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Diels−Alder Click Cross-Linked Hyaluronic Acid Hydrogels for Tissue Engineering
Open accessAbstract
Hyaluronic acid (HA) is a naturally occurring polymer that holds considerable promise for tissue engineering applications. Current cross-linking chemistries often require a coupling agent, catalyst, or photoinitiator, which may be cytotoxic, or involve a multistep synthesis of functionalized-HA, increasing the complexity of the system. With the goal of designing a simpler one-step, aqueous-based cross-linking system, we synthesized HA hydrogels via Diels-Alder "click" chemistry. Furan-modified HA derivatives were synthesized and cross-linked via dimaleimide poly(ethylene glycol). By controlling the furan to maleimide molar ratio, both the mechanical and degradation properties of the resulting Diels-Alder cross-linked hydrogels can be tuned. Rheological and degradation studies demonstrate that the Diels-Alder click reaction is a suitable cross-linking method for HA. These HA cross-linked hydrogels were shown to be cytocompatible and may represent a promising material for soft tissue engineering.
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Metadata
- Authors
- Nimmo, C. M., Owen, S. C., & Shoichet, M. S.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-02-11
- Volume
- 12
- Issue
- 3
- Pages
- 824-830
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2086608111
- Cited by
- 436
- References
- 4
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- green
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