The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Tat Peptide as an Efficient Molecule To Translocate Gold Nanoparticles into the Cell Nucleus
Abstract
The labeling of targeting molecules with nanoparticles has revolutionized the visualization of cellular or tissue components by electron microscopy. A particularly desirable target is the nucleus, because the genetic information is there. To date, utilizing nanoparticles for nuclear targeting has not proved very successful due to the impermeable nature of the plasma and nuclear membranes; thus nanoparticle design and synthesis is a critical factor. We report in this article the synthesis of water-soluble gold nanoparticles functionalized with a Tat protein-derived peptide sequence by a straightforward and economical methodology. The particles were subsequently tested in vitro with a human fibroblast cell line by optical and transmission electron microscopy to determine the biocompatibility of these nanoparticles and whether the functionalization with the translocation peptide allowed particles to transfer across the cell membrane and locate in the nucleus.
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Metadata
- Authors
- de la Fuente, J. M., & Berry, C. C.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-08-26
- Volume
- 16
- Issue
- 5
- Pages
- 1176-1180
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W1965665097
- Cited by
- 342
- References
- 11
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
