The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Promises and Pitfalls of Intracellular Delivery of Proteins
Open accessAbstract
The direct delivery of functional proteins into the cell cytosol is a key issue for protein therapy, with many current strategies resulting in endosomal entrapment. Protein delivery to the cytosol is challenging due to the high molecular weight and the polarity of therapeutic proteins. Here we review strategies for the delivery of proteins into cells, including cell-penetrating peptides, virus-like particles, supercharged proteins, nanocarriers, polymers, and nanoparticle-stabilized nanocapsules. The advantages and disadvantages of these approaches including cytosolar delivery are compared and contrasted, with promising pathways forward identified.
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Cites
Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
Gaj, T., Guo, J., Kato, Y., Sirk, S. J., & Barbas, C. F. (2012) · Nature Methods · doi:10.1038/nmeth.2030 · Cited by 306
Tang, R., Kim, C. S., Solfiell, D. J., Rana, S., Mout, R., Velázquez-Delgado, E. M., Chompoosor, A., Jeong, Y., Yan, B., Zhu, Z.-J., et al. (2013) · ACS Nano · doi:10.1021/nn402753y · Cited by 188
Self-citationOral delivery of peptides and proteins using lipid-based drug delivery systems
Li, P., Nielsen, H. M., & Müllertz, A. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.717068 · Cited by 116
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Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 747
Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
Wang, M., Zuris, J. A., Meng, F., Rees, H., Sun, S., Deng, P., Han, Y., Gao, X., Pouli, D., Wu, Q., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520244113 · Cited by 624
Boronic acids as building blocks for the construction of therapeutically useful bioconjugates
António, J. P. M., Russo, R., Carvalho, C. P., Cal, P. M. S. D., & Gois, P. M. P. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00184k · Cited by 303
Magnetic Nanoparticles in Targeted Drug Delivery: a Review
kianfar, E. (2021) · Journal of Superconductivity and Novel Magnetism · doi:10.1007/s10948-021-05932-9 · Cited by 280
Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies
Scaletti, F., Hardie, J., Lee, Y.-W., Luther, D. C., Ray, M., & Rotello, V. M. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00008e · Cited by 208
Self-citationThe Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics
Qian, L., Lin, X., Gao, X., Khan, R. U., Liao, J.-Y., Du, S., Ge, J., Zeng, S., & Yao, S. Q. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00915 · Cited by 155
He, X., Long, Q., Zeng, Z., Yang, L., Tang, Y., & Feng, X. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201906187 · Cited by 29
Metadata
- Authors
- Fu, A., Tang, R., Hardie, J., Farkas, M. E., & Rotello, V. M.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-09-02
- Volume
- 25
- Issue
- 9
- Pages
- 1602-1608
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2330923532
- Cited by
- 306
- References
- 4
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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