The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
General mechanism for the bacterial toxicity of hypochlorous acid: abolition of ATP production
Abstract
The adenylate energy charges (EC) of Escherichia coli 25922, Pseudomonas aeruginosa 27853, and Streptococcus lactis 7962 rapidly fell in nutrient-rich media from values in excess of 0.9 to below 0.1 when the organisms were exposed to lethal levels of HOCl. The same cells maintained in energy-depleted states were incapable of attaining normal EC values necessary for biosynthesis and growth when challenged with nutrient energy sources after HOCl exposure. These changes correlated quantitatively with loss of replicative capabilities. Initial rates of transport of glucose, succinate, and various amino acids that act as respiratory substrates and the ATP hydrolase activity of the F1 complex from the ATP synthase of E. coli 25922 also declined in parallel with or preceded loss of viability. These results establish that cellular death is accompanied by complete disruption of bacterial ATP production by both oxidative and fermentative pathways as a consequence of inhibition of inner membrane bound systems responsible for these processes.
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Albrich, J. M., McCarthy, C. A., & Hurst, J. K. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.1.210 · Cited by 442
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Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils
Rosen, H., Klebanoff, S. J., Wang, Y., Brot, N., Heinecke, J. W., & Fu, X. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909464106 · Cited by 154
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Hurst, J. K. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.008 · Cited by 124
Self-citationSevering, A.-L., Rembe, J.-D., Koester, V., & Stuermer, E. K. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky432 · Cited by 120
Metadata
- Authors
- Barrette, W. C., Hannum, D. M., Wheeler, W. D., & Hurst, J. K.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1989-11-14
- Volume
- 28
- Issue
- 23
- Pages
- 9172-9178
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2048963959
- Cited by
- 190
- References
- 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
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