The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Preparation of micelle-forming polymer-drug conjugates
Abstract
Adriamycin, a hydrophobic anticancer drug, was conjugated with poly(ethylene oxide)-poly(aspartic acid) block copolymers composed of various lengths of each block copolymer segment ranging from 1000 to 12,000 in molecular weight and from 10 to 80 units, respectively. Conjugation was achieved without precipitation by adjusting the ratio of adriamycin to aspartic acid residues of the block copolymer and the quantity of DMF used for the reaction. Thus obtained conjugates showed high water solubility irrespective of a large amount of the conjugated adriamycin. Furthermore, these conjugates were found to form micellar structures with a hydrophobic inner core and a hydrophilic outer shell. This micellar architecture may be utilized for effective drug targeting.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kabanov, A. V., Chekhonin, V. P., Alakhov, V. Y., Batrakova, E. V., Lebedev, A. S., Melik-Nubarov, N. S., Arzhakov, S. A., Levashov, A. V., Morozov, G. V., Severin, E. S., et al. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81689-8 · Cited by 296
Lundberg, R. D., & Doty, P. (1957) · Journal of the American Chemical Society · doi:10.1021/ja01572a004 · Cited by 202
Cited by
Polymeric micelles—A new generation of colloidal drug carriers
Jones, M.-C., & Leroux, J.-C. (1999) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00039-9 · Cited by 1,256
Owen, S. C., Chan, D. P. Y., & Shoichet, M. S. (2012) · Nano Today · doi:10.1016/j.nantod.2012.01.002 · Cited by 911
Advances in polymeric micelles for drug delivery and tumor targeting
Kedar, U., Phutane, P., Shidhaye, S., & Kadam, V. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2010.05.005 · Cited by 791
Folate receptor targeted biodegradable polymeric doxorubicin micelles
Yoo, H. S., & Park, T. G. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.02.003 · Cited by 620
Xu, W., Ling, P., & Zhang, T. (2013) · Journal of Drug Delivery · doi:10.1155/2013/340315 · Cited by 595
Polymeric Conjugates for Drug Delivery
Larson, N., & Ghandehari, H. (2012) · Chemistry of Materials · doi:10.1021/cm2031569 · Cited by 580
Li, H.-J., Du, J.-Z., Liu, J., Du, X.-J., Shen, S., Zhu, Y.-H., Wang, X., Ye, X., Nie, S., & Wang, J. (2016) · ACS Nano · doi:10.1021/acsnano.6b02326 · Cited by 537
Micelles and nanoparticles for ultrasonic drug and gene delivery
Husseini, G. A., & Pitt, W. G. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.008 · Cited by 468
Folate-targeted therapies for cancer
Xia, W., & Low, P. S. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100509v · Cited by 448
Kwon, G., Suwa, S., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90118-x · Cited by 409
Self-citationPrabaharan, M., Grailer, J. J., Pilla, S., Steeber, D. A., & Gong, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.020 · Cited by 377
Polymeric micelles: nanocarriers for cancer-targeted drug delivery
Zhang, Y., Huang, Y., & Li, S. (2014) · AAPS PharmSciTech · doi:10.1208/s12249-014-0113-z · Cited by 367
Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages
Yoo, H. S., Lee, E. A., & Park, T. G. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00088-3 · Cited by 324
Block copolymer micelles for drug delivery: loading and release of doxorubicin
Kwon, G., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00039-4 · Cited by 320
Self-citationYokoyama, M. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00115-6 · Cited by 308
Self-citationPhysical Entrapment of Adriamycin in AB Block Copolymer Micelles
Kwon, G. S., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1995) · Pharmaceutical Research · doi:10.1023/a:1016266523505 · Cited by 281
Self-citationpH-Dependent Micellization of Poly(2-vinylpyridine)-block-poly(ethylene oxide)
Martin, T. J., Procházka, K., Munk, P., & Webber, S. E. (1996) · Macromolecules · doi:10.1021/ma960629f · Cited by 259
Highly Efficient “Grafting onto” a Polypeptide Backbone Using Click Chemistry
Engler, A. C., Lee, H., & Hammond, P. T. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200904070 · Cited by 254
Dendrimeric micelles for controlled drug release and targeted delivery
Ambade, A. V., Savariar, E. N., & Thayumanavan, S. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050020d · Cited by 245
Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156
“DOX-loaded micelles, described as DDSs by Kataoka’s group in the early 1990s, have been utilized for the distribution of various anticancer agents in clinical and preclinical investigations [100].”
BackgroundOpanasopit, P., Yokoyama, M., Watanabe, M., Kawano, K., Maitani, Y., & Okano, T. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000048190.53439.eb · Cited by 141
Self-citationWatanabe, M., Kawano, K., Yokoyama, M., Opanasopit, P., Okano, T., & Maitani, Y. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.030 · Cited by 128
Self-citationUltrasonically triggered drug delivery: Breaking the barrier
Husseini, G. A., Pitt, W. G., & Martins, A. M. (2014) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2014.07.051 · Cited by 87
Amphiphilic block copolymers–based micelles for drug delivery
Imran, M., Shah, M. R., & Shafiullah (2018) · Design and Development of New Nanocarriers · doi:10.1016/b978-0-12-813627-0.00010-7 · Cited by 35
Metadata
- Authors
- Yokoyama, M., Kwon, G. S., Okano, T., Sakurai, Y., Seto, T., & Kataoka, K.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1992-07-01
- Volume
- 3
- Issue
- 4
- Pages
- 295-301
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W1999903282
- Cited by
- 294
- References
- 2
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
