Cited by 466Protein Structure and DynamicsRNA Research and SplicingUbiquitin and proteasome pathways

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

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Gsponer, Jörg, Futschik, Matthias E., Teichmann, Sarah A., Babu, M. Madan·2008·Science

Abstract

Altered abundance of several intrinsically unstructured proteins (IUPs) has been associated with perturbed cellular signaling that may lead to pathological conditions such as cancer. Therefore, it is important to understand how cells precisely regulate the availability of IUPs. We observed that regulation of transcript clearance, proteolytic degradation, and translational rate contribute to controlling the abundance of IUPs, some of which are present in low amounts and for short periods of time. Abundant phosphorylation and low stochasticity in transcription and translation indicate that the availability of IUPs can be finely tuned. Fidelity in signaling may require that most IUPs be available in appropriate amounts and not present longer than needed.

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  1. [1]Dunker AK J Mol Graph Model 2001 19 26 11381529
  2. [20]Mathes E O’Dea EL Hoffmann A Ghosh G Embo J 2008 27 1421 PMC2374849 18401342
  3. [21]O’Dea EL Mol Syst Biol 2007 3 111 17486138 PMC2673708

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Authors
Gsponer, J., Futschik, M. E., Teichmann, S. A., & Babu, M. M.
Affiliations
  • Medical Research Council (MRC) Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
  • MRC Laboratory of Molecular Biology (GB)
Corresponding author
Babu, M. Madan
Venue
Science
Published
2008-11-28
Volume
322
Issue
5906
Pages
1365-1368
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2154335467
Cited by
466
References
107
Citations by year
2026: 5 · 2025: 13 · 2024: 14 · 2023: 14 · 2022: 22 · 2021: 30 · 2020: 27 · 2019: 32 · 2018: 30 · 2017: 16 · 2016: 25 · 2015: 19 · 2014: 38 · 2013: 39 · 2012: 45
FWCI
13.29
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
intrinsically disordered proteins, protein abundance regulation, proteolysis, protein phosphorylation, transcriptional noise, cancer
MeSH terms
Amino Acid Sequence, Cell Cycle, Genes, Fungal, Humans, Phosphorylation, Protein Conformation, Protein Kinases, RNA, Fungal, RNA, Messenger, Saccharomyces cerevisiae, Transcription, Genetic, Protein Biosynthesis, Signal Transduction, Computational Biology, Proteome, Saccharomyces cerevisiae Proteins, Schizosaccharomyces pombe Proteins

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