The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Effect of Polymer Brush Architecture on Antibiofouling Properties
Open accessAbstract
Polymer brushes show great promise in next-generation antibiofouling surfaces. Here, we have studied the influence of polymer brush architecture on protein resistance. By carefully optimizing reaction conditions, we were able to polymerize oligoglycerol-based brushes with sterically demanding linear or dendronized side chains on gold surfaces. Protein adsorption from serum and plasma was analyzed by surface plasmon resonance. Our findings reveal a pronounced dependence of biofouling on brush architecture. Bulky yet flexible side chains as in dendronized brushes provide an ideal environment to repel protein-possibly through formation of a hydration layer, which can be further enhanced by presenting free hydroxyl groups on the polymer brushes. A deeper understanding of how brush architecture influences protein resistance will ultimately enable fabrication of surface coatings tailored to specific requirements in biomedical applications.
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Cites
A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein
Ostuni, E., Chapman, R. G., Holmlin, R. E., Takayama, S., & Whitesides, G. M. (2001) · Langmuir · doi:10.1021/la010384m · Cited by 1,799
Luk, Y.-Y., Kato, M., & Mrksich, M. (2000) · Langmuir · doi:10.1021/la0004653 · Cited by 414
A Switchable Biocompatible Polymer Surface with Self‐Sterilizing and Nonfouling Capabilities
Cheng, G., Xue, H., Zhang, Z., Chen, S., & Jiang, S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200803570 · Cited by 371
Cited by
Antifouling membranes for sustainable water purification: strategies and mechanisms
Zhang, R., Liu, Y., He, M., Su, Y., Zhao, X., Elimelech, M., & Jiang, Z. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00579e · Cited by 1,365
Functional polymer materials for modern marine biofouling control
Qiu, H., Feng, K., Gapeeva, A., Meurisch, K., Kaps, S., Li, X., Yu, L., Mishra, Y. K., Adelung, R., & Baum, M. (2022) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2022.101516 · Cited by 389
The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity
Brash, J. L., Horbett, T. A., Latour, R. A., & Tengvall, P. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.06.022 · Cited by 282
Surface chemistry to minimize fouling from blood-based fluids
Blaszykowski, C., Sheikh, S., & Thompson, M. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35170f · Cited by 271
Thomas, A., Müller, S. S., & Frey, H. (2014) · Biomacromolecules · doi:10.1021/bm5002608 · Cited by 264
Metadata
- Authors
- Gunkel, G., Weinhart, M., Becherer, T., Haag, R., & Huck, W. T. S.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-09-28
- Volume
- 12
- Issue
- 11
- Pages
- 4169-4172
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2078923706
- Cited by
- 160
- References
- 3
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- green
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