Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery
Abstract
Abstract Cell‐penetrating peptides (CPPs) including TAT peptide (TATp) have been successfully used for intracellular delivery of a broad variety of cargos including various nanoparticulate pharmaceutical carriers (liposomes, micelles, nanoparticles). Here, we will consider the main results in this area, with a special emphasis on TATp‐mediated delivery of liposomes and DNA. We will also address the development of “smart” stimuli‐sensitive nanocarriers, where cell‐penetrating function can be activated by the decreased pH only inside the biological target minimizing thus the interaction of drug‐loaded nanocarriers with nontarget cells. © 2008 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 604–610, 2008. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
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Cell penetrating peptides such as TAT and R8 have been extensively used to facilitate cell entry based on positive charge and amphipathic nature.
“Besides, cell penetrating peptides (CPP), such as TAT and R8 peptide, have also been extensively used to facilitate cell entry based on the positive charge and amphipathic in nature [174, 175].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [175]
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- Authors
- Torchilin, V. P.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Torchilin, Vladimir P.
- Venue
- Peptide Science
- Publisher
- Wiley
- Published
- 2008-01
- Volume
- 90
- Issue
- 5
- Pages
- 604-610
- ISSN
- 0006-3525 (ISSN-L)
- OpenAlex
- W2162355697
- Cited by
- 283
- References
- 61
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 12 · 2023: 12 · 2022: 11 · 2021: 11 · 2020: 15 · 2019: 12 · 2018: 21 · 2017: 14 · 2016: 15 · 2015: 23 · 2014: 19 · 2013: 26 · 2012: 26
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biopolymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL55519, R01HL055519)
- National Institute of Biomedical Imaging and Bioengineering (R01EB001961)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- cell-penetrating peptides, TAT peptide, intracellular drug delivery, gene delivery, liposomes, micelles, nanoparticles, pH-responsive delivery, targeted drug delivery
- MeSH terms
- Animals, DNA, Drug Carriers, Humans, Intracellular Fluid, Liposomes, Peptides, Gene Transfer Techniques, Nanoparticles, tat Gene Products, Human Immunodeficiency Virus
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