The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Oral Bioavailability of Insulin Contained in Polysaccharide Nanoparticles
Open accessAbstract
The pharmacological activity of insulin-loaded dextran sulfate/chitosan nanoparticles was evaluated following oral dosage in diabetic rats. Nanoparticles were mucoadhesive and negatively charged with a mean size of 500 nm, suitable for uptake within the gastrointestinal tract. Insulin association efficiency was over 70% and was released in a pH-dependent manner under simulated gastrointestinal conditions. Orally delivered nanoparticles lowered basal serum glucose levels in diabetic rats around 35% with 50 and 100 IU/kg doses sustaining hypoglycemia over 24 h. Pharmacological availability was 5.6 and 3.4% for the 50 and 100 IU/kg doses, respectively, a significant increase over 1.6%, determined for oral insulin alone in solution. Confocal microscopic examinations of FITC-labeled insulin nanoparticles showed adhesion to rat intestinal epithelium, and internalization of insulin within the intestinal mucosa. Encapsulation of insulin into dextran sulfate/chitosan nanoparticles was a key factor in the improvement of the bioavailability of its oral delivery over insulin solution.
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Cites
Biodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549
Yin Win, K., & Feng, S.-S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.07.050 · Cited by 1,452
Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305
Is the oral route possible for peptide and protein drug delivery?
Morishita, M., & Peppas, N. A. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.08.005 · Cited by 515
Use of fluorescence imaging to investigate the structure and function of intestinal M cells
BUDA, A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.07.014 · Cited by 59
Cited by
Motornov, M., Roiter, Y., Tokarev, I., & Minko, S. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.10.004 · Cited by 773
Emerging micro- and nanotechnology based synthetic approaches for insulin delivery
Mo, R., Jiang, T., Di, J., Tai, W., & Gu, Z. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60436e · Cited by 386
Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment.
Wong, C. Y., Al-Salami, H., & Dass, C. R. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.003 · Cited by 257
Oral insulin delivery: how far are we?
Fonte, P., Araújo, F., Reis, S., & Sarmento, B. (2013) · Journal of Diabetes Science and Technology · doi:10.1177/193229681300700228 · Cited by 211
Self-citationPotential of Chitosan and its derivatives for controlled drug release applications – A review
Safdar, R., Omar, A. A., Arunagiri, A., Regupathi, I., & Thanabalan, M. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.10.020 · Cited by 147
Metadata
- Authors
- Sarmento, B., Ribeiro, A., Veiga, F., Ferreira, D., & Neufeld, R.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-09-18
- Volume
- 8
- Issue
- 10
- Pages
- 3054-3060
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2053041004
- Cited by
- 260
- References
- 5
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- green
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