Peptide modified gold nanoparticles for improved cellular uptake, nuclear transport, and intracellular retention
Abstract
A novel hyperspectral imaging technique is used to image GNPs: a combination of three peptides is used for efficient nuclear targeting and improved retention of GNPs targeted into the nucleus is shown for the first time. This is important for future cancer therapeutics as GNPs can be used as radiation dose enhancers and anticancer drug carriers.
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Tripeptide modification of gold nanoparticles shows 5-fold NP uptake and effective nuclear localization.
“The modification of the tripeptide showed a 5-fold NP uptake and effective nuclear localization.236”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [236]
Cites
Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions
Frens, G. (1973) · Nature Physical Science · doi:10.1038/physci241020a0 · Cited by 8,373 · see citing works
Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells
Chithrani, D. B., Ghazani, A. A., & Chan, W. C. W. (2006) · Nano Letters · doi:10.1021/nl052396o · Cited by 4,887 · see citing works
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558 · see citing works
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233 · see citing works
The use of nanocrystals in biological detection
Alivisatos, A. P. (2003) · Nature Biotechnology · doi:10.1038/nbt927 · Cited by 3,006 · see citing works
The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles
Fröhlich, E. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s36111 · Cited by 2,496 · see citing works
Chithrani, D. B., & Chan, W. C. W. (2007) · Nano Letters · doi:10.1021/nl070363y · Cited by 2,274 · see citing works
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
Liong, M., Lu, J., Kovochich, M., Xia, T., Ruehm, S. G., Nel, A. E., Tamanoi, F., & Zink, J. I. (2008) · ACS Nano · doi:10.1021/nn800072t · Cited by 1,932 · see citing works
Shukla, R., Bansal, V., Chaudhary, M., Basu, A., Bhonde, R. R., & Sastry, M. (2005) · Langmuir · doi:10.1021/la0513712 · Cited by 1,689 · see citing works
Mediating Tumor Targeting Efficiency of Nanoparticles Through Design
Perrault, S. D., Walkey, C., Jennings, T. L., Fischer, H. C., & Chan, W. C. W. (2009) · Nano Letters · doi:10.1021/nl900031y · Cited by 1,516 · see citing works
Mechanics of receptor-mediated endocytosis
Gao, H., Shi, W., & Freund, L. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503879102 · Cited by 1,219 · see citing works
Size‐Dependent Endocytosis of Nanoparticles
Zhang, S., Li, J., Lykotrafitis, G., Bao, G., & Suresh, S. (2008) · Advanced Materials · doi:10.1002/adma.200801393 · Cited by 1,060 · see citing works
(1996) · Elsevier eBooks · doi:10.1016/b978-0-12-342335-1.x5000-3 · Cited by 1,016 · see citing works
Multifunctional Gold Nanoparticle−Peptide Complexes for Nuclear Targeting
Tkachenko, A. G., Xie, H., Coleman, D. M., Glomm, W. R., Ryan, J. A., Anderson, M. F., Franzen, S., & Feldheim, D. L. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0296935 · Cited by 795 · see citing works
Lee, J. E., Lee, N., Kim, H., Kim, J., Choi, S. H., Kim, J. H., Kim, T., Song, I. C., Park, S. P., Moon, W. K., et al. (2009) · Journal of the American Chemical Society · doi:10.1021/ja905793q · Cited by 706 · see citing works
Mechanisms of Receptor‐Mediated Nuclear Import and Nuclear Export
Pemberton, L. F., & Paschal, B. M. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00270.x · Cited by 689 · see citing works
The Nuclear Pore Complex and Nuclear TransportPreprint
Wente, S. R., & Rout, M. P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000562 · Cited by 688 · see citing works
Kang, B., Mackey, M. A., & El‐Sayed, M. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja9102698 · Cited by 681 · see citing works
Uptake and Intracellular Fate of Surface-Modified Gold Nanoparticles
Nativo, P., Prior, I. A., & Brust, M. (2008) · ACS Nano · doi:10.1021/nn800330a · Cited by 660 · see citing works
Emerging implications of nanotechnology on cancer diagnostics and therapeutics
Cuenca, A. G., Jiang, H., Hochwald, S. N., Delano, M. J., Cance, W. G., & Grobmyer, S. R. (2006) · Cancer · doi:10.1002/cncr.22035 · Cited by 473 · see citing works
Cellular Uptake of Elastic Nanoparticles
Yi, X., Shi, X., & Gao, H. (2011) · Physical Review Letters · doi:10.1103/physrevlett.107.098101 · Cited by 454 · see citing works
Tkachenko, A. G., Xie, H., Liu, Y., Coleman, D. M., Ryan, J. A., Glomm, W. R., Shipton, M. K., Franzen, S., & Feldheim, D. L. (2004) · Bioconjugate Chemistry · doi:10.1021/bc034189q · Cited by 449 · see citing works
Suntharalingam, M., & Wente, S. R. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00162-x · Cited by 410 · see citing works
Peptide-Conjugated Gold Nanorods for Nuclear Targeting
Oyelere, A. K., Chen, P. C., Huang, X., El‐Sayed, I. H., & El‐Sayed, M. A. (2007) · Bioconjugate Chemistry · doi:10.1021/bc070132i · Cited by 348 · see citing works
Tat Peptide as an Efficient Molecule To Translocate Gold Nanoparticles into the Cell Nucleus
de la Fuente, J. M., & Berry, C. C. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050033+ · Cited by 343 · see citing works
Wang, Z., Li, N., Zhao, J. L., White, J. C., Qu, P., & Xing, B. (2012) · Chemical Research in Toxicology · doi:10.1021/tx3002093 · Cited by 338 · see citing works
Görlich, D. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80015-4 · Cited by 297 · see citing works
Xu, X. N., Brownlow, W. J., Kyriacou, S. V., Wan, Q., & Viola, J. J. (2004) · Biochemistry · doi:10.1021/bi036231a · Cited by 296 · see citing works
Bergen, J. M., von Recum, H. A., Goodman, T. T., Massey, A. P., & Pun, S. H. (2006) · Macromolecular Bioscience · doi:10.1002/mabi.200600075 · Cited by 225 · see citing works
Intracellular uptake, transport, and processing of gold nanostructures
Chithrani, D. B. (2010) · Molecular Membrane Biology · doi:10.3109/09687688.2010.507787 · Cited by 211 · see citing works
A Temperature-Sensitive Liposomal 1H CEST and 19F Contrast Agent for MR Image-Guided Drug Delivery
Langereis, S., Keupp, J., van Velthoven, J. L. J., de Roos, I. H., Burdinski, D., Pikkemaat, J. A., & Grüll, H. (2009) · Journal of the American Chemical Society · doi:10.1021/ja8087532 · Cited by 167 · see citing works
Early diagnosis of oral cancer based on the surface plasmon resonance of gold nanoparticles.
Kah, J. C. Y., Kho, K. W., Lee, C. G. L., Sheppard, C. J. R., Sheppard, C. J. R., Shen, Z., Soo, K. C., & Olivo, M. (2007) · PubMed Central · Cited by 165 · see citing works
Gold Nanostructures as a Platform for Combinational Therapy in Future Cancer Therapeutics
Jelveh, S., & Chithrani, D. B. (2011) · Cancers · doi:10.3390/cancers3011081 · Cited by 152 · see citing works
Cellular uptake, evolution, and excretion of silica nanoparticles in human cells
Chu, Z., Huang, Y., Tao, Q., & Li, Q. (2011) · Nanoscale · doi:10.1039/c1nr10499c · Cited by 144 · see citing works
Cellular Uptake of Gold Nanoparticles Passivated with BSA−SV40 Large T Antigen Conjugates
Ryan, J. A., Overton, K. W., Speight, M. E., Oldenburg, C. N., Loo, L., Robarge, W. P., Franzen, S., & Feldheim, D. L. (2007) · Analytical Chemistry · doi:10.1021/ac0715524 · Cited by 120 · see citing works
Berry, C. C., de la Fuente, J. M., Mullin, M., Chu, S. W. L., & Curtis, A. S. G. (2007) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2007.908973 · Cited by 98 · see citing works
Shedding Light on Tumors Using Nanoparticles
Rao, J. (2008) · ACS Nano · doi:10.1021/nn800669n · Cited by 91 · see citing works
Shi, W., Wang, J., Fan, X., & Gao, H. (2008) · Physical Review E · doi:10.1103/physreve.78.061914 · Cited by 75 · see citing works
Viator, J. A., Gupta, S. K., Goldschmidt, B., Bhattacharyya, K., Kannan, R., Shukla, R., Dale, P. S., Boote, E., & Katti, K. V. (2010) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2010.1105 · Cited by 70 · see citing works
Bartczak, D., Sánchez-Elsner, T., Louafi, F., Millar, T. M., & Kanaras, A. G. (2010) · Small · doi:10.1002/smll.201001816 · Cited by 68 · see citing works
Nuclear pore complex biogenesis
Fernández-Martı́nez, J., & Rout, M. P. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.05.001 · Cited by 65 · see citing works
Cancer Nanotechnology: Enhanced Therapeutic Response Using Peptide-Modified Gold Nanoparticles
Yang, C. J., Neshatian, M., van Prooijen, M., & Chithrani, D. B. (2014) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2014.9280 · Cited by 45 · see citing works
Self-citationPavelka, M., & Roth, J. (2010) · Springer eBooks · doi:10.1007/978-3-211-99390-3 · Cited by 40 · see citing works
Flagged first, then by citations
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Sorted by citations
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine
Donahue, N. D., Acar, H., & Wilhelm, S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.04.008 · Cited by 962 · see citing works
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Her, S., Jaffray, D. A., & Allen, C. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.012 · Cited by 865 · see citing works
Augustine, R., Hasan, A., Primavera, R., Wilson, R. J., Thakor, A. S., & Kevadiya, B. D. (2020) · Materials Today Communications · doi:10.1016/j.mtcomm.2020.101692 · Cited by 569 · see citing works
Carbon dots: Biomacromolecule interaction, bioimaging and nanomedicine
Peng, Z., Han, X., Li, S., Al-Youbi, A. O., Bashammakh, A. S., El-Shahawi, M. S., & Leblanc, R. M. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.06.001 · Cited by 410 · see citing works
<p>Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy</p>
Chen, Y., Yang, J., Fu, S., & Wu, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272902 · Cited by 319 · see citing works
Advanced nanomaterials in oil and gas industry: Design, application and challenges
Khalil, M., Jan, B. M., Tong, C. W., & Berawi, M. A. (2017) · Applied Energy · doi:10.1016/j.apenergy.2017.01.074 · Cited by 300 · see citing works
Biological mechanisms of gold nanoparticle radiosensitization
Rosa, S., Connolly, C., Schettino, G., Butterworth, K. T., & Prise, K. M. (2017) · Cancer Nanotechnology · doi:10.1186/s12645-017-0026-0 · Cited by 258 · see citing works
Roadmap to Clinical Use of Gold Nanoparticles for Radiation Sensitization
Schuemann, J., Berbeco, R. I., Chithrani, D. B., Cho, S. H., Kumar, R., McMahon, S. J., Sridhar, S., & Krishnan, S. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.09.032 · Cited by 254 · see citing works
Yang, L., Jiang, W., Qiu, L., Jiang, X., Zuo, D., Wang, D., & Yang, L. (2015) · Nanoscale · doi:10.1039/c5nr01080b · Cited by 204 · see citing works
Off to the Organelles - Killing Cancer Cells with Targeted Gold Nanoparticles
Kodiha, M., Wang, Y. M., Hutter, E., Maysinger, D., & Stochaj, U. (2015) · Theranostics · doi:10.7150/thno.10657 · Cited by 174 · see citing works
Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
Guo, X., Xiao, W., Chen, Z., Zhang, X., Yang, G., & Zhou, S. (2019) · Progress in Materials Science · doi:10.1016/j.pmatsci.2019.100599 · Cited by 171 · see citing works
Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy
Kunjachan, S., Detappe, A., Kumar, R., Ireland, T. J., Cameron, L., Biancur, D. E., Motto‐Ros, V., Sancey, L., Sridhar, S., Makrigiorgos, G. M., et al. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b03073 · Cited by 153 · see citing works
RetractedColuccia, D., Figueiredo, C. A., Wu, M., Riemenschneider, A. N., Diaz, R. J., Luck, A. J., Smith, C. A., Das, S., Ackerley, C. A., O’Reilly, M. A., et al. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.01.021 · Cited by 141 · see citing works
In vitro outlook of gold nanoparticles in photo-thermal therapy: a literature review
Norouzi, H., Khoshgard, K., & Akbarzadeh, F. (2018) · Lasers in Medical Science · doi:10.1007/s10103-018-2467-z · Cited by 128 · see citing works
Cheng, Y., Sun, C., Ou, X., Liu, B., Lou, X., & Xia, F. (2017) · Chemical Science · doi:10.1039/c7sc00402h · Cited by 118 · see citing works
Chen, G., Xie, Y., Peltier, R., Lei, J. H., Wang, P., Chen, J., Hu, Y., Wang, F., Yao, X., & Sun, H. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b02594 · Cited by 110 · see citing works
How successful is nuclear targeting by nanocarriers?
Tammam, S. N., Azzazy, H. M. E.-S., & Lamprecht, A. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.03.022 · Cited by 108 · see citing works
Tammam, S. N., Azzazy, H. M. E.-S., Breitinger, H., & Lamprecht, A. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00478 · Cited by 97 · see citing works
In vitro and in vivo assessment of heart-homing porous silicon nanoparticles
Ferreira, M. P. A., Ranjan, S. K., Correia, A. M. R., Mäkilä, E. M., Kinnunen, S. M., Zhang, H., Shahbazi, M., Almeida, P. V., Salonen, J., Ruskoaho, H. J., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.046 · Cited by 91 · see citing works
Advances in the application of gold nanoparticles in bone tissue engineering
Li, H., Pan, S., Xia, P., Chang, Y., Fu, C., Kong, W., Yu, Z., Wang, K., Yang, X., & Qi, Z. (2020) · Journal of Biological Engineering · doi:10.1186/s13036-020-00236-3 · Cited by 87 · see citing works
Pandey, N. K., Chudal, L., Phan, J. B., Lin, L., Johnson, O., Xing, M., Liu, J. P., Li, H., Huang, X., Shu, Y., et al. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01566c · Cited by 84 · see citing works
Nanotechnology and immunoengineering: How nanotechnology can boost CAR-T therapy
Nawaz, W., Xu, S., Li, Y., Huang, B., Wu, X., & Wu, Z. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.04.015 · Cited by 81 · see citing works
Current and future technological advances in transdermal gene delivery
Chen, X. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.12.014 · Cited by 79 · see citing works
Al-Dulimi, A. G., Al‐Saffar, A. Z., Sulaiman, G. M., Khalil, K., Khashan, K. S., Al-Shmgani, H. S., & Ahmed, E. M. (2020) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2020.10.021 · Cited by 74 · see citing works
Chen, N., Song, Z., Tang, H., Xi, W., Cao, A., Liu, Y., & Wang, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060974 · Cited by 69 · see citing works
Özçiçek, İ., Ayşit, N., Çakici, Ç., & Aydeğer, A. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112308 · Cited by 67 · see citing works
Probing the biological obstacles of nanomedicine with gold nanoparticles
Li, B., & Lane, L. A. (2018) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1542 · Cited by 67 · see citing works
Austin, C. A., Hinkley, G. K., Mishra, A., Zhang, Q., Umbreit, T. H., Betz, M. W., Wildt, B., Casey, B. J., Francke‐Carroll, S., Hussain, S. M., et al. (2015) · Nanotoxicology · doi:10.3109/17435390.2015.1107143 · Cited by 65 · see citing works
Li, W. B., Belchior, A., Beuve, M., Chen, Y., Maria, S. D., Friedland, W., Gervais, B., Heide, B., Hocine, N., Ipatov, A. N., et al. (2020) · Physica Medica · doi:10.1016/j.ejmp.2019.12.011 · Cited by 64 · see citing works
Beaudet, D., Bǎdilescu, S., Kuruvinashetti, K., Kashani, A. S., Jaunky, D. B., Ouellette, S., Piekny, A. J., & Packirisamy, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-10872-3 · Cited by 61 · see citing works
Novel drug delivery systems: Insight into self-powered and nano-enabled drug delivery systems
Ewii, U. E., Onugwu, A. L., Nwokpor, V. C., Akpaso, I.-A., Ogbulie, T. E., Aharanwa, B., Chijioke, C., Verla, N., Iheme, C. I., Ujowundu, C. O., et al. (2024) · Nano TransMed · doi:10.1016/j.ntm.2024.100042 · Cited by 61 · see citing works
The promising potentials of capped gold nanoparticles for drug delivery systems
Khoshnevisan, K., Daneshpour, M., Barkhi, M., Gholami, M., Samadian, H., & Maleki, H. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1387790 · Cited by 59 · see citing works
Membrane Trafficking and Subcellular Drug Targeting Pathways
Kumar, A., Ahmad, A., Vyawahare, A., & Khan, R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00629 · Cited by 57 · see citing works
Gold nanoparticle mediated combined cancer therapy
Yang, C. J., Bromma, K., Ciano‐Oliveira, C. D., Zafarana, G., van Prooijen, M., & Chithrani, D. B. (2018) · Cancer Nanotechnology · doi:10.1186/s12645-018-0039-3 · Cited by 56 · see citing works
Self-citationThe Exploitation of Low-Energy Electrons in Cancer Treatment
Rezaee, M., Hill, R. P., & Jaffray, D. A. (2017) · Radiation Research · doi:10.1667/rr14727.1 · Cited by 54 · see citing works
Jasim, K. A., & Gesquiere, A. J. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00737 · Cited by 51 · see citing works
Modelling direct DNA damage for gold nanoparticle enhanced proton therapy
Sotiropoulos, M., Henthorn, N. T., Warmenhoven, J.-W., Mackay, R. I., Kirkby, K. J., & Merchant, M. J. (2017) · Nanoscale · doi:10.1039/c7nr07310k · Cited by 51 · see citing works
Youden, B., Jiang, R., Carrier, A. J., Servos, M. R., & Zhang, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c06337 · Cited by 51 · see citing works
Encapsulation of short-chain bioactive peptides (BAPs) for gastrointestinal delivery: a review
Atma, Y., Murray, B. S., Sadeghpour, A., & Goycoolea, F. M. (2024) · Food & Function · doi:10.1039/d3fo04195f · Cited by 49 · see citing works
Understanding the interactions between inorganic-based nanomaterials and biological membranes
Kang, Y., Liu, J., Jiang, Y., Yin, S., Huang, Z.-D., Zhang, Y., Wu, J., Chen, L., & Shao, L. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.030 · Cited by 48 · see citing works
Madni, A., Rehman, S., Sultan, H., Khan, M. M., Ahmad, F., Raza, M. R., Rai, N., & Parveen, F. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01873-z · Cited by 45 · see citing works
Yang, C. J., Bromma, K., & Chithrani, D. B. (2018) · Cancers · doi:10.3390/cancers10030084 · Cited by 44 · see citing works
Self-citationLiu, Y., Perumalsamy, H., Kang, C. H., Kim, S., Hwang, J., Koh, S., Yi, T., & Kim, Y.-J. (2020) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2020.1748639 · Cited by 43 · see citing works
Balusamy, S. R., Perumalsamy, H., Huq, M. A., Yoon, T. H., Mijakovic̀, I., Thangavelu, L. P., Yang, D., & Rahimi, S. (2023) · Medicinal Research Reviews · doi:10.1002/med.21953 · Cited by 42 · see citing works
Yao, C., Zhang, D., Wang, H., & Zhang, P. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071899 · Cited by 43 · see citing works
Biomedical applications of the peptide decorated gold nanoparticles
Rai, A., & Ferreira, L. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2020.1853031 · Cited by 42 · see citing works
Yang, C. J., Bromma, K., Sung, W., Schuemann, J., & Chithrani, D. B. (2018) · Cancers · doi:10.3390/cancers10050150 · Cited by 39 · see citing works
Self-citationBromma, K., Bannister, A., Kowalewski, A., Cicon, L., & Chithrani, D. B. (2020) · Cancer Nanotechnology · doi:10.1186/s12645-020-00064-6 · Cited by 38 · see citing works
Cell penetrating peptide grafting of PLGA nanoparticles to enhance cell uptake
Feiner‐Gracia, N., Dols-Pérez, A., Royo, M., Solans, C., García, M. J. N., & Fornaguera, C. (2018) · European Polymer Journal · doi:10.1016/j.eurpolymj.2018.09.026 · Cited by 37 · see citing works
Gold Nanoparticles for Radiation Enhancement in Vivo.
Shrestha, S., Cooper, L. N., Andreev, O. A., Reshetnyak, Y. K., & Antosh, M. P. (2016) · PubMed · Cited by 35 · see citing works
Colloidal Gold-Mediated Delivery of Bleomycin for Improved Outcome in Chemotherapy
Yang, C. J., Uertz, J., & Chithrani, D. B. (2016) · Nanomaterials · doi:10.3390/nano6030048 · Cited by 34 · see citing works
Self-citationHer, S., Cui, L., Bristow, R. G., & Allen, C. J. (2016) · Radiation Research · doi:10.1667/rr14315.1 · Cited by 34 · see citing works
Akhatova, F. S., Aleksandrovna, D. A., Yeşilay, G., Sarıçam, M., Çulha, M., & Fakhrullin, R. F. (2018) · Bulletin of the Chemical Society of Japan · doi:10.1246/bcsj.20180198 · Cited by 32 · see citing works
Bromma, K., Alhussan, A., Mesa-Perez, M., Howard, P. L., Beckham, W., & Chithrani, D. B. (2021) · Cancers · doi:10.3390/cancers13061465 · Cited by 32 · see citing works
SoRelle, E. D., Liba, O., Campbell, J. L., Dalal, R., Zavaleta, C. L., & de la Zerda, A. (2016) · eLife · doi:10.7554/elife.16352 · Cited by 31 · see citing works
Sobral-Filho, R. G., Brito‐Silva, A. M., Isabelle, M., Jirasek, A. I., Lum, J. J., & Brolo, A. G. (2017) · Chemical Science · doi:10.1039/c6sc04127b · Cited by 31 · see citing works
Zamora-Pérez, P., Pelaz, B., Tsoutsi, D., Soliman, M. G., Parak, W. J., & Rivera-Gil, P. (2021) · Nanoscale · doi:10.1039/d0nr08256b · Cited by 29 · see citing works
Bannister, A., Bromma, K., Sung, W., Mesa-Perez, M., Cicon, L., Howard, P. L., Chow, R. L., Schuemann, J., & Chithrani, D. B. (2019) · British Journal of Radiology · doi:10.1259/bjr.20190742 · Cited by 30 · see citing works
Cellular Alterations Due to Direct and Indirect Interaction of Nanomaterials with Nucleic Acids
Encinas‐Giménez, M., Martín‐Duque, P., & Martín-Pardillos, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25041983 · Cited by 29 · see citing works
Alhussan, A., Bozdoğan, E. P. D., & Chithrani, D. B. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040442 · Cited by 29 · see citing works
Tailoring nanoparticles for targeted drug delivery: From organ to subcellular level
Liang, T., Xing, Z., Jiang, L., & Zhu, J. (2021) · Open Research (University of Surrey) · doi:10.1002/viw.20200131 · Cited by 29 · see citing works
Alhussan, A., Bromma, K., Mesa-Perez, M., Beckham, W., Alexander, A., Howard, P. L., & Chithrani, D. B. (2021) · Cancers · doi:10.3390/cancers13133157 · Cited by 29 · see citing works
Influence of Nuclear Localization Sequences on the Intracellular Fate of Gold Nanoparticles
Drescher, D., Büchner, T., Schrade, P., Traub, H., Werner, S., Guttmann, P., Bachmann, S., & Kneipp, J. (2021) · ACS Nano · doi:10.1021/acsnano.1c04925 · Cited by 28 · see citing works
Cifter, G., Chin, J., Cifter, F., Altundal, Y., Sinha, N., Sajo, E., & Ngwa, W. F. (2015) · Physica Medica · doi:10.1016/j.ejmp.2015.07.138 · Cited by 27 · see citing works
Kalmodia, S., Parameswaran, S., Ganapathy, K., Yang, W. R., Barrow, C. J., Kanwar, J. R., Roy, K., Vasudevan, M., Kulkarni, K., Elchuri, S. V., et al. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.10.012 · Cited by 27 · see citing works
Strategies to target bioactive molecules to subcellular compartments. Focus on natural compounds
Biasutto, L., Mattarei, A., Spina, M. L., Azzolini, M., Parrasia, S., Szabó, I., & Zoratti, M. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.07.060 · Cited by 26 · see citing works
Khan, H. A., Ibrahim, K. E., Khan, A., Alrokayan, S., Alhomida, A. S., & Lee, Y.-K. (2016) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2016.05.006 · Cited by 25 · see citing works
Cui, P., Qi, L., Wang, Y., Yu, R.-Y., He, Y., Xing, L., & Jiang, H. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.035 · Cited by 25 · see citing works
Li, W. B., Stangl, S., Klapproth, A. P., Shevtsov, M. A., Hernandez, A., Kimm, M. A., Schuemann, J., Qiu, R., Michalke, B., Bernal, M. A., et al. (2021) · Cancers · doi:10.3390/cancers13215370 · Cited by 25 · see citing works
Research progress in nucleus-targeted tumor therapy
Chen, S., Cao, R., Xiang, L., Li, Z., Chen, H., Zhang, J., & Feng, X. (2023) · Biomaterials Science · doi:10.1039/d3bm01116j · Cited by 25 · see citing works
Amphiphilic peptide coated superparamagnetic iron oxide nanoparticles for in vivo MR tumor imaging
Özdemir, A., Ekiz, M. Ş., Dilli, A., Guler, M. O., & Tekinay, A. B. (2016) · RSC Advances · doi:10.1039/c6ra07380h · Cited by 23 · see citing works
Liu, R., Zhao, T., Zhao, X., & Reynoso, F. J. (2019) · Medical Physics · doi:10.1002/mp.13813 · Cited by 22 · see citing works
Alhussan, A., Palmerley, N., Smazynski, J., Karasinska, J. M., Renouf, D. J., Schaeffer, D. F., Beckham, W., Alexander, A., & Chithrani, D. B. (2022) · Cancers · doi:10.3390/cancers14153586 · Cited by 21 · see citing works
State-of-art based approaches for anticancer drug-targeting to nucleus
Tiwari, R., Jain, P., Asati, S., Haider, T., Soni, V., & Pandey, V. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.10.011 · Cited by 20 · see citing works
In vivo immunological response of exposure to PEGylated graphene oxide via intraperitoneal injection
Ding, Z., Luo, N., Yue, H., Gao, Y., Ma, G., & Wei, W. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00499e · Cited by 20 · see citing works
Pan, Y., Weng, R., Zhang, L., Qiu, J., Wang, X., Liao, G., Qin, Z. S., Zhang, L., Xiao, H., Qian, Y., et al. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101573 · Cited by 20 · see citing works
Jackson, N., Hill, I., Alhussan, A., Bromma, K., Morgan, J., Abousaida, B., Zahra, Y., Mackeyev, Y., Beckham, W., Herchko, S. M., et al. (2023) · Cancer Nanotechnology · doi:10.1186/s12645-023-00228-0 · Cited by 20 · see citing works
Imaging intracellular and systemicin vivogold nanoparticles to enhance radiotherapy
Botchway, S. W., Coulter, J. A., & Currell, F. J. (2015) · British Journal of Radiology · doi:10.1259/bjr.20150170 · Cited by 19 · see citing works
Yang, Y., Ren, L., & Wang, H. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0049 · Cited by 19 · see citing works
Uddin, M. I., Jayagopal, A., Wong, A. C., McCollum, G. W., Wright, D. W., & Penn, J. S. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.08.018 · Cited by 19 · see citing works
Nicol, J. R., Harrison, E., O'Neill, S. M., Dixon, D., McCarthy, H. O., & Coulter, J. A. (2018) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2017.11.019 · Cited by 18 · see citing works
Effects of macrophage polarization on gold nanoparticle-assisted plasmonic photothermal therapy
Ali, H. R. K., Selim, S. A. K., & Aili, D. (2021) · RSC Advances · doi:10.1039/d1ra03671h · Cited by 18 · see citing works
Oral delivery of polyester nanoparticles for brain-targeting: Challenges and opportunities
Wang, P., Wang, Y., Li, P., Chen, C., Ma, S., Zhao, L., He, H., Yin, T., Zhang, Y. X., Tang, X., et al. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.07.034 · Cited by 18 · see citing works
An overview of the intracellular localization of high-Z nanoradiosensitizers
Varzandeh, M., Labbaf, S., Varshosaz, J., & Laurent, S. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.08.006 · Cited by 17 · see citing works
Alhussan, A., Bromma, K., Bozdoğan, E. P. D., Metcalfe, A. L., Karasinska, J. M., Beckham, W., Alexander, A., Renouf, D. J., Schaeffer, D. F., & Chithrani, D. B. (2021) · Current Oncology · doi:10.3390/curroncol28030183 · Cited by 17 · see citing works
Nanotechnology Meets the Tumor Microenvironment: Unlocking New Horizons in Cancer Therapy
Yadav, P., Yadav, A. K., & Bhatia, D. D. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c01120 · Cited by 16 · see citing works
Alhussan, A., Jackson, N., Eaton, S., Santos, N. D., Barta, I., Zaifman, J., Chen, S., Tam, Y. Y. C., Krishnan, S., & Chithrani, D. B. (2022) · Cancers · doi:10.3390/cancers14246137 · Cited by 15 · see citing works
Uddin, M. I., Kilburn, T. C., Yang, R., McCollum, G. W., Wright, D. W., & Penn, J. S. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00661 · Cited by 15 · see citing works
Özçiçek, İ. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118410 · Cited by 15 · see citing works
Jackson, N., Bouzeineddine, N. Z., Cecchi, D. D., Holder, S., Gee, K., Beckham, W., Basta, S., Krishnan, S., & Chithrani, D. B. (2025) · Scientific Reports · doi:10.1038/s41598-025-22151-7 · Cited by 14 · see citing works
Facile Synthesis of Peptide-Conjugated Gold Nanoclusters with Different Lengths
Ma, Q., Liu, L., Yang, Z., & Zheng, P. (2021) · Nanomaterials · doi:10.3390/nano11112932 · Cited by 14 · see citing works
Alhussan, A., Jackson, N., Chow, N. S., Gete, E., Wretham, N., Santos, N. D., Beckham, W., Duzenli, C., & Chithrani, D. B. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16060713 · Cited by 14 · see citing works
Intracellular Localized Surface Plasmonic Sensing for Subcellular Diagnosis
Kuruvinashetti, K., Kashani, A. S., Bǎdilescu, S., Beaudet, D., Piekny, A. J., & Packirisamy, M. (2017) · Plasmonics · doi:10.1007/s11468-017-0673-3 · Cited by 14 · see citing works
Borbolla‐Jiménez, F. V., Prado-Audelo, M. L. D., Cisneros, B., Caballero-Florán, I. H., Leyva‐Gómez, G., & Magaña, J. J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071018 · Cited by 13 · see citing works
Desplancq, D., Groysbeck, N., Chiper, M., Weiss, É., Frisch, B., Strub, J., Cianférani, S., Zafeiratos, S., Moeglin, É., Holy, X., et al. (2018) · ACS Applied Nano Materials · doi:10.1021/acsanm.8b00988 · Cited by 12 · see citing works
Oladipo, A. O., Unuofin, J. O., Iku, S. I. I., Nkambule, T. T. I., Mamba, B. B., & Msagati, T. A. M. (2021) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2021.103344 · Cited by 11 · see citing works
Dark-Field Microscopic Study of Cellular Uptake of Carbon Nanodots: Nuclear Penetrability
Zhang, W., Ji, Z., Zeng, Z., Jayapalan, A., Bagra, B., Sheardy, A. T., He, P., LaJeunesse, D., & Wei, J. (2022) · Molecules · doi:10.3390/molecules27082437 · Cited by 11 · see citing works
Cellular response to nanobiomaterials
Augustine, R., & Hasan, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102967-1.00022-0 · Cited by 11 · see citing works
Han, O., Bromma, K., Palmerley, N., Bido, A. T., Mesa-Perez, M., Alhussan, A., Howard, P. L., Brolo, A. G., Beckham, W., Alexander, A., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020233 · Cited by 11 · see citing works
- Authors
- Yang, C., Uertz, J., Yohan, D., & Chithrani, B. D.
- Affiliations
- Toronto Metropolitan University (CA)
- CytoVivaInc
- Department of Physics
- ORCID
- Yang, C.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 6
- Issue
- 20
- Pages
- 12026-12033
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2140808108
- Cited by
- 156
- References
- 43
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 36 · 2020: 13 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 12 · 2015: 10
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- gold nanoparticles, peptide functionalization, RGD peptide, cellular uptake, nuclear transport, intracellular retention, plasma protein binding, citrate-capped nanoparticles, anticancer drug delivery
- MeSH terms
- Animals, Cattle, Cell Nucleus, Drug Carriers, Endocytosis, Exocytosis, Gold, HeLa Cells, Humans, Oligopeptides, Peptides, Endosomes, Serum Albumin, Surface Properties, Citric Acid, Active Transport, Cell Nucleus, Nuclear Pore, Nanotechnology, Microscopy, Electron, Transmission, Metal Nanoparticles
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