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Cited by 381

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

pH-Sensitive Cationic Polymer Gene Delivery Vehicle: N-Ac-poly(l-histidine)-graft-poly(l-lysine) Comb Shaped Polymer

Benns, Jonathan M., Choi, Joon-Sig, Mahato, Ram I., Park, Jong-Sang, Kim, Sung Wan·2000·Bioconjugate Chemistry
DOI 10.1021/bc0000177
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Abstract

Advancing biotechnology spurs the development of new pharmaceutically engineered gene delivery vehicles. Poly(L-histidine) ¿PLH¿ has been shown to induce membrane fusion at endosomal pH values, whereas PLL has a well documented efficacy in polyplex formation. Therefore, N-Ac-poly(L-histidine)-graft-poly(L-lysine) ¿PLH-g-PLL¿ was synthesized by grafting poly(L-histidine) to poly(L-lysine) ¿PLL¿. PLH-g-PLL formed polyplex particles by electrostatic interactions with plasmid DNA ¿pDNA¿. The mean particle size of the polyplexes was in the range of 117 +/- 6 nm to 306 +/- 77 nm. PLH-g-PLL gene carrier demonstrated higher transfection efficacy in 293T cells than PLL at all equivalent weight ratios with pDNA. The inclusion of chloroquine as an endosomolytic agent enhanced transfection for both PLL and PLH-g-PLL gene carriers. PLH-g-PLL enhanced beta-galactosidase expression compared to PLL, but still increased in efficacy when chloroquine was included.

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Crossref · 10.1021/bc0000177

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Metadata

Authors
Benns, J. M., Choi, J.-S., Mahato, R. I., Park, J.-S., & Kim, S. W.
Venue
Bioconjugate Chemistry
Publisher
American Chemical Society (ACS)
Published
2000-09-01
Volume
11
Issue
5
Pages
637-645
ISSN
  • 1043-1802 (ISSN-L)
  • 1520-4812
DOI
10.1021/bc0000177
OpenAlex
W1997664422
Cited by
381
References
37
FWCI
3.94
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.