Redox Reactions and Microbial Killing in the Neutrophil Phagosome

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works

Neutrophil Extracellular Traps Kill Bacteria

Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works

Free Radicals in Biology and Medicine

Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990 · see citing works

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works

NOX enzymes and the biology of reactive oxygen

Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125 · see citing works

Neutrophils and immunity: challenges and opportunities

Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971 · see citing works

Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent

Babior, B. M., Kipnes, R. S., & Curnutte, J. T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107236 · Cited by 2,931 · see citing works

Reconciling the chemistry and biology of reactive oxygen species

Winterbourn, C. C. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.85 · Cited by 2,504 · see citing works

Myeloperoxidase: friend and foe

Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282 · see citing works

Pathways of Oxidative Damage

Imlay, J. A. (2003) · Annual Review of Microbiology · doi:10.1146/annurev.micro.57.030502.090938 · Cited by 2,206 · see citing works

HOW NEUTROPHILS KILL MICROBES

Segal, A. W. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115653 · Cited by 1,783 · see citing works

Chronic Granulomatous Disease: Report on a National Registry of 368 Patients

Winkelstein, J. A., Marino, M. C., Johnston, R. B., Boyle, J., Curnutte, J., Gallin, J. I., Malech, H. L., Holland, S. M., Ochs, H., Quie, P., et al. (2000) · Medicine · doi:10.1097/00005792-200005000-00003 · Cited by 1,728 · see citing works

Antimicrobial reactive oxygen and nitrogen species: concepts and controversies

Fang, F. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1004 · Cited by 1,676 · see citing works

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998) · Blood · doi:10.1182/blood.v92.9.3007.421k47_3007_3017 · Cited by 1,640 · see citing works

Glucose-6-phosphate dehydrogenase deficiency

Cappellini, M., & Fiorelli, G. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60073-2 · Cited by 1,590 · see citing works

Cellular Defenses against Superoxide and Hydrogen Peroxide

Imlay, J. A. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061606.161055 · Cited by 1,563 · see citing works

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536 · see citing works

Granules of the Human Neutrophilic Polymorphonuclear Leukocyte

Borregaard, N., & Cowland, J. B. (1997) · Blood · doi:10.1182/blood.v89.10.3503 · Cited by 1,514 · see citing works

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., & van der Vliet, A. (1998) · Nature · doi:10.1038/34923 · Cited by 1,496 · see citing works

How super is superoxide?

Sawyer, D. T., & Valentine, J. S. (1981) · Accounts of Chemical Research · doi:10.1021/ar00072a005 · Cited by 1,352 · see citing works

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

Reeves, E. P., Lu, H., Jacobs, H. L., Messina, C. G. M., Bolsover, S., Gabella, G., Potma, E. O., Warley, A., Roes, J., & Segal, A. W. (2002) · Nature · doi:10.1038/416291a · Cited by 1,153 · see citing works

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

Ischiropoulos, H. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0755 · Cited by 1,024 · see citing works

Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms

Urban, C. F., Reichard, U., Brinkmann, V., & Zychlinsky, A. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00659.x · Cited by 1,014 · see citing works

Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity

Allen, R. C., STJERNHOLM, R. L., & Steele, R. H. (1972) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(72)90545-1 · Cited by 960 · see citing works

Genetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease

Segal, B. H., Leto, T. L., Gallin, J. I., Malech, H. L., & Holland, S. M. (2000) · Medicine · doi:10.1097/00005792-200005000-00004 · Cited by 877 · see citing works

Nox proteins in signal transduction

Brown, D. I., & Griendling, K. (2009) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2009.07.023 · Cited by 841 · see citing works

Chlorination of Taurine by Human Neutrophils

Weiss, S. J., Klein, R., Slivka, A., & Wei, M. L. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110652 · Cited by 806 · see citing works

Absolute Rate Constants for the Reaction of Hypochlorous Acid with Protein Side Chains and Peptide Bonds

Pattison, D. I., & Davies, M. J. (2001) · Chemical Research in Toxicology · doi:10.1021/tx0155451 · Cited by 790 · see citing works

Chemical biology of peroxynitrite: Kinetics, diffusion, and radicals

Ferrer-Sueta, G., & Radi, R. (2009) · ACS Chemical Biology · doi:10.1021/cb800279q · Cited by 776 · cited 1× · see citing works

How human neutrophils kill and degrade microbes: an integrated view

Nauseef, W. M. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00550.x · Cited by 756 · see citing works

Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase

Eiserich, J. P., Baldus, S. E., Brennan, M., Ma, W., Zhang, C., Tousson, A., Castro, L., Lusis, A. J., Nauseef, W. M., White, C. R., et al. (2002) · Science · doi:10.1126/science.1106830 · Cited by 685 · see citing works

Myeloperoxidase: a key regulator of neutrophil oxidant production

Kettle, A. J., & Winterbourn, C. C. (1997) · Redox Report · doi:10.1080/13510002.1997.11747085 · Cited by 660 · see citing works

H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.

Root, R. K., Metcalf, J. A., Oshino, N., & Chance, B. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108024 · Cited by 646 · see citing works

Modeling the Reactions of Superoxide and Myeloperoxidase in the Neutrophil Phagosome

Winterbourn, C. C., Hampton, M. B., Livesey, J. H., & Kettle, A. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605898200 · Cited by 633 · see citing works

Inflammation: Basic Principles and Clinical Correlates

Ehrlich, G. E. (2000) · JAMA · doi:10.1001/jama.283.1.123 · Cited by 624 · see citing works

Development of an Si-Rhodamine-Based Far-Red to Near-Infrared Fluorescence Probe Selective for Hypochlorous Acid and Its Applications for Biological Imaging

Koide, Y., Urano, Y., Hanaoka, K., Terai, T., & Nagano, T. (2011) · Journal of the American Chemical Society · doi:10.1021/ja111470n · Cited by 576 · see citing works

Mammalian Heme Peroxidases: From Molecular Mechanisms to Health Implications

Davies, M. J., Hawkins, C. L., Pattison, D. I., & Rees, M. D. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1927 · Cited by 556 · see citing works

A Cholesterol Biosynthesis Inhibitor Blocks <i>Staphylococcus aureus</i> Virulence

Liu, C.-I., Liu, G. Y., Song, Y., Yin, F., Hensler, M. E., Jeng, W.-Y., Nizet, V., Wang, A. H.-J., & Oldfield, E. (2008) · Science · doi:10.1126/science.1153018 · Cited by 490 · see citing works

Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages.

Heinecke, J. W., Li, W., Daehnke, H. L., & Goldstein, J. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53581-x · Cited by 485 · see citing works

Free radicals and phagocytic cells

Rosen, G. M., Pou, S., Ramos, C. L., Cohen, M. S., & Britigan, B. E. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7540156 · Cited by 478 · see citing works

Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of oxidant to hypochlorite

Winterbourn, C. C. (1985) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(85)90120-5 · Cited by 463 · see citing works

Development of a Highly Specific Rhodamine-Based Fluorescence Probe for Hypochlorous Acid and Its Application to Real-Time Imaging of Phagocytosis

Kenmoku, S., Urano, Y., Kojima, H., & Nagano, T. (2007) · Journal of the American Chemical Society · doi:10.1021/ja068740g · Cited by 462 · see citing works

Formation of Nitrating and Chlorinating Species by Reaction of Nitrite with Hypochlorous Acid

Eiserich, J. P., Cross, C. E., Jones, A. D., Halliwell, B., & van der Vliet, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.32.19199 · Cited by 447 · see citing works

Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase.

Albrich, J. M., McCarthy, C. A., & Hurst, J. K. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.1.210 · Cited by 442 · see citing works

The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH

Segal, A. W., Geisow, M. J., Garcia, R. C., Harper, A., & Miller, R. F. (1981) · Nature · doi:10.1038/290406a0 · Cited by 422 · see citing works

Thiocyanate and chloride as competing substrates for myeloperoxidase

van DALEN, J. C., WHITEHOUSE, W. M., WINTERBOURN, C. C., & KETTLE, J. A. (1997) · Biochemical Journal · doi:10.1042/bj3270487 · Cited by 406 · see citing works

Nitric Oxide Is a Physiological Substrate for Mammalian Peroxidases

Abu‐Soud, H. M., & Hazen, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.48.37524 · Cited by 398 · see citing works

Biomarkers of myeloperoxidase-derived hypochlorous acid

Winterbourn, C. C., & Kettle, A. J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00204-5 · Cited by 390 · see citing works

X-ray Crystal Structure and Characterization of Halide-binding Sites of Human Myeloperoxidase at 1.8 Å Resolution

Fiedler, T. J., Davey, C. A., & Fenna, R. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11964 · Cited by 374 · see citing works

Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation

Sheppard, F. R., Kelher, M. R., Moore, E. E., McLaughlin, N. J. D., Banerjee, A. M., & Silliman, C. C. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0804442 · Cited by 374 · see citing works

Permeation of the erythrocyte stroma by superoxide radical

Lynch, R. E., & Fridovich, I. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30446-5 · Cited by 370 · see citing works

Absence of Respiratory Burst in X-linked Chronic Granulomatous Disease Mice Leads to Abnormalities in Both Host Defense and Inflammatory Response to <i>Aspergillus fumigatus</i>

Morgenstern, D. E., Gifford, M. A. C., Li, L. L., Doerschuk, C. M., & Dinauer, M. C. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.2.207 · Cited by 370 · see citing works

Bimodal pattern of killing of DNA-repair-defective or anoxically grown Escherichia coli by hydrogen peroxide

Imlay, J. A., & Linn, S. (1986) · Journal of Bacteriology · doi:10.1128/jb.166.2.519-527.1986 · Cited by 361 · see citing works

Chronic Granulomatous Disease

(2012) · SpringerReference · doi:10.1007/springerreference_172807 · Cited by 360 · see citing works

Reactions of Myeloperoxidase-Derived Oxidants with Biological Substrates:Gaining Chemical Insight into Human Inflammatory Diseases

Pattison, D. I., & Davies, M. J. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706778773095 · Cited by 359 · see citing works

Active site structure and catalytic mechanisms of human peroxidases

Furtmüller, P. G., Zederbauer, M., Jantschko, W., Helm, J., Bogner, M., Jakopitsch, C., & Obinger, C. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.09.017 · Cited by 358 · see citing works

Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation

Wentworth, P., McDunn, J. E., Wentworth, A. D., Takeuchi, C., Nieva, J. J., Jones, T., Bautista, C., Ruedi, J. M., Gutierrez, A., Janda, K. D., et al. (2002) · Science · doi:10.1126/science.1077642 · Cited by 349 · see citing works

[40] Preparation and characterization of chloramines

Thomas, E. L., Grisham, M. B., & Jefferson, M. M. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(86)32042-1 · Cited by 348 · see citing works

Myeloperoxidase: Contribution to the Microbicidal Activity of Intact Leukocytes

Klebanoff, S. J. (1970) · Science · doi:10.1126/science.169.3950.1095 · Cited by 347 · see citing works

Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases

Leto, T. L., Morand, S. C., Hurt, D. E., & Ueyama, T. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2637 · Cited by 343 · see citing works

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

Parker, H. A., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0711387 · Cited by 342 · see citing works

Involvement of Reactive Oxygen Intermediates in Spontaneous and CD95(Fas/APO-1)–Mediated Apoptosis of Neutrophils

Kasahara, Y., Iwai, K., Yachie, A., Ohta, K., Konno, A., Seki, H., Miyawaki, T., & Taniguchi, N. (1997) · Blood · doi:10.1182/blood.v89.5.1748 · Cited by 339 · see citing works

Mechanisms of chlorine oxidation of hydrogen peroxide

Held, A. M., Halko, D. J., & Hurst, J. K. (1978) · Journal of the American Chemical Society · doi:10.1021/ja00486a025 · Cited by 339 · see citing works

Kinetics of the reactions of hypochlorous acid and amino acid chloramines with thiols, methionine, and ascorbate

Peskin, A. V., & Winterbourn, C. C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00506-2 · Cited by 338 · see citing works

DEGRANULATION OF POLYMORPHONUCLEAR LEUCOCYTES FOLLOWING PHAGOCYTOSIS OF MICROORGANISMS

Hirsch, J. G., & Cohn, Z. A. (1960) · The Journal of Experimental Medicine · doi:10.1084/jem.112.6.1005 · Cited by 335 · see citing works

Chlorination of Tyrosyl Residues in Peptides by Myeloperoxidase and Human Neutrophils

Domigan, N. M., Charlton, T. S., Duncan, M. W., Winterbourn, C. C., & Kettle, A. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16542 · Cited by 329 · see citing works

NADPH Oxidase Activation and Assembly During Phagocytosis

DeLeo, F. R., Allen, L. H., Apicella, M. A., & Nauseef, W. M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6732 · Cited by 313 · see citing works

Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria.

Evans, T. J., Buttery, L. D. K., Carpenter, A., Springall, D. R., Polak, J. M., & Cohen, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9553 · Cited by 311 · see citing works

Molecular basis of chronic granulomatous disease [see comments]

Rm, S., & Curnutte, J. T. (1991) · Blood · doi:10.1182/blood.v77.4.673.bloodjournal774673 · Cited by 298 · see citing works

Bacterial infection induces nitric oxide synthase in human neutrophils.

Wheeler, M. A., Smith, S. D., García‐Cardeña, G., Nathan, C., Weiss, R. M., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119121 · Cited by 296 · see citing works

Reaction of Myeloperoxidase Compound I with Chloride, Bromide, Iodide, and Thiocyanate

Furtmüller, P. G., Burner, U., & Obinger, C. (1998) · Biochemistry · doi:10.1021/bi9818772 · Cited by 290 · see citing works

HO ₂ •: The Forgotten Radical

de Grey, A. D. N. J. (2002) · DNA and Cell Biology · doi:10.1089/104454902753759672 · Cited by 279 · see citing works

Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps

von Köckritz‐Blickwede, M., & Nizet, V. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0481-0 · Cited by 270 · see citing works

CFTR Expression in Human Neutrophils and the Phagolysosomal Chlorination Defect in Cystic Fibrosis

Painter, R. G., Valentine, V. G., Lanson, N. A., et al. (2006) · Biochemistry · doi:10.1021/bi060490t · Cited by 269 · see citing works

Regulation and termination of NADPH oxidase activity

DeCoursey, T. E., & Ligeti, E. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5177-1 · Cited by 268 · see citing works

Antibody Catalysis of the Oxidation of Water

Wentworth, P., Jones, L. H., Wentworth, A. D., et al. (2001) · Science · doi:10.1126/science.1062722 · Cited by 267 · see citing works

Quantitative and temporal characterization of the extracellular H2O2 pool generated by human neutrophils.

Test, S. T., & Weiss, S. J. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43674-x · Cited by 266 · see citing works

Singlet oxygen production by biological systems

Kanofsky, J. R. (1989) · Chemico-Biological Interactions · doi:10.1016/0009-2797(89)90059-8 · Cited by 259 · see citing works

Intracellular singlet oxygen generation by phagocytosing neutrophils in response to particles coated with a chemical trap.

Steinbeck, M. J., Khan, A. U., & Karnovsky, M. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42228-4 · Cited by 258 · see citing works

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

Ramsey, I. S., Ruchti, E., Kaczmarek, J. S., & Clapham, D. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902761106 · Cited by 255 · see citing works

Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils.

Thomas, E. L., Grisham, M. B., & Jefferson, M. M. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110992 · Cited by 251 · see citing works

Consequences of Total and Subtotal Myeloperoxidase Deficiency: Risk or Benefit ?

Kutter, D., Devaquet, P., Vanderstocken, G., Paulus, J., Marchal, V., & Gothot, A. (2000) · Acta Haematologica · doi:10.1159/000041062 · Cited by 250 · see citing works

A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production

Chen, X., Lee, K.-A., Ha, E.-M., Lee, K. M., Seo, Y. Y., Choi, H. K., Kim, H. N., Kim, M. J., Cho, C.-S., Lee, S. Y., et al. (2011) · Chemical Communications · doi:10.1039/c1cc10589b · Cited by 246 · see citing works

Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases

Poole, L. B. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.006 · Cited by 246 · see citing works

Myeloperoxidase Deficiency

Parry, M. F., ROOT, R. K., METCALF, J. A., DELANEY, K. K., KAPLOW, L. S., & RICHAR, W. J. (1981) · Annals of Internal Medicine · doi:10.7326/0003-4819-95-3-293 · Cited by 243 · see citing works

Interaction of myeloperoxidase with peroxynitrite

Floris, R., Piersma, S. R., Guang, Y. A. N. G., Jones, P. M., & Wever, R. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18091.x · Cited by 237 · see citing works

Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes.

Ramos, C. L., Pou, S., Britigan, B. E., Cohen, M. S., & Rosen, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42443-x · Cited by 230 · see citing works

Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols

Hazen, S. L., Hsu, F. F., Duffin, K., & Heinecke, J. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23080 · Cited by 221 · see citing works

Nitroxidative, Nitrosative, and Nitrative Stress:  Kinetic Predictions of Reactive Nitrogen Species Chemistry Under Biological Conditions

Lancaster, J. R. (2006) · Chemical Research in Toxicology · doi:10.1021/tx060061w · Cited by 219 · see citing works

Reactive oxygen species in phagocytic leukocytes

Robinson, J. M. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0461-4 · Cited by 216 · see citing works

Intraphagosomal Peroxynitrite as a Macrophage-derived Cytotoxin against Internalized Trypanosoma cruzi

Álvarez, M. N., Peluffo, G., Piacenza, L., & Radí, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.167247 · Cited by 216 · see citing works

Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Staphylococcus aureus by neutrophils

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1996) · Infection and Immunity · doi:10.1128/iai.64.9.3512-3517.1996 · Cited by 213 · see citing works

Free Hydroxyl Radicals are Formed on Reaction Between the Neutrophil-Derived Species Superoxide Anion and Hypochlorous Acid

Candeias, L. P., Patel, K. B., Stratford, M. R. L., & Wardman, P. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80394-a · Cited by 212 · see citing works

Investigating antibody-catalyzed ozone generation by human neutrophils

BABIOR, B. M., Takeuchi, C., Ruedi, J. M., Gutierrez, A., & Wentworth, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530251100 · Cited by 211 · see citing works

Antimicrobial polypeptides of human neutrophils

Lehrer, R., & Ganz, T. (1990) · Blood · doi:10.1182/blood.v76.11.2169.bloodjournal76112169 · Cited by 206 · see citing works

Reactions involving singlet oxygen and the superoxide anion

Koppenol, W. H. (1976) · Nature · doi:10.1038/262420a0 · Cited by 202 · see citing works

Chlorination of Bacterial and Neutrophil Proteins during Phagocytosis and Killing of Staphylococcus aureus

Chapman, A., Hampton, M. B., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106134200 · Cited by 200 · see citing works

Intracellular generation of superoxide by the phagocyte NADPH oxidase: How, where, and what for?

Bylund, J., Brown, K. L., Movitz, C., Dahlgren, C., & Karlsson, A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.016 · Cited by 196 · see citing works

Isolation procedure and some properties of myeloperoxidase from human leucocytes

Bakkenist, A. R. J., Wever, R., Vulsma, T., Plat, H., & GELDER, B. F. V. (1978) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(78)90101-8 · Cited by 193 · see citing works

General mechanism for the bacterial toxicity of hypochlorous acid: abolition of ATP production

Barrette, W. C., Hannum, D. M., Wheeler, W. D., et al. (1989) · Biochemistry · doi:10.1021/bi00449a032 · Cited by 192 · see citing works

Effects of oxygen tension and pH on the respiratory burst of human neutrophils

Gabig, T., Bearman, S., & Babior, B. (1979) · Blood · doi:10.1182/blood.v53.6.1133.1133 · Cited by 190 · see citing works

VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification

Chemaly, A. E., Okochi, Y., Sasaki, M., Arnaudeau, S., Okamura, Y., & Demaurex, N. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091837 · Cited by 189 · see citing works

Determinants of the Phagosomal pH in Neutrophils

Jankowski, A. W., Scott, C. C., & Grinstein, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110059200 · Cited by 181 · see citing works

Gene Expression Profiling Provides Insight into the Pathophysiology of Chronic Granulomatous Disease

Kobayashi, S. D., Voyich, J. M., Braughton, K. R., Whitney, A. R., Nauseef, W. M., Malech, H. L., & DeLeo, F. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.636 · Cited by 177 · see citing works

Human Neutrophils Employ the Myeloperoxidase-Hydrogen Peroxide-Chloride System to Oxidize α-Amino Acids to a Family of Reactive Aldehydes

Hazen, S. L., d'Avignon, A., Anderson, M. M., Hsu, F., & Heinecke, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.4997 · Cited by 174 · see citing works

Human Neutrophils Kill Streptococcus pneumoniae via Serine Proteases

Standish, A. J., & Weiser, J. N. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900688 · Cited by 174 · see citing works

2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation

Tiden, A. K., Sjögren, T., Svensson, M., Bernlind, A., Senthilmohan, R., Auchère, F., Norman, H. L., Markgren, P.-O., Gustavsson, S., Schmidt, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.266981 · Cited by 163 · see citing works

NEUTROPHIL DYSFUNCTION, CHRONIC GRANULOMATOUS DISEASE, AND NON-SPHEROCYTIC HÆMOLYTIC ANÆMIA CAUSED BY COMPLETE DEFICIENCY OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE

Gray, G. R., Stamatoyannopoulos, G., Naiman, S. C., Kliman, M. R., Klebanoff, S. J., Austin, T., Yoshida, A., & Robinson, G. C. F. (1973) · The Lancet · doi:10.1016/s0140-6736(73)92350-7 · Cited by 162 · see citing works

Dual role of phagocytic NADPH oxidase in bacterial killing

Rada, B., Geiszt, M., Káldi, K., Tímár, C. I., & Ligeti, E. (2004) · Blood · doi:10.1182/blood-2004-03-1005 · Cited by 161 · see citing works

Phagolysosomal pH of human neutrophils

Čech, P., & Lehrer, R. (1984) · Blood · doi:10.1182/blood.v63.1.88.88 · Cited by 156 · see citing works

Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils

Rosen, H., Klebanoff, S. J., Wang, Y., Brot, N., Heinecke, J. W., & Fu, X. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909464106 · Cited by 154 · see citing works

Generation of nitrogen-chlorine oxidants by human phagocytes.

Test, S. T., Lampert, M. B., Ossanna, P. J., Thoene, J. G., & Weiss, S. J. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111544 · Cited by 154 · see citing works

Production of the superoxide adduct of myeloperoxidase (compound III) by stimulated human neutrophils and its reactivity with hydrogen peroxide and chloride

Winterbourn, C. C., Garcia, R. C., & Segal, A. W. (1985) · Biochemical Journal · doi:10.1042/bj2280583 · Cited by 153 · see citing works

Charge compensation during the phagocyte respiratory burst

Murphy, R., & DeCoursey, T. E. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.01.005 · Cited by 151 · see citing works

Superoxide Converts Indigo Carmine to Isatin Sulfonic Acid

Kettle, A. J., Clark, B. M., & Winterbourn, C. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400334200 · Cited by 142 · see citing works

Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus

Aratani, Y., Kura, F., Watanabe, H., Akagawa, H., Takano, Y., Suzuki, K. T., Dinauer, M. C., Maeda, N., & Koyama, H. (2002) · Medical Mycology · doi:10.1080/mmy.40.6.557.563 · Cited by 142 · see citing works

Role of superoxide dismutase and catalase as determinants of pathogenicity of Nocardia asteroides: importance in resistance to microbicidal activities of human polymorphonuclear neutrophils

Beaman, B. L., Black, C. M., Doughty, F. A., & Beaman, L. (1985) · Infection and Immunity · doi:10.1128/iai.47.1.135-141.1985 · Cited by 137 · see citing works

Spectral and Kinetic Studies on the Formation of Myeloperoxidase Compounds I and II: Roles of Hydrogen Peroxide and Superoxide

Marquez‐Curtis, L. A., Huang, J., & Dunford, H. B. (1994) · Biochemistry · doi:10.1021/bi00172a022 · Cited by 135 · see citing works

Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst.

Borregaard, N., Schwartz, J. H., & Tauber, A. I. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111442 · Cited by 135 · see citing works

Urate as a Physiological Substrate for Myeloperoxidase

Meotti, F. C., Jameson, G. N. L., Turner, R., Harwood, D. T., Stockwell, S., Rees, M. D., Thomas, S. R., & Kettle, A. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.172460 · Cited by 133 · see citing works

Human Neutrophils Employ Myeloperoxidase To Convert α-Amino Acids to a Battery of Reactive Aldehydes: A Pathway for Aldehyde Generation at Sites of Inflammation

Hazen, S. L., Hsu, F., d'Avignon, A., & Heinecke, J. W. (1998) · Biochemistry · doi:10.1021/bi972449j · Cited by 133 · see citing works

Oxidation of intracellular glutathione after exposure of human red blood cells to hypochlorous acid

Vissers, M. C. M., & Winterbourn, C. C. (1995) · Biochemical Journal · doi:10.1042/bj3070057 · Cited by 131 · see citing works

Myeloperoxidase-catalyzed incorporation of amines into proteins: role of hypochlorous acid and dichloramines

Thomas, E. L., Jefferson, M. M., & Grisham, M. B. (1982) · Biochemistry · doi:10.1021/bi00267a040 · Cited by 128 · see citing works

CdSe-ZnS Quantum Dots for Selective and Sensitive Detection and Quantification of Hypochlorite

Yan, Y., Wang, S., Liu, Z., et al. (2010) · Analytical Chemistry · doi:10.1021/ac101929q · Cited by 128 · see citing works

Chlorination of taurine by myeloperoxidase. Kinetic evidence for an enzyme-bound intermediate.

Marquez‐Curtis, L. A., & Dunford, H. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37143-0 · Cited by 126 · see citing works

What really happens in the neutrophil phagosome?

Hurst, J. K. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.008 · Cited by 124 · see citing works

Lysine Residues Direct the Chlorination of Tyrosines in YXXK Motifs of Apolipoprotein A-I When Hypochlorous Acid Oxidizes High Density Lipoprotein

Bergt, C., Fu, X., Saifee, N. H., Kao, J. L.-F., & Heinecke, J. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309046200 · Cited by 123 · see citing works

[41] Cytotoxicity of chloramines

Thomas, E. L., Grisham, M. B., & Jefferson, M. M. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(86)32043-3 · Cited by 123 · see citing works

Phorbol myristate acetate-induced NADPH oxidase activity in human neutrophils: only half the story has been told

Lundqvist, H., Foilin, P., Khalfan, L., & Dahlgren, C. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.2.270 · Cited by 121 · see citing works

Radical–radical reactions of superoxide: A potential route to toxicity

Winterbourn, C. C., & Kettle, A. J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00810-6 · Cited by 118 · see citing works

Differential Host Susceptibility to Pulmonary Infections with Bacteria and Fungi in Mice Deficient in Myeloperoxidase

Aratani, Y., Kura, F., Watanabe, H., Akagawa, H., Takano, Y., Suzuki, K. T., Maeda, N., & Koyama, H. (2000) · The Journal of Infectious Diseases · doi:10.1086/315843 · Cited by 116 · see citing works

Superoxide production by polymorphonuclear leukocytes

Briggs, R. T., Robinson, J. M., Karnovsky, M. J., & Karnovsky, M. J. (1986) · Histochemistry and Cell Biology · doi:10.1007/bf00482965 · Cited by 116 · see citing works

Redox properties of the couples compound I/compound II and compound II/native enzyme of human myeloperoxidase

Furtmüller, P. G., Arnhold, J., Jantschko, W., Pichler, H., & Obinger, C. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)03075-9 · Cited by 109 · see citing works

Generation of Intramolecular and Intermolecular Sulfenamides, Sulfinamides, and Sulfonamides by Hypochlorous Acid: A Potential Pathway for Oxidative Cross-Linking of Low-Density Lipoprotein by Myeloperoxidase

Fu, X., Mueller, D. M., & Heinecke, J. W. (2001) · Biochemistry · doi:10.1021/bi015777z · Cited by 107 · see citing works

Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte

Reeves, E. P., Nagl, M., Godovac‐Zimmermann, J., & Segal, A. W. (2003) · Journal of Medical Microbiology · doi:10.1099/jmm.0.05181-0 · Cited by 105 · see citing works

Reactive Oxygen Species Are Partially Involved in the Bacteriocidal Action of Hypochlorous Acid

Dukan, S., Belkin, S., & Touati, D. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1265 · Cited by 104 · see citing works

Myeloperoxidase Deficiency

Nauseef, W. M. (1988) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30634-8 · Cited by 103 · see citing works

Redox properties of the couple compound I/native enzyme of myeloperoxidase and eosinophil peroxidase

Arnhold, J., Furtmüller, P. G., Regelsberger, G., & Obinger, C. (2001) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02449.x · Cited by 101 · see citing works

The NADPH oxidase complex of phagocytic leukocytes: a biochemical and cytochemical view

Robinson, J. M., & Badwey, J. A. (1995) · Histochemistry and Cell Biology · doi:10.1007/bf01454021 · Cited by 101 · see citing works

Reactions of Superoxide with Myeloperoxidase

Kettle, A. J., Anderson, R. F., Hampton, M. B., & Winterbourn, C. C. (2007) · Biochemistry · doi:10.1021/bi602587k · Cited by 99 · see citing works

Kinetics of oxygen consumption by phagocytosing human neutrophils

Segal, A. W., & Coade, S. B. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)90749-0 · Cited by 99 · see citing works

Comparative study of the metabolic and bactericidal characteristics of severely glucose-6-phosphate dehydrogenase-deficient polymorphonuclear leukocytes and leukocytes from children with chronic granulomatous disease.

Baehner, R., Rb, J., & Nathan, D. (1972) · PubMed · Cited by 99 · see citing works

Voltage-Gated Proton Channels Find Their Dream Job Managing the Respiratory Burst in Phagocytes

DeCoursey, T. E. (2010) · Physiology · doi:10.1152/physiol.00039.2009 · Cited by 98 · see citing works

Superoxide Dismutase from Mycobacterium tuberculosis

Kusunose, E., Ichihara, K., Yojiro, N. O. D. A., et al. (1976) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a131407 · Cited by 97 · see citing works

Regulation of Glycogen Metabolism in Polymorphonuclear Leukocytes

Stossel, T. P., Murad, F., Mason, R. J., et al. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62682-1 · Cited by 95 · see citing works

A Kinetic Analysis of the Catalase Activity of Myeloperoxidase

Kettle, A. J., & Winterbourn, C. C. (2001) · Biochemistry · doi:10.1021/bi010940b · Cited by 94 · see citing works

CFTR-mediated halide transport in phagosomes of human neutrophils

Painter, R. G., Marrero, L., Lombard, G. A., Valentine, V. G., Nauseef, W. M., & Wang, G. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1009655 · Cited by 91 · see citing works

Chlorine transfer between glycine, taurine, and histamine: reaction rates and impact on cellular reactivity

Peskin, A. V., Midwinter, R. G., Harwood, D. T., & Winterbourn, C. C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.010 · Cited by 90 · see citing works

The Antibacterial Activity of Human Neutrophils and Eosinophils Requires Proton Channels but Not BK Channels

Femling, J., Cherny, V. V., Morgan, D., Rada, B., Volk, A. P. D., Czirják, G., Enyedi, P., England, S. K., Moreland, J. G., Ligeti, E., et al. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609504 · Cited by 90 · see citing works

Intraphagosomal Chlorination Dynamics and Yields Determined Using Unique Fluorescent Bacterial Mimics

Jiang, Q., Griffin, D. A., Barofsky, D. F., & Hurst, J. K. (1997) · Chemical Research in Toxicology · doi:10.1021/tx9700984 · Cited by 89 · see citing works

Chronic Granulomatous Disease; fundamental stages in our understanding of CGD

Assari, T. (2006) · Medical Immunology · doi:10.1186/1476-9433-5-4 · Cited by 87 · see citing works

Neutrophil Bleaching of GFP-Expressing Staphylococci: Probing the Intraphagosomal Fate of Individual Bacteria

Schwartz, J., Leidal, K. G., Femling, J., Weiss, J. P., & Nauseef, W. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804110 · Cited by 86 · see citing works

Relative Chlorinating, Nitrating, and Oxidizing Capabilities of Neutrophils Determined with Phagocytosable Probes

Jiang, Q., & Hurst, J. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32767 · Cited by 84 · see citing works

Superoxide-dependent Oxidation of Melatonin by Myeloperoxidase

Ximenes, V. F., Silva, S. D. O., Rodrigues, M. R., Catalani, L. H., Maghzal, G. J., Kettle, A. J., & Campa, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506384200 · Cited by 83 · see citing works

Nox enzymes in immune cells

Nauseef, W. M. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0117-4 · Cited by 82 · see citing works

Superoxide-dependent hydroxylation by myeloperoxidase.

Kettle, A. J., & Winterbourn, C. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32533-4 · Cited by 82 · see citing works

Chloride movements in human neutrophils. Diffusion, exchange, and active transport.

Simchowitz, L., & Weer, P. D. (1986) · The Journal of General Physiology · doi:10.1085/jgp.88.2.167 · Cited by 81 · see citing works

Oxidant-mediated phosphatidylserine exposure and macrophage uptake of activated neutrophils: possible impairment in chronic granulomatous disease

Hampton, M. B., Vissers, M. C. M., Keenan, J. I., & Winterbourn, C. C. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.5.775 · Cited by 81 · see citing works

Invited Review: Cell Damage in Inflammatory and Infectious Sites Might Involve A Coordinated “Cross-Talk” Among Oxidants, Microbial Haemolysins and Ampiphiles, Cationic Proteins, Phospholipases, Fatty Acids, Proteinases and Cytokines (An Overview)

Ginsburg, I., & Kohen, R. (1995) · Free Radical Research · doi:10.3109/10715769509150323 · Cited by 75 · see citing works

Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice

Brovkovych, V. M., Gao, X.-P., Ong, E., Brovkovych, S. D., Brennan, M., Su, X., Hazen, S. L., Malik, A. B., & Skidgel, R. A. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00450.2007 · Cited by 74 · see citing works

Neutrophils autoinactivate secretory products by myeloperoxidase- catalyzed oxidation

Clark, R. A., & Borregaard, N. (1985) · Blood · doi:10.1182/blood.v65.2.375.375 · Cited by 74 · see citing works

Oxygen, oxysterols, ouabain, and ozone: a cautionary tale

Smith, L. L. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.024 · Cited by 72 · see citing works

Myeloperoxidase-dependent oxidative inactivation of neutrophil neutral proteinases and microbicidal enzymes

Vissers, M. C. M., & Winterbourn, C. C. (1987) · Biochemical Journal · doi:10.1042/bj2450277 · Cited by 72 · see citing works

Myeloperoxidase-Dependent Generation of a Tyrosine Peroxide by Neutrophils

Winterbourn, C. C., Pichorner, H., & Kettle, A. J. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.9773 · Cited by 71 · see citing works

Chlorine covers on living bacteria: the initial step in antimicrobial action of active chlorine compounds

Gottardi, W., & Nagl, M. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki054 · Cited by 70 · see citing works

Physiological production of singlet molecular oxygen in the myeloperoxidase‐H2O2‐chloride system

Kiryu, C., Makiuchi, M., Miyazaki, J., FUJINAGA, T., & Kakinuma, K. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01700-1 · Cited by 68 · see citing works

Exocytosis by Neutrophils

Baggiolini, M., & Dewald, B. (1984) · Springer eBooks · doi:10.1007/978-1-4757-4862-8_8 · Cited by 65 · see citing works

Early changes of hexose monophosphate pathway activity and of NADPH oxidation in phagocytizing leucocytes

Zatti, M., & Rossi, F. (1965) · Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation · doi:10.1016/s0926-6593(65)80213-2 · Cited by 64 · see citing works

Chloride ion efflux regulates adherence, spreading, and respiratory burst of neutrophils stimulated by tumor necrosis factor-alpha (TNF) on biologic surfaces.

Menegazzi, R., Busetto, S., Dri, P., Cramer, R., & Patriarca, P. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.2.511 · Cited by 64 · see citing works

NADPH oxidase is functionally assembled in specific granules during activation of human neutrophils

Vaissière, C., Cabec, V. L., & Maridonneau‐Parini, I. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.5.629 · Cited by 63 · see citing works

Molecular and Functional Characterization of Hv1 Proton Channel in Human Granulocytes

Petheö, G. L., Orient, A., Baráth, M., Kovács, I. A., Réthi, B., Lányi, Á., Rajki, A., Rajnavölgyi, É., & Geiszt, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014081 · Cited by 63 · see citing works

Electron transfer in the superoxide-generating NADPH oxidase complex reconstituted in vitro

Koshkin, V., Lotan, O., & Pick, E. (1997) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(96)00154-5 · Cited by 61 · see citing works

Role of NADPH Oxidase versus Neutrophil Proteases in Antimicrobial Host Defense

Vethanayagam, R. R., Almyroudis, N. G., Grimm, M. J., Lewandowski, D. C., Pham, C. T. N., Blackwell, T. S., Petraitienė, R., Petraitis, V., Walsh, T. J., Urban, C. F., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028149 · Cited by 59 · see citing works

Myeloperoxidase Selectively Binds and Selectively Kills Microbes

Allen, R. C., & Stephens, J. T. (2010) · Infection and Immunity · doi:10.1128/iai.00910-09 · Cited by 59 · see citing works

A pulse radiolysis investigation of the reactions of myeloperoxidase with superoxide and hydrogen peroxide

Kettle, A. J., Sangster, D. F., Gebicki, J. M., & Winterbourn, C. C. (1988) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(88)90297-x · Cited by 58 · see citing works

Oxidation of Methionine to Dehydromethionine by Reactive Halogen Species Generated by Neutrophils

Peskin, A. V., Turner, R., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2009) · Biochemistry · doi:10.1021/bi901266w · Cited by 58 · see citing works

Enhanced Killing of Myeloperoxidase-Coated Bacteria in the Myeloperoxidase-H2O2-C1- System

Selvaraj, R. J., Zgliczyński, J. M., Paul, B. B., & Sbarra, A. J. (1978) · The Journal of Infectious Diseases · doi:10.1093/infdis/137.4.481 · Cited by 57 · see citing works

Hypobromous acid and bromamine production by neutrophils and modulation by superoxide

Chapman, A., Skaff, O., Senthilmohan, R., Kettle, A. J., & Davies, M. J. (2008) · Biochemical Journal · doi:10.1042/bj20071563 · Cited by 57 · see citing works

Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione

Ximenes, V. F., Maghzal, G. J., Turner, R., Kato, Y., Winterbourn, C. C., & Kettle, A. J. (2009) · Biochemical Journal · doi:10.1042/bj20090776 · Cited by 54 · see citing works

Superoxide-mediated Formation of Tyrosine Hydroperoxides and Methionine Sulfoxide in Peptides through Radical Addition and Intramolecular Oxygen Transfer

Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809396200 · Cited by 53 · see citing works

Direct Measurement of Free Chloride Concentrations in the Phagolysosomes of Human Neutrophils

Painter, R. G., & Wang, G. (2006) · Analytical Chemistry · doi:10.1021/ac0521706 · Cited by 53 · see citing works

Pathways for the Decay of Organic Dichloramines and Liberation of Antimicrobial Chloramine Gases

Coker, M. S. A., Hu, W., Senthilmohan, S. T., et al. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800232v · Cited by 49 · see citing works

Cytochemical demonstration of hydrogen peroxide in polymorphonuclear leukocyte phagosomes

Briggs, R., Karnovsky, M. L., & Mj, K. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.64.1.254 · Cited by 49 · see citing works

Oxidation of Clozapine and Ascorbate by Myeloperoxidase

Hsuanyu, Y., & Dunford, H. B. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1328 · Cited by 49 · see citing works

Superoxide enhances hypochlorous acid production by stimulated human neutrophils

Kettle, A. J., & Winterbourn, C. C. (1990) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(90)90146-5 · Cited by 48 · see citing works

Green Fluorescent Protein-ExpressingEscherichia colias a Selective Probe for HOCl Generation within Neutrophils

Palazzolo, A. M., Suquet, C., Konkel, M. E., & Hurst, J. K. (2005) · Biochemistry · doi:10.1021/bi047342s · Cited by 48 · see citing works

Electrophysiology of Reactive Oxygen Production in Signaling Endosomes

Lamb, F. S., Moreland, J. G., & Miller, F. J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2448 · Cited by 47 · see citing works

Kinetic analysis of phagosomal production of reactive oxygen species

Tlili, A., Dupré‐Crochet, S., Erard, M., & Nüße, O. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.024 · Cited by 46 · see citing works

Rat, mouse and human neutrophils stimulated by a variety of activating agents produce much less nitrite than rodent macrophages.

Padgett, E. L., & Pruett, S. B. (1995) · PubMed · Cited by 43 · see citing works

Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway

Tomono, S., Miyoshi, N., Shiokawa, H., Iwabuchi, T., Aratani, Y., Higashi, T., Nukaya, H., & Ohshima, H. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m006775 · Cited by 43 · see citing works

Interrogation of Heme Pocket Environment of Mammalian Peroxidases with Diatomic Ligands

Abu‐Soud, H. M., & Hazen, S. L. (2001) · Biochemistry · doi:10.1021/bi010478v · Cited by 42 · see citing works

Thymine hydroperoxide as a potential source of singlet molecular oxygen in DNA

Prado, F. M., de Oliveira, M. C. B., Miyamoto, S., Martinez, G. R., de Medeiros, M. H. G., Ronsein, G. E., & Mascio, P. D. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.001 · Cited by 41 · see citing works

Role of high-avidity binding of human neutrophil myeloperoxidase in the killing of Actinobacillus actinomycetemcomitans

Miyasaki, K. T., Zambon, J. J., Jones, C. A., & Wilson, M. E. (1987) · Infection and Immunity · doi:10.1128/iai.55.5.1029-1036.1987 · Cited by 40 · see citing works

An Intact Cytoskeleton is Required for Prolonged Respiratory Burst Activity During Neutrophil Phagocytosis

Granfeldt, D., & Dahlgren, C. (2001) · Inflammation · doi:10.1023/a:1011084330283 · Cited by 39 · see citing works

Physiological roles of voltage-gated proton channels in leukocytes

Demaurex, N., & Chemaly, A. E. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.194225 · Cited by 36 · see citing works

Hypochlorous Acid Reacts with the N-Terminal Methionines of Proteins To Give Dehydromethionine, a Potential Biomarker for Neutrophil-Induced Oxidative Stress

Beal, J. L., Foster, S. B., & Ashby, M. T. (2009) · Biochemistry · doi:10.1021/bi901343d · Cited by 36 · see citing works

Phagocyte‐derived reactive oxygen species as suppressors of inflammatory disease

Björkman, L. I., Dahlgren, C., Karlsson, A., Brown, K. L., & Bylund, J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23941 · Cited by 36 · see citing works

Chloride Movements in Human Neutrophils during Phagocytosis: Characterization and Relationship to Granule Release

Busetto, S., Trevisan, E., Decleva, E., Dri, P., & Menegazzi, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4110 · Cited by 35 · see citing works

Electron microscopic study of phagocytosis of Escherichia coli by human polymorphonuclear leukocytes

Rozenberg-Arska, M., Salters, M. E., van Strijp, J. A. G., et al. (1985) · Infection and Immunity · doi:10.1128/iai.50.3.852-859.1985 · Cited by 34 · see citing works

Reconstitution of bactericidal activity in chronic granulomatous disease cells by glucose-oxidase–containing liposomes

Gerber, C. E., Bruchelt, G., Falk, U. B., Kimpfler, A., Hauschild, O., Kuçi, S., Bächi, T., NIETHAMMER, D., & Schubert, R. (2001) · Blood · doi:10.1182/blood.v98.10.3097 · Cited by 32 · see citing works

13 reasons why the brain is susceptible to oxidative stress

Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215 · see citing works

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

Metzler, K. D., Goosmann, C., Lubojemska, A., Zychlinsky, A., & Papayannopoulos, V. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.044 · Cited by 741 · see citing works

Functions of ROS in Macrophages and Antimicrobial Immunity

Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

Nox enzymes and new thinking on reactive oxygen: A double-edged sword revisited

Lambeth, J. D., & Neish, A. S. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104651 · Cited by 495 · see citing works

The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease

Davies, M. J., & Hawkins, C. L. (2020) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2020.8030 · Cited by 332 · see citing works

The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens

Ulfig, A., & Leichert, L. I. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03591-y · Cited by 239 · see citing works

Mitochondria-derived vesicles deliver antimicrobial reactive oxygen species to control phagosome-localized staphylococcus aureus

Abuaita, B. H., Schultz, T. L., & O’Riordan, M. X. (2018) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2018.10.005 · Cited by 223 · see citing works

Vitamin C: a novel regulator of neutrophil extracellular trap formation.

Mohammed, B., Fisher, B., Kraskauskas, D., Farkas, D., Brophy, D., Fowler, A., & Natarajan, R. (2013) · Nutrients · doi:10.3390/nu5083131 · Cited by 187 · see citing works

The phagocyte NOX2 NADPH oxidase in microbial killing and cell signaling

Nauseef, W. M. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.05.006 · Cited by 188 · see citing works

Detection of superoxide anion and hydrogen peroxide production by cellular NADPH oxidases

Nauseef, W. M. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.040 · Cited by 180 · see citing works

Cell death by phagocytosis

Brown, G. C. (2024) · Nature Reviews Immunology · doi:10.1038/s41577-023-00921-6 · Cited by 129 · see citing works

Myeloperoxidase: Mechanisms, Reactions and Inhibition as a Therapeutic Strategy in Inflammatory Diseases

Davies, M. J. (2021) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2020.107685 · Cited by 119 · see citing works

Topical hypochlorite ameliorates NF-κB–mediated skin diseases in mice

Leung, T. H., Zhang, L. F., Wang, J., Ning, S., Knox, S. J., & Kim, S. K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70895 · Cited by 107 · see citing works

Myeloperoxidase Acts as a Source of Free Iron During Steady-State Catalysis by a Feedback Inhibitory Pathway

Maitra, D., Shaeib, F., Abdulhamid, I., Abdulridha, R. M., Saed, G. M., Diamond, M. P., Pennathur, S., & Abu-Soud, H. M. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.009 · Cited by 64 · see citing works

Cytosolic Fe-superoxide dismutase safeguards <i>Trypanosoma cruzi</i> from macrophage-derived superoxide radical

Martínez, A., Prolo, C., Estrada, D., Rios, N., Alvarez, M. N., Piñeyro, M. D., Robello, C., Radi, R., & Piacenza, L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821487116 · Cited by 41 · see citing works

Topical Hypochlorous Acid (HOCl) as a Potential Treatment of Pruritus

Pelgrift, R. Y., & Friedman, A. J. (2013) · Current Dermatology Reports · doi:10.1007/s13671-013-0052-z · Cited by 24 · see citing works

Serotonin as a Putative Scavenger of Hypohalous Acid in the Brain

Kalogiannis, M., Delikatny, E. J., & Jeitner, T. M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.012 · Cited by 19 · see citing works

Evaluation of systemic levels of neutrophilic enzymes in patients with hypertension and chronic periodontitis

Türkoğlu, O., Barış, N., Tervahartiala, T., Şenarslan, Ö., Sorsa, T., & Atilla, G. (2014) · Journal of Periodontology · doi:10.1902/jop.2013.130346 · Cited by 17 · see citing works

The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes.

Joiner, K. A., Ganz, T., Albert, J. P., & Rotrosen, D. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.2771 · Cited by 117 · see citing works

A DNA-based fluorescent reporter maps HOCl production in the maturing phagosome

Thekkan, S., Jani, M. S., Cui, C., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0176-3 · Cited by 80 · see citing works

Fusion of Azurophil Granules with Phagosomes and Activation of the Tyrosine Kinase Hck Are Specifically Inhibited During Phagocytosis of Mycobacteria by Human Neutrophils

N’Diaye, E.-N., Darzacq, X., Astarie‐Dequeker, C., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4983 · Cited by 90 · see citing works

Membrane Dynamics and Organization of the Phagocyte NADPH Oxidase in PLB-985 Cells

Joly, J., Hudik, E., Lécart, S., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.608600 · Cited by 17 · see citing works

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

Ramsey, I. S., Ruchti, E., Kaczmarek, J. S., & Clapham, D. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902761106 · Cited by 255 · see citing works