M. Williams, A.J. Seymour, K.P. Totherow, A.C. Yu, J.R. Cochran, E. A. Appel, Y.J. Woo, Multi-phase catheter-injectable hydrogel enables dual- stage protein-engineered cytokine release to mitigate adverse left ventricular remodeling following myocardial infarction in a small animal model and a large animal model, Cytokine 127 (2020) 154974, https://doi.org/10.1016/ j.cyto.2019.154974. · DOI
  131. O.S. Fenton, M.W. Tibbitt, E.A. Appel, S. Jhunjhunwala, M.J. Webber, R. Langer, Injectable polymer-nanoparticle hydrogels for local immune cell recruitment, Biomacromolecules 20 (2019) 4430-4436, https://doi.org/ 10.1021/acs.biomac.9b01129. · DOI
  132. G. Bovone, E.A. Guzzi, M.W. Tibbitt, Flow-based reactor design for the continuous production of polymeric nanoparticles, AIChE J. 65 (2019), https://doi.org/10.1002/aic.16840. · DOI
  133. G. Bovone, F. Steiner, E.A. Guzzi, M.W. Tibbitt, Automated and continuous production of polymeric nanoparticles, Front. Bioeng. Biotechnol. 7 (2019) 423, https://doi.org/10.3389/fbioe.2019.00423. · DOI
  134. A. Parisi-Amon, D.D. Lo, D.T. Montoro, R.E. Dewi, M.T. Longaker, S.C. Heilshorn, Protein-nanoparticle hydrogels that self-assemble in response to peptide-based molecular recognition, ACS Biomater. Sci. Eng. 3 (2017) 750- 756, https://doi.org/10.1021/acsbiomaterials.6b00286. · DOI
  135. L. Shi, Y. Han, J. Hilborn, D. Ossipov, ''Smart" drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium- biopolymer chemistry, Chem. Commun. 52 (2016) 11151-11154, https://doi. org/10.1039/c6cc05565f. · DOI
  136. Q. Wang, L. Wang, M.S. Detamore, C. Berkland, Biodegradable colloidal gels as moldable tissue engineering scaffolds, Adv. Mater. 20 (2008) 236-239, https://doi.org/10.1002/adma.200702099. · DOI
  137. Q. Wang, J. Wang, Q. Lu, M.S. Detamore, C. Berkland, Injectable PLGA based colloidal gels for zero-order dexamethasone release in cranial defects, Biomaterials 31 (2010) 4980-4986, https://doi.org/10.1016/j. biomaterials.2010.02.052. · DOI
  138. Z. Gu, A.A. Aimetti, Q. Wang, T.T. Dang, Y. Zhang, O. Veiseh, H. Cheng, R.S. Langer, D.G. Anderson, Injectable nano-network for glucose-mediated insulin delivery, ACS Nano 7 (2013) 4194-4201, https://doi.org/10.1021/nn400630x. · DOI
  139. N. Habibi, N. Kamaly, A. Memic, H. Shafiee, Self-assembled peptide-based nanostructures: smart nanomaterials toward targeted drug delivery, Nano Today 11 (2016) 41-60, https://doi.org/10.1016/j.nantod.2016.02.004. · DOI
  140. M. Abbas, R. Xing, N. Zhang, Q. Zou, X. Yan, Antitumor photodynamic therapy based on dipeptide fibrous hydrogels with incorporation of photosensitive drugs, ACS Biomater. Sci. Eng. 4 (2018) 2046-2052, https://doi.org/10.1021/ acsbiomaterials.7b00624. · DOI
  141. Y. Loo, S. Zhang, C.A.E. Hauser, From short peptides to nanofibers to macromolecular assemblies in biomedicine, Biotechnol. Adv. 30 (2012) 593-603, https://doi.org/10.1016/j.biotechadv.2011.10.004. · DOI
  142. P.K. Gavel, D. Dev, H.S. Parmar, S. Bhasin, A.K. Das, Investigations of peptide- based biocompatible injectable shape-memory hydrogels: differential biological effects on bacterial and human blood cells, ACS Appl. Mater. Interfaces 10 (2018) 10729-10740, https://doi.org/10.1021/acsami.8b00501. · DOI
  143. M. Tao, J. Liu, S. He, K. Xu, W. Zhong, In situ hydrogelation of forky peptides in prostate tissue for drug delivery, Soft Matter 15 (2019) 4200-4207, https:// doi.org/10.1039/c9sm00196d. · DOI
  144. B.F. Lin, K.A. Megley, N. Viswanathan, D.V. Krogstad, L.B. Drews, M.J. Kade, Y. Qian, M.V. Tirrell, PH-responsive branched peptide amphiphile hydrogel designed for applications in regenerative medicine with potential as injectable tissue scaffolds, J. Mater. Chem. 22 (2012) 19447-19454, https:// doi.org/10.1039/c2jm31745a. · DOI
  145. A. Mahler, M. Reches, M. Rechter, S. Cohen, E. Gazit, Rigid, self-assembled hydrogel composed of a modified aromatic dipeptide, Adv. Mater. 18 (2006) 1365-1370, https://doi.org/10.1002/adma.200501765. · DOI
  146. A. Aggeli, I.A. Nyrkova, M. Bell, R. Harding, L. Carrick, T.C.B. McLeish, A.N. Semenov, N. Boden, Hierarchical self-assembly of chiral rod-like molecules as a model for peptide b-sheet tapes, ribbons, fibrils, and fibers, Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 11857-11862, https://doi.org/10.1073/ pnas.191250198. · DOI
  147. C. Hu, X. Liu, W. Ran, J. Meng, Y. Zhai, P. Zhang, Q. Yin, H. Yu, Z. Zhang, Y. Li, Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer, Biomaterials 144 (2017) 60- 72, https://doi.org/10.1016/j.biomaterials.2017.08.009. · DOI
  148. C. Yan, A. Altunbas, T. Yucel, R.P. Nagarkar, J.P. Schneider, D.J. Pochan, Injectable solid hydrogel: mechanism of shear-thinning and immediate recovery of injectable b-hairpin peptide hydrogels, Soft Matter 6 (2010) 5143-5156, https://doi.org/10.1039/c0sm00642d. · DOI
  149. M.R. Caplan, E.M. Schwartzfarb, S. Zhang, R.D. Kamm, D.A. Lauffenburger, Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence, Biomaterials 23 (2002) 219-227, https:// doi.org/10.1016/S0142-9612(01)00099-0. · DOI
  150. M. Tao, K. Xu, S. He, H. Li, L. Zhang, X. Luo, W. Zhong, Zinc-ion-mediated self- assembly of forky peptides for prostate cancer-specific drug delivery, Chem. Commun. 54 (2018) 4673-4676, https://doi.org/10.1039/c8cc00604k. · DOI
  151. N.P. Zaksas, S.E. Soboleva, G.A. Nevinsky, Twenty element concentrations in human organs determined by two-jet plasma atomic emission spectrometry, Sci. World J. 2019 (2019), https://doi.org/10.1155/2019/9782635. · DOI
  152. G. Chen, J. Li, Y. Cai, J. Zhan, J. Gao, M. Song, Y. Shi, Z. Yang, A glycyrrhetinic acid-modified curcumin supramolecular hydrogel for liver tumor targeting therapy, Sci. Rep. 7 (2017) 1-8, https://doi.org/10.1038/srep44210. · DOI
  153. E. Radvar, H.S. Azevedo, Supramolecular peptide/polymer hybrid hydrogels for biomedical applications, Macromol. Biosci. 19 (2019) 1800221, https:// doi.org/10.1002/mabi.201800221. · DOI
  154. C.M. Rubert Pérez, A. Panitch, J. Chmielewski, A collagen peptide-based physical hydrogel for cell encapsulation, Macromol. Biosci. 11 (2011) 1426- 1431, https://doi.org/10.1002/mabi.201100230. · DOI
  155. C. Tondera, R. Wieduwild, E. Röder, C. Werner, Y. Zhang, J. Pietzsch, In vivo examination of an injectable hydrogel system crosslinked by peptide- oligosaccharide interaction in immunocompetent nude mice, Adv. Funct. Mater. 27 (2017) 1605189, https://doi.org/10.1002/adfm.201605189. · DOI
  156. H.D. Lu, M.B. Charati, I.L. Kim, J.A. Burdick, Injectable shear-thinning hydrogels engineered with a self-assembling Dock-and-Lock mechanism, Biomaterials 33 (2012) 2145-2153, https://doi.org/10.1016/j. biomaterials.2011.11.076. · DOI
  157. M. Cao, Y. Wang, X. Hu, H. Gong, R. Li, H. Cox, J. Zhang, T.A. Waigh, H. Xu, J.R. Lu, Reversible thermoresponsive peptide-PNIPAM hydrogels for controlled drug delivery, Biomacromolecules 20 (2019) 3601-3610, https://doi.org/ 10.1021/acs.biomac.9b01009. · DOI
  158. E. Radvar, H.S. Azevedo, Supramolecular nanofibrous peptide/polymer hydrogels for the multiplexing of bioactive signals, ACS Biomater. Sci. Eng. 5 (2019) 4646-4656, https://doi.org/10.1021/acsbiomaterials.9b00941. · DOI
  159. M.C. Branco, D.J. Pochan, N.J. Wagner, J.P. Schneider, The effect of protein structure on their controlled release from an injectable peptide hydrogel, Biomaterials 31 (2010) 9527-9534, https://doi.org/10.1016/j. biomaterials.2010.08.047. · DOI
  160. W. Wu, Z. Zhang, T. Xiong, W. Zhao, R. Jiang, H. Chen, X. Li, Calcium ion coordinated dexamethasone supramolecular hydrogel as therapeutic alternative for control of non-infectious uveitis, Acta Biomater. 61 (2017) 157-168, https://doi.org/10.1016/j.actbio.2017.05.024. · DOI
  161. B. Singh, A. Dhiman, A. Kumar Rajneesh, Slow release of ciprofloxacin from b- cyclodextrin containing drug delivery system through network formation and supramolecular interactions, Int. J. Biol. Macromol. 92 (2016) 390-400, https://doi.org/10.1016/j.ijbiomac.2016.07.060. · DOI
  162. L. Zou, A.S. Braegelman, M.J. Webber, Spatially defined drug targeting by in situ host-guest chemistry in a living animal, ACS Cent. Sci. 5 (2019) 1035- 1043, https://doi.org/10.1021/acscentsci.9b00195. · DOI
  163. L. Yang, C. Zhang, C. Ren, J. Liu, Y. Zhang, J. Wang, F. Huang, L. Zhang, J. Liu, Supramolecular hydrogel based on chlorambucil and peptide drug for cancer combination therapy, ACS Appl. Mater. Interfaces 11 (2019) 331-339, https:// doi.org/10.1021/acsami.8b18425. · DOI
  164. Q. Guo, Y. Liu, G. Mu, L. Yang, W. Wang, J. Liu, J. Liu, A peptide-drug hydrogel to enhance the anti-cancer activity of chlorambucil, Biomater. Sci. 8 (2020) 5638-5646, https://doi.org/10.1039/d0bm01001d. · DOI
  165. Q. Qian, D. Wang, L. Shi, Z. Zhang, J. Qian, J. Shen, C. Yu, X. Zhu, A pure molecular drug hydrogel for post-surgical cancer treatment, Biomaterials 265 (2021) 120403, https://doi.org/10.1016/j.biomaterials.2020.120403. · DOI
  166. M. Liu, X. Song, Y. Wen, J.L. Zhu, J. Li, Injectable thermoresponsive hydrogel formed by alginate-g-poly(N-isopropylacrylamide) that releases doxorubicin-encapsulated micelles as a smart drug delivery system, ACS Appl. Mater. Interfaces 9 (2017) 35673-35682, https://doi.org/10.1021/ acsami.7b12849. · DOI
  167. M. Zhang, J. Wang, Z. Jin, Supramolecular hydrogel formation between chitosan and hydroxypropyl b-cyclodextrin via Diels-Alder reaction and its drug delivery, Int. J. Biol. Macromol. 114 (2018) 381-391, https://doi.org/ 10.1016/j.ijbiomac.2018.03.106. · DOI
  168. T.T. Hoang Thi, Y. Lee, S.B. Ryu, H.J. Sung, K.D. Park, Oxidized cyclodextrin- functionalized injectable gelatin hydrogels as a new platform for tissue- adhesive hydrophobic drug delivery, RSC Adv. 7 (2017) 34053-34062, https://doi.org/10.1039/c7ra04137c. · DOI
  169. G. Tae, M. Scatena, P.S. Stayton, A.S. Hoffman, PEG-cross-linked heparin is an affinity hydrogel for sustained release of vascular endothelial growth factor, J. Biomater. Sci. Polym. Ed. 17 (2006) 187-197, https://doi.org/10.1163/ 156856206774879090. · DOI
  170. D. Ma, H. Bin Zhang, K. Tu, L.M. Zhang, Novel supramolecular hydrogel/ micelle composite for co-delivery of anticancer drug and growth factor, Soft Matter 8 (2012) 3665-3672, https://doi.org/10.1039/c2sm25060h. · DOI
  171. F. Zhang, C. Hu, Q. Kong, R. Luo, Y. Wang, Peptide-/drug-directed self- assembly of hybrid polyurethane hydrogels for wound healing, ACS Appl. Mater. Interfaces 11 (2019) 37147-37155, https://doi.org/10.1021/ acsami.9b13708. · DOI
  172. M.H. Bakker, E. van Rooij, P.Y.W. Dankers, Controlled release of RNAi molecules by tunable supramolecular hydrogel carriers, Chem. -An Asian J. 13 (2018) 3501-3508, https://doi.org/10.1002/asia.201800582. · DOI
  173. M. Zhu, K. Wei, S. Lin, X. Chen, C.-C. Wu, G. Li, L. Bian, Bioadhesive polymersome for localized and sustained drug delivery at pathological sites with harsh enzymatic and fluidic environment via supramolecular host-guest complexation, Small 14 (2018) 1702288, https://doi.org/10.1002/ smll.201702288. · DOI
  174. M.J. Webber, E.A. Appel, B. Vinciguerra, A.B. Cortinas, L.S. Thapa, S. Jhunjhunwala, L. Isaacs, R. Langer, D.G. Anderson, Supramolecular PEGylation of biopharmaceuticals, Proc. Natl. Acad. Sci. U. S. A. 113 (2016) 14189-14194, https://doi.org/10.1073/pnas.1616639113. · DOI
  175. C.L. Maikawa, A.A.A. Smith, L. Zou, C.M. Meis, J.L. Mann, M.J. Webber, E.A. Appel, Stable monomeric insulin formulations enabled by supramolecular PEGylation of insulin analogues, Adv. Ther. 3 (2020) 1900094, https://doi.org/ 10.1002/adtp.201900094. · DOI
  176. C.L. Maikawa, A.A.A. Smith, L. Zou, G.A. Roth, E.C. Gale, L.M. Stapleton, S.W. Baker, J.L. Mann, A.C. Yu, S. Correa, A.K. Grosskopf, C.S. Liong, C.M. Meis, D. Chan, M. Troxell, D.M. Maahs, B.A. Buckingham, M.J. Webber, E.A. Appel, A co- formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs, Nat. Biomed. Eng. 4 (2020) 507-517, https://doi.org/10.1038/s41551-020-0555-4. · DOI
  177. X. Li, J. Li, Y. Gao, Y. Kuang, J. Shi, B. Xu, Molecular nanofibers of olsalazine form supramolecular hydrogels for reductive release of an anti-inflammatory agent, J. Am. Chem. Soc. 132 (2010) 17707-17709, https://doi.org/ 10.1021/ja109269v. · DOI
  178. M.J. Webber, J.B. Matson, V.K. Tamboli, S.I. Stupp, Controlled release of dexamethasone from peptide nanofiber gels to modulate inflammatory response, Biomaterials 33 (2012) 6823-6832, https://doi.org/10.1016/j. biomaterials.2012.06.003. · DOI
  179. C. Li, H. Li, J. Guo, L. Li, X. Xi, Y. Yu, Biocompatible supramolecular pseudorotaxane hydrogels for controllable release of doxorubicin in ovarian cancer SKOV-3 cells, RSC Adv. 10 (2019) 689-697, https://doi.org/10.1039/ c9ra08986a. · DOI
  180. N. Nandi, K. Gayen, S. Ghosh, D. Bhunia, S. Kirkham, S.K. Sen, S. Ghosh, I.W. Hamley, A. Banerjee, Amphiphilic peptide-based supramolecular, noncytotoxic, stimuli-responsive hydrogels with antibacterial activity, Biomacromolecules 18 (2017) 3621-3629, https://doi.org/10.1021/acs. biomac.7b01006. · DOI
  181. D.A. Salick, D.J. Pochan, J.P. Schneider, Design of an injectable b-hairpin peptide hydrogel that kills methicillin-resistant Staphylococcus aureus, Adv. Mater. 21 (2009) 4120-4123, https://doi.org/10.1002/adma.200900189. · DOI
  182. C. Ren, Y. Gao, Y. Guan, Z. Wang, L. Yang, J. Gao, H. Fan, J. Liu, Carrier-free supramolecular hydrogel composed of dual drugs for conquering drug resistance, ACS Appl. Mater. Interf. 11 (2019) 33706-33715, https://doi.org/ 10.1021/acsami.9b12530. · DOI
  183. Q. Xue, H. Ren, C. Xu, G. Wang, C. Ren, J. Hao, D. Ding, Nanospheres of doxorubicin as cross-linkers for a supramolecular hydrogelation, Sci. Rep. 5 (2015) 1-6, https://doi.org/10.1038/srep08764. · DOI
  184. V.A. Kumar, S. Shi, B.K. Wang, I.C. Li, A.A. Jalan, B. Sarkar, N.C. Wickremasinghe, J.D. Hartgerink, Drug-triggered and cross-linked self- assembling nanofibrous hydrogels, J. Am. Chem. Soc. 137 (2015) 4823- 4830, https://doi.org/10.1021/jacs.5b01549. · DOI
  185. F. Wang, H. Su, D. Xu, W. Dai, W. Zhang, Z. Wang, C.F. Anderson, M. Zheng, R. Oh, F. Wan, H. Cui, Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel, Nat. Biomed. Eng. 4 (2020) 1090-1101, https://doi.org/10.1038/s41551-020- 0597-7. · DOI
  186. M. Naguib, Sugammadex: another milestone in clinical neuromuscular pharmacology, Anesth. Analg. 104 (2007) 575-581, https://doi.org/10.1213/ 01.ane.0000244594.63318.fc. · DOI
  187. M.E. Davis, The first targeted delivery of siRNA in humans via a self- assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic, Mol. Pharm. 6 (2009) 659-668, https://doi.org/10.1021/mp900015y. · DOI
  188. S. Gaur, L. Chen, T. Yen, Y. Wang, B. Zhou, M. Davis, Y. Yen, Preclinical study of the cyclodextrin-polymer conjugate of camptothecin CRLX101 for the treatment of gastric cancer, Nanomed. Nanotechnol. Biol. Med. 8 (2012) 721-730, https://doi.org/10.1016/j.nano.2011.09.007. · DOI
  189. L.A. Bockeria, O. Svanidze, A. Kim, K. Shatalov, V. Makarenko, M. Cox, T. Carrel, Total cavopulmonary connection with a new bioabsorbable vascular graft: first clinical experience, J. Thorac. Cardiovasc. Surg. 153 (2017) 1542-1550, https://doi.org/10.1016/j.jtcvs.2016.11.071. · DOI

Cited by

Sorted by citations

Authors
Bernhard, S., & Tibbitt, M. W.
Affiliations
ETH Zurich (CH)
Corresponding author
Tibbitt, Mark W.
ORCID
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2021-04
Volume
171
Pages
240-256
ISSN
0169-409X (ISSN-L)
DOI
10.1016/j.addr.2021.02.002
OpenAlex
W3127555104
Cited by
363
References
4
Citations by year
2026: 47 · 2025: 78 · 2024: 89 · 2023: 78 · 2022: 57 · 2021: 13 · 2012: 1
FWCI
4.36
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Drug Delivery Reviews (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
  • ETH Zürich Research Collection (cc-by)
Funders
  • Eidgenössische Technische Hochschule Zürich
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (200021_184697)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
  • Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
Keywords
supramolecular hydrogels, drug delivery systems, injectable hydrogel, sprayable hydrogel
MeSH terms
Animals, Humans, Drug Design, Drug Delivery Systems, Hydrogels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review