The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Diels−Alder Click Cross-Linked Hyaluronic Acid Hydrogels for Tissue Engineering
Open accessAbstract
Hyaluronic acid (HA) is a naturally occurring polymer that holds considerable promise for tissue engineering applications. Current cross-linking chemistries often require a coupling agent, catalyst, or photoinitiator, which may be cytotoxic, or involve a multistep synthesis of functionalized-HA, increasing the complexity of the system. With the goal of designing a simpler one-step, aqueous-based cross-linking system, we synthesized HA hydrogels via Diels-Alder "click" chemistry. Furan-modified HA derivatives were synthesized and cross-linked via dimaleimide poly(ethylene glycol). By controlling the furan to maleimide molar ratio, both the mechanical and degradation properties of the resulting Diels-Alder cross-linked hydrogels can be tuned. Rheological and degradation studies demonstrate that the Diels-Alder click reaction is a suitable cross-linking method for HA. These HA cross-linked hydrogels were shown to be cytocompatible and may represent a promising material for soft tissue engineering.
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Cites
Matrix elasticity directs stem cell lineage specification
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Tornøe, C. W., Christensen, C., & Meldal, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo011148j · Cited by 8,696
Controlled Degradation and Mechanical Behavior of Photopolymerized Hyaluronic Acid Networks
Burdick, J. A., Chung, C., Jia, X., Randolph, M. A., & Langer, R. (2005) · Biomacromolecules · doi:10.1021/bm049508a · Cited by 777
Wang, J.-S., & Matyjaszewski, K. (1995) · Macromolecules · doi:10.1021/ma00126a041 · Cited by 486
Cited by
Soft Materials by Design: Unconventional Polymer Networks Give Extreme Properties
Zhao, X., Chen, X., Yuk, H., Lin, S., Liu, X., & Parada, G. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01088 · Cited by 1,161
Self-Healing Injectable Hydrogels for Tissue Regeneration
Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 892
Designing degradable hydrogels for orthogonal control of cell microenvironments
Kharkar, P. M., Kiick, K. L., & Kloxin, A. M. (2013) · Chem. Soc. Rev. · doi:10.1039/c3cs60040h · Cited by 717
Approaches to Sustainable and Continually Recyclable Cross-Linked Polymers
Fortman, D. J., Brutman, J. P., De Hoe, G. X., Snyder, R. L., Dichtel, W. R., & Hillmyer, M. A. (2018) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.8b02355 · Cited by 559
Chang, H., Zheng, M., Yu, X., Than, A., Seeni, R. Z., Kang, R., Tian, J., Khanh, D. P., Liu, L., Chen, P., et al. (2017) · Advanced Materials · doi:10.1002/adma.201702243 · Cited by 462
Metadata
- Authors
- Nimmo, C. M., Owen, S. C., & Shoichet, M. S.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-02-11
- Volume
- 12
- Issue
- 3
- Pages
- 824-830
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2086608111
- Cited by
- 436
- References
- 4
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- green
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