Cited by 156Nanoparticle-Based Drug DeliveryGold and Silver Nanoparticles Synthesis and ApplicationsRNA Interference and Gene Delivery

Peptide modified gold nanoparticles for improved cellular uptake, nuclear transport, and intracellular retention

Yang, C., Uertz, J., Yohan, D., Chithrani, B. D.·2014·Nanoscale

Abstract

A novel hyperspectral imaging technique is used to image GNPs: a combination of three peptides is used for efficient nuclear targeting and improved retention of GNPs targeted into the nucleus is shown for the first time. This is important for future cancer therapeutics as GNPs can be used as radiation dose enhancers and anticancer drug carriers.

Integrity signals

Registry

Crossref · 10.1039/c4nr02535k

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43 of 43 references verified0 citation errors · 0 not checkable

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  • Tripeptide modification of gold nanoparticles shows 5-fold NP uptake and effective nuclear localization.

    “The modification of the tripeptide showed a 5-fold NP uptake and effective nuclear localization.236”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [236]

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Authors
Yang, C., Uertz, J., Yohan, D., & Chithrani, B. D.
Affiliations
  • Toronto Metropolitan University (CA)
  • CytoVivaInc
  • Department of Physics
Venue
Nanoscale
Published
2014
Volume
6
Issue
20
Pages
12026-12033
ISSN
  • 2040-3364 (ISSN-L)
  • 2040-3372
OpenAlex
W2140808108
Cited by
156
References
43
Citations by year
2026: 5 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 36 · 2020: 13 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 12 · 2015: 10
FWCI
5.05
Type
journal article
Language
en
Open access
closed
Locations
  • Nanoscale (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Sciences and Engineering Research Council of Canada
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
gold nanoparticles, peptide functionalization, RGD peptide, cellular uptake, nuclear transport, intracellular retention, plasma protein binding, citrate-capped nanoparticles, anticancer drug delivery
MeSH terms
Animals, Cattle, Cell Nucleus, Drug Carriers, Endocytosis, Exocytosis, Gold, HeLa Cells, Humans, Oligopeptides, Peptides, Endosomes, Serum Albumin, Surface Properties, Citric Acid, Active Transport, Cell Nucleus, Nuclear Pore, Nanotechnology, Microscopy, Electron, Transmission, Metal Nanoparticles

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