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DNA Nanotubes as Combinatorial Vehicles for Cellular Delivery
Open accessAbstract
This work explores using self-assembled DNA nanostructures as carriers for drug delivery. We have recently developed an organic nanotube system that is assembled from a single component: a 52-base-long DNA single strand. In this work, functional agents (folate as a cancer cell target agent and Cy3 as a fluorescence imaging agent) are conjugated with the DNA strands; the conjugates self-assemble into micrometers-long nanotubes (NTs). The conjugated DNA-NTs can be effectively taken by cancer cells as demonstrated by fluorescence imaging and fluorescence-activated cell sorting. No obvious toxicity has been observed under current experimental conditions.
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Cited by
DNA Nanotechnology-Enabled Drug Delivery Systems
Hu, Q., Li, H., Wang, L., Gu, H., & Fan, C. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00663 · Cited by 1,118
DNA nanotechnology from the test tube to the cell
Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594
Self-citationSmart Drug Delivery Nanocarriers with Self‐Assembled DNA Nanostructures
Li, J., Fan, C., Pei, H., Shi, J., & Huang, Q. (2013) · Advanced Materials · doi:10.1002/adma.201300875 · Cited by 441
Virus-Encapsulated DNA Origami Nanostructures for Cellular Delivery
Mikkilä, J., Eskelinen, A.-P., Niemelä, E. H., Linko, V., Frilander, M. J., Törmä, P., & Kostiainen, M. A. (2014) · Nano Letters · doi:10.1021/nl500677j · Cited by 308
Enhanced resistance of DNA nanostructures to enzymatic digestion
Keum, J.-W., & Bermudez, H. (2009) · Chemical Communications · doi:10.1039/b917661f · Cited by 305
Metadata
- Authors
- Ko, S., Liu, H., Chen, Y., & Mao, C.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-09-27
- Volume
- 9
- Issue
- 11
- Pages
- 3039-3043
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2058727626
- Cited by
- 188
- References
- 0
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
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