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Cited by 321

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Bioresponsive, Cell-Penetrating, and Multimeric MR Contrast Agents

Open access
Major, Jody L., Meade, Thomas J.·2009·Accounts of Chemical Research
DOI 10.1021/ar800245h
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Abstract

Magnetic resonance imaging (MRI) has become increasingly popular in experimental molecular imaging and clinical radiology because it is non-invasive and capable of producing three-dimensional representations of opaque organisms with high spatial and temporal resolution. Approximately 35% of all clinical MR scans utilize contrast media, however a primary limitation of MR imaging is the sensitivity of contrast agents that require high concentrations (0.1-0.6 mM). A number of strategies have been employed to amplify the observed in vivo signal of MR contrast agents. Approaches include attachment of Gd(III) chelates to polymers, proteins and particles, encapsulation into micelles and caged structures, and targeting to receptors. While each of these approaches has yielded significant increases in the relaxivity of MR contrast agents (and therefore sensitivity), all of these classes of complexes possess intrinsic background signal and function solely as anatomical reporters. In order to reduce the background signal and simultaneously create probes that are modulated by biochemical processes, caged complexes were designed to coordinatively saturate the paramagnetic ion. Coupled with amplification strategies, these agents represent a means to selectively modulate the observed MR signal and function as in vivo biochemical reporters. For example, to create an in vivo MR assay of enzymatic activities and secondary messengers, agents have been designed and synthesized with removable protection groups that largely prevent access of water to a paramagnetic center. By limiting the access of bulk water (q-modulation) the unprocessed agent is designed to be an ineffective contrast agent, and hence serves as a reliable marker for regions of enzyme activity or the presence of secondary messengers. Further, we have focused on designing multimodal contrast agents that are simultaneously detectable by more than one imaging technique. For example, attaching an optical probe to a MR contrast agent provides the means to detect the probe in a whole animal and subsequently validate the results by histological methods. Finally, we describe strategies for signal amplification, and cell delivery vehicles attached to imaging probes for in vivo long-term fate mapping experiments.

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Metadata

Authors
Major, J. L., & Meade, T. J.
Venue
Accounts of Chemical Research
Publisher
American Chemical Society (ACS)
Published
2009-06-19
Volume
42
Issue
7
Pages
893-903
ISSN
  • 0001-4842 (ISSN-L)
  • 1520-4898
DOI
10.1021/ar800245h
OpenAlex
W1992834159
Cited by
321
References
39
FWCI
14.52
Type
journal article
Language
en
Open access
green

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