The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Unnatural Amino Acid Incorporation into Virus-Like Particles
Open accessAbstract
Virus-like particles composed of hepatitis B virus (HBV) or bacteriophage Qbeta capsid proteins have been labeled with azide- or alkyne-containing unnatural amino acids by expression in a methionine auxotrophic strain of E. coli. The substitution does not affect the ability of the particles to self-assemble into icosahedral structures indistinguishable from native forms. The azide and alkyne groups were addressed by Cu(I)-catalyzed [3 + 2] cycloaddition: HBV particles were decomposed by the formation of more than 120 triazole linkages per capsid in a location-dependent manner, whereas Qbeta suffered no such instability. The marriage of these well-known techniques of sense-codon reassignment and bioorthogonal chemical coupling provides the capability to construct polyvalent particles displaying a wide variety of functional groups with near-perfect control of spacing.
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Cites
Tornøe, C. W., Christensen, C., & Meldal, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo011148j · Cited by 8,696
A General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins
Noren, C. J., Anthony-Cahill, S. J., Griffith, M. C., & Schultz, P. G. (1989) · Science · doi:10.1126/science.2649980 · Cited by 1,019 · cited 4×
“The three most common approaches are the use of a nonsense or rare codon (1-8), the use of a larger (quadruplet) codon (4,9), or the reassignment of a sense codon (10-17).”
BackgroundMethodInfluentialDieterich, D. C., Link, A. J., Graumann, J., Tirrell, D. A., & Schuman, E. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601637103 · Cited by 874
Self-citationNon-canonical amino acids in protein engineering
Link, A. J., Mock, M. L., & Tirrell, D. A. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.10.011 · Cited by 393
Self-citation
Cited by
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
Sletten, E. M., & Bertozzi, C. R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900942 · Cited by 3,165
Algar, W. R., Prasuhn, D. E., Stewart, M. H., Jennings, T. L., Blanco-Canosa, J. B., Dawson, P. E., & Medintz, I. L. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200065z · Cited by 502
Self-citationJohnson, J. A., Lu, Y. Y., Van Deventer, J. A., & Tirrell, D. A. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.09.013 · Cited by 323
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Metadata
- Authors
- Strable, E., Prasuhn, D. E., Udit, A. K., Brown, S., Link, A. J., Ngo, J. T., Lander, G., Quispe, J., Potter, C. S., Carragher, B., Tirrell, D. A., & Finn, M. G.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-03-05
- Volume
- 19
- Issue
- 4
- Pages
- 866-875
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2085048677
- Cited by
- 181
- References
- 4
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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