The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Dendrimers: Novel Polymeric Nanoarchitectures for Solubility Enhancement
Abstract
Poor solubility and hydrophobicity of drugs/bioactives limit their possible applications in drug delivery and formulation development. Apart from conventional methods of solubility enhancement, there are some novel methods which can be used in solubilization. Dendrimers represent a novel type of polymeric material that has generated much interest in many diverse areas due to their unique structure and properties. Dendrimer-mediated solubility enhancement mainly depends on factors such as generation size, dendrimer concentration, pH, core, temperature, and terminal functionality. Added advantage in solubilization can be achieved considering these factors. Available literature suggests that ionic interaction, hydrogen bonding, and hydrophobic interactions are the possible mechanisms by which a dendrimer exerts its solubilizing property. This review presents various mechanisms and reports relating to solubility enhancement using dendrimers. Also, micellar behavior and future possibilities in relation to solubilization via dendrimers are included.
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Cites
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A New Class of Polymers: Starburst-Dendritic Macromolecules
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Self-citation
Cited by
Dendrimers Derived from 1 → 3 Branching Motifs
Newkome, G. R., & Shreiner, C. (2010) · Chemical Reviews · doi:10.1021/cr900341m · Cited by 347
New frontiers in nanotechnology for cancer treatment
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Recent advances of discrete coordination complexes and coordination polymers in drug delivery
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Targeting cancer cells with biotin–dendrimer conjugates
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Metadata
- Authors
- Gupta, U., Agashe, H. B., Asthana, A., & Jain, N. K.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-02-15
- Volume
- 7
- Issue
- 3
- Pages
- 649-658
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2082904634
- Cited by
- 375
- References
- 33
- FWCI
- 25.30
- Type
- journal article
- Language
- en
- Open access
- closed
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