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Cited by 772Cancer, Lipids, and MetabolismLipid metabolism and biosynthesisSphingolipid Metabolism and Signaling

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

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Baenke, Franziska, Peck, Barrie, Miess, Heike, Schulze, Almut·2013·Disease Models & Mechanisms
DOI 10.1242/dmm.011338PMC PMC3820259
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Abstract

An increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells. However, the contribution of lipids to cellular transformation, tumour development and tumour progression, as well as their potential role in facilitating the spread of cancerous cells to secondary sites, are not yet fully understood. In this article, we review the recent findings that support the importance of lipid synthesis and metabolism in tumorigenesis. Specifically, we explore the role of aberrant lipid biosynthesis in cancer cell migration and invasion, and in the induction of tumour angiogenesis. These processes are crucial for the dissemination of tumour cells and formation of metastases, which constitute the main cause of cancer mortality.

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  • Changes in the polyunsaturation of membrane lipids facilitate the invasive and motile cancer phenotype.

    “While changes in the polyunsaturation of membrane lipids facilitate the invasive and motile cancer phenotype (9), cancer cells become susceptible to lipoxygenase/Fenton reaction–induced lipid-ROS damage and are dependent on the activity of GPX4 to maintain viability (6).”

    From Secreted Apoe rewires melanoma cell state vulnerability to ferroptosis (2024) · cites this paper as [9]

    The ‘Lipid metabolism and hypoxia’ section says changes in lipid desaturation could affect membrane fluidity and contribute to cancer cell migration. It does not specifically identify polyunsaturation of membrane lipids or establish that those changes facilitate both invasion and motility; the ‘Cancer cell migration’ section says the effect of global lipid-composition changes on migration is less clear. Page numbers were not available in our copy. (LLM, conf=0.85)

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Authors
Baenke, F., Peck, B., Miess, H., & Schulze, A.
Affiliations
Cancer Research UK (GB)
Corresponding author
Schulze, Almut
ORCID
Venue
Disease Models & Mechanisms
Publisher
The Company of Biologists
Published
2013-11-01
Volume
6
Issue
6
Pages
1353-1363
ISSN
  • 1754-8403 (ISSN-L)
  • 1754-8411
DOI
10.1242/dmm.011338
PMC
PMC3820259
OpenAlex
W2138110344
Cited by
772
References
13
Citations by year
2026: 27 · 2025: 34 · 2024: 58 · 2023: 53 · 2022: 65 · 2021: 101 · 2020: 94 · 2019: 82 · 2018: 81 · 2017: 64 · 2016: 59 · 2015: 41 · 2014: 11 · 2013: 1
FWCI
3.09
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Disease Models & Mechanisms (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Cancer Research UK
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords
lipogenesis, cancer metabolism, carcinogenesis, tumor progression, tumor cell migration, tumor invasion, tumor angiogenesis, metastasis, lipid metabolism, cell transformation
MeSH terms
Autophagy, Cell Movement, Humans, Lipids, Neoplasms, Neovascularization, Pathologic, Protein Processing, Post-Translational, Cell Hypoxia, Tumor Microenvironment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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