The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Non-cytotoxic Silver Nanoparticle-Polysaccharide Nanocomposites with Antimicrobial Activity
Abstract
In this work we study (i) the formation and stabilization of silver nanoparticles in a bioactive chitosan-derived polysaccharide solution, (ii) the antimicrobial properties, either in solution or in 3D hydrogel structures, obtained by mixtures with the polysaccharide alginate, and (iii) the cytotoxicity of the latter nanocomposite materials on different eukaryotic cell lines. Antimicrobial results show that these nanocomposite systems display a very effective bactericidal activity toward both Gram+ and Gram- bacteria. However, the hydrogel does not show any cytotoxic effect toward three different eukaryotic cell lines. This is due to the fact that the nanoparticles, immobilized in the gel matrix, can exert their antimicrobial activity by simple contact with the bacterial membrane, while they can not be uptaken and internalized by eukaryotic cells. This novel finding could advantageously contribute to responding to the growing concerns on the toxicity of nanoparticles and facilitate the use of silver-biopolymer composites in the preparation of biomaterials.
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Cited by
Mohanty, S., Mishra, S., Jena, P., Jacob, B., Sarkar, B., & Sonawane, A. (2012) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2011.11.007 · Cited by 344
Prucek, R., Tuček, J., Kilianová, M., Panáček, A., Kvítek, L., Filip, J., Kolář, M., Tománková, K., & Zbořil, R. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.039 · Cited by 324
Antimicrobial wound dressing and anti-inflammatory efficacy of silver nanoparticles
Hebeish, A., El-Rafie, M. H., EL-Sheikh, M. A., Seleem, A. A., & El-Naggar, M. E. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.01.071 · Cited by 280
Chitosan based metallic nanocomposite scaffolds as antimicrobial wound dressings
Mohandas, A., Deepthi, S., Biswas, R., & Jayakumar, R. (2018) · Bioactive Materials · doi:10.1016/j.bioactmat.2017.11.003 · Cited by 267
The Effect of Silver Nanoparticles on Antioxidant/Pro-Oxidant Balance in a Murine Model
Docea, A. O., Calina, D., Buga, A. M., Zlatian, O., Paoliello, M. M. B., Mogosanu, G. D., Streba, C. T., Popescu, E. L., Stoica, A. E., Bîrcă, A. C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041233 · Cited by 111
Metadata
- Authors
- Travan, A., Pelillo, C., Donati, I., Marsich, E., Benincasa, M., Scarpa, T., Semeraro, S., Turco, G., Gennaro, R., & Paoletti, S.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-04-30
- Volume
- 10
- Issue
- 6
- Pages
- 1429-1435
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1990876870
- Cited by
- 400
- References
- 34
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Travan, A., Pelillo, C., Donati, I., Marsich, E., Benincasa, M., Scarpa, T., Semeraro, S., Turco, G., Gennaro, R., & Paoletti, S. (2009). Non-cytotoxic Silver Nanoparticle-Polysaccharide Nanocomposites with Antimicrobial Activity. Biomacromolecules. https://doi.org/10.1021/bm900039x
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