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The Structural Biology of Protein Aggregation Diseases: Fundamental Questions and Some Answers
Open accessAbstract
Amyloid fibrils are found in association with at least two dozen fatal diseases. The tendency of numerous proteins to convert into amyloid-like fibrils poses fundamental questions for structural biology and for protein science in general. Among these are the following: What is the structure of the cross-beta spine, common to amyloid-like fibrils? Is there a sequence signature for proteins that form amyloid-like fibrils? What is the nature of the structural conversion from native to amyloid states, and do fibril-forming proteins have two distinct stable states, the native state and the amyloid state? What is the basis of protein complementarity, in which a protein chain can bind to itself? We offer tentative answers here, based on our own recent structural studies.
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Cited by
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Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation
Gsponer, J., Futschik, M. E., Teichmann, S. A., & Babu, M. M. (2008) · Science · doi:10.1126/science.1163581 · Cited by 466
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Structural Characterization of a Soluble Amyloid β-Peptide Oligomer
Yu, L., Edalji, R., Harlan, J. E., Holzman, T. F., Lopez, A. P., Labkovsky, B., Hillen, H., Barghorn, S., Ebert, U., Richardson, P. L., et al. (2009) · Biochemistry · doi:10.1021/bi802046n · Cited by 354
Reinke, A. A., & Gestwicki, J. E. (2007) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2007.00557.x · Cited by 329
Non‐native protein aggregation kinetics
Roberts, C. J. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21627 · Cited by 329
Andrews, J. M., & Roberts, C. J. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp070212j · Cited by 250
Andronesi, O. C., Bergen, M. V., Biernat, J., Seidel, K., Griesinger, C., Mandelkow, E., & Baldus, M. (2008) · Journal of the American Chemical Society · doi:10.1021/ja7100517 · Cited by 167
Selectivity in ROS-Induced Peptide Backbone Bond Cleavage
Stringfellow, H. M., Jones, M. R., Green, M. C., Wilson, A. K., & Francisco, J. S. (2014) · The Journal of Physical Chemistry A · doi:10.1021/jp508877m · Cited by 28
Can Peptide Folding Simulations Provide Predictive Information for Aggregation Propensity?
Lin, E. I., & Shell, M. S. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp104114n · Cited by 12
Metadata
- Authors
- Eisenberg, D., Nelson, R., Sawaya, M. R., Balbirnie, M., Sambashivan, S., Ivanova, M. I., Madsen, A. Ø., & Riekel, C.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-09-01
- Volume
- 39
- Issue
- 9
- Pages
- 568-575
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2128547681
- Cited by
- 179
- References
- 0
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- green
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