The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Toward Metabolic Phenomics: Analysis of Genomic Data Using Flux Balances
Abstract
Small genome sequencing and annotations are leading to the definition of metabolic genotypes in an increasing number of organisms. Proteomics is beginning to give insights into the use of the metabolic genotype under given growth conditions. These data sets give the basis for systemically studying the genotype-phenotype relationship. Methods of systems science need to be employed to analyze, interpret, and predict this complex relationship. These endeavors will lead to the development of a new field, tentatively named phenomics. This article illustrates how the metabolic characteristics of annotated small genomes can be analyzed using flux balance analysis (FBA). A general algorithm for the formulation of in silico metabolic genotypes is described. Illustrative analyses of the in silico Escherichia coli K-12 metabolic genotypes are used to show how FBA can be used to study the capabilities of this strain.
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Citations
Cites
Stoichiometric interpretation of Escherichia coli glucose catabolism under various oxygenation rates
Varma, A., Boesch, B. W., & Palsson, B. O. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.8.2465-2473.1993 · Cited by 316
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Cited by
Genome-Scale Reconstruction of the Saccharomyces cerevisiae Metabolic Network
Förster, J., Famili, I., Fu, P., Palsson, B. Ø., & Nielsen, J. (2003) · Genome Research · doi:10.1101/gr.234503 · Cited by 1,069
Self-citationEdwards, J. S., Ibarra, R. U., & Palsson, B. O. (2001) · Nature Biotechnology · doi:10.1038/84379 · Cited by 939
Self-citationMetabolomics and systems biology: making sense of the soup
KELL, D. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.04.012 · Cited by 529
Metabolic modelling of microbes: the flux‐balance approach
Edwards, J. S., Covert, M., & Palsson, B. (2002) · Environmental Microbiology · doi:10.1046/j.1462-2920.2002.00282.x · Cited by 365
Self-citationMarkers and Biomarkers of Endothelium: When Something Is Rotten in the State
Goncharov, N. V., Nadeev, A. D., Jenkins, R. O., & Avdonin, P. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9759735 · Cited by 190
Metadata
- Authors
- Schilling, C. H., Edwards, J. S., & Palsson, B. O.
- Venue
- Biotechnology Progress
- Publisher
- Wiley
- Published
- 1999-06-04
- Volume
- 15
- Issue
- 3
- Pages
- 288-295
- ISSN
- 1520-6033 (ISSN-L)
- 8756-7938
- OpenAlex
- W1987220754
- Cited by
- 191
- References
- 1
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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