The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Binding Interactions between Long Noncoding RNA HOTAIR and PRC2 Proteins
Open accessAbstract
Long noncoding RNAs (lncRNAs) play a key role in the epigenetic regulation of cells. Many of these lncRNAs function by interacting with histone repressive proteins of the Polycomb group (PcG) family, recruiting them to gene loci to facilitate silencing. Although there are now many RNAs known to interact with the PRC2 complex, little is known about the details of the molecular interactions. Here, we show that the PcG protein heterodimer EZH2-EED is necessary and sufficient for binding to the lncRNA HOTAIR. We also show that protein recognition occurs within a folded 89-mer domain of HOTAIR. This 89-mer represents a minimal binding motif, as further deletion of nucleotides results in substantial loss of affinity for PRC2. These findings provide molecular insights into an important system involved in epigenetic regulation.
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Cites
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Batista, P. J., & Chang, H. Y. (2013) · Cell · doi:10.1016/j.cell.2013.02.012 · Cited by 2,531
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Functions of lncRNA HOTAIR in lung cancer
Loewen, G., Jayawickramarajah, J., Zhuo, Y., & Shan, B. (2014) · Journal of Hematology & Oncology · doi:10.1186/s13045-014-0090-4 · Cited by 454
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Wang, Z., Zhang, X.-J., Ji, Y.-X., Zhang, P., Deng, K.-Q., Gong, J., Ren, S., Wang, X., Chen, I., Wang, H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4179 · Cited by 386
Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications
Kapusta, A., & Feschotte, C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.08.004 · Cited by 295
Ren, Y., Jia, H.-H., Xu, Y.-Q., Zhou, X., Zhao, X.-H., Wang, Y.-F., Song, X., Zhu, Z.-Y., Sun, T., Dou, Y., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0758-4 · Cited by 217
Metadata
- Authors
- Wu, L., Murat, P., Matak-Vinkovic, D., Murrell, A., & Balasubramanian, S.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-12-17
- Volume
- 52
- Issue
- 52
- Pages
- 9519-9527
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2028434128
- Cited by
- 184
- References
- 3
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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