The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Metabolic Regulation of Histone Post-Translational Modifications
Open accessAbstract
Histone post-translational modifications regulate transcription and other DNA-templated functions. This process is dynamically regulated by specific modifying enzymes whose activities require metabolites that either serve as cosubstrates or act as activators/inhibitors. Therefore, metabolism can influence histone modification by changing local concentrations of key metabolites. Physiologically, the epigenetic response to metabolism is important for nutrient sensing and environment adaption. In pathologic states, the connection between metabolism and histone modification mediates epigenetic abnormality in complex disease. In this review, we summarize recent studies of the molecular mechanisms involved in metabolic regulation of histone modifications and discuss their biological significance.
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Cites
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
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“Additionally, expression of different HMTs has been demonstrated to vary during development, and folate limitation during these stages leads to distinct outcomes (93, 94).”
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Cited by
Gut microbial metabolites as multi-kingdom intermediates
Krautkramer, K. A., Fan, J., & Bäckhed, F. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0438-4 · Cited by 1,398
Self-citationDiet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues
Krautkramer, K. A., Kreznar, J. H., Romano, K. A., Vivas, E. I., Barrett-Wilt, G. A., Rabaglia, M. E., Keller, M. P., Attie, A. D., Rey, F. E., & Denu, J. M. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.025 · Cited by 607
Self-citationMetabolism of tissue macrophages in homeostasis and pathology
Wculek, S. K., Dunphy, G., Heras-Murillo, I., Mastrangelo, A., & Sancho, D. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00791-9 · Cited by 501
The metabolic fate of acetate in cancer
Schug, Z. T., Vande Voorde, J., & Gottlieb, E. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.87 · Cited by 331
Metabolic regulation of chromatin modifications and gene expression
Schvartzman, J. M., Thompson, C. B., & Finley, L. W. S. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201803061 · Cited by 233
Metadata
- Authors
- Fan, J., Krautkramer, K. A., Feldman, J. L., & Denu, J. M.
- Venue
- ACS Chemical Biology
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-01-06
- Volume
- 10
- Issue
- 1
- Pages
- 95-108
- ISSN
- 1554-8929 (ISSN-L)
- 1554-8937
- OpenAlex
- W2331098390
- Cited by
- 330
- References
- 36
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- green
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