Metabolic regulation of chromatin modifications and gene expression

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

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Reductive carboxylation supports growth in tumour cells with defective mitochondria

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The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription

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R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

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Metabolic regulation of gene expression through histone acylations

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Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

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The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

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Histone core modifications regulating nucleosome structure and dynamics

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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

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Influence of Metabolism on Epigenetics and Disease

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Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein

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Distinct roles of GCN5/PCAF‐mediated H3K9ac and CBP/p300‐mediated H3K18/27ac in nuclear receptor transactivation

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Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

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Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

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Germline DNA Demethylation Dynamics and Imprint Erasure through 5-hydroxymethylcytosine

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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

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Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

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Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

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Acetate dependence of tumors

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Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells

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A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

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COMPASS: A complex of proteins associated with a trithorax-related SET domain protein

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Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals

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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

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Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

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Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

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Naive pluripotency is associated with global DNA hypomethylation

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The impact of cellular metabolism on chromatin dynamics and epigenetics

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Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells

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Hypoxia Induces Production of L-2-Hydroxyglutarate

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Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism

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Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

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Widespread and Enzyme-independent Nϵ-Acetylation and Nϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix*

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Looping Back to Leap Forward: Transcription Enters a New Era

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Whole-Genome Bisulfite Sequencing of Two Distinct Interconvertible DNA Methylomes of Mouse Embryonic Stem Cells

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Substrate and sequence specificity of a eukaryotic DNA methylase

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The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

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Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine

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Structural basis of transcription initiation by RNA polymerase II

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A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activitiesPreprint

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SDH mutations in cancer

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Acetylation in Histone H3 Globular Domain Regulates Gene Expression in Yeast

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FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

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Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

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Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

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Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

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BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

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Untitled work

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LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

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Metabolic Regulation of Histone Post-Translational Modifications

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Nutrient-Sensing Mechanisms across Evolution

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