The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Stimuli Responsive Self-Assembled Hydrogel of a Low Molecular Weight Free Dipeptide with Potential for Tunable Drug Delivery
Abstract
Bottom-up fabrication by molecular self-assembly is now widely recognized as a potent method for generating interesting and functional nano- and mesoscale structures. Hydrogels from biocompatible molecules are an interesting class of mesoscale assemblies with potential biomedical applications. The self-assembly of a proteolysis resistant aromatic dipeptide containing a conformational constraining residue (DeltaPhe) into a stable hydrogel has been studied in this work. The reported dipeptide has free -N and -C termini. The hydrogel was self-supportive, was fractaline in nature, and possessed high mechanical strength. It was responsive to environmental conditions like pH, temperature, and ionic strength. The gel matrix could encapsulate and release bioactive molecules in a sustained manner. The described hydrogel showed no observable cytotoxicity to the HeLa and L929 cell lines in culture.
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Cites
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Cited by
Biomimetic peptide self-assembly for functional materials
Levin, A., Hakala, T. A., Schnaider, L., Bernardes, G. J. L., Gazit, E., & Knowles, T. P. J. (2020) · Nature Reviews Chemistry · doi:10.1038/s41570-020-0215-y · Cited by 853
Amino Acids and Peptide‐Based Supramolecular Hydrogels for Three‐Dimensional Cell Culture
Dou, X., & Feng, C. (2017) · Advanced Materials · doi:10.1002/adma.201604062 · Cited by 355
Multicomponent peptide assemblies
Raymond, D. M., & Nilsson, B. L. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00115d · Cited by 346
Supramolecular Hybrid Hydrogel Based on Host–Guest Interaction and Its Application in Drug Delivery
Yu, J., Ha, W., Sun, J.-N., & Shi, Y.-P. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am505649q · Cited by 113
Biswas, S., Vasudevan, A., Yadav, N., Yadav, S., Rawal, P., Kaur, I., Tripathi, D. M., Kaur, S., & Chauhan, V. S. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00526 · Cited by 11
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Metadata
- Authors
- Panda, J. J., Mishra, A., Basu, A., & Chauhan, V. S.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-15
- Volume
- 9
- Issue
- 8
- Pages
- 2244-2250
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2002192827
- Cited by
- 168
- References
- 5
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
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