The metabolic fate of acetate in cancer

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

Innate and adaptive immune cells in the tumor microenvironment

Gajewski, T. F., Schreiber, H., & Fu, Y.-X. (2013) · Nature Immunology · doi:10.1038/ni.2703 · Cited by 4,148 · see citing works

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · see citing works

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works

Short chain fatty acids in human large intestine, portal, hepatic and venous blood

Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119 · see citing works

The gut microbiota, bacterial metabolites and colorectal cancer

Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,836 · see citing works

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409 · see citing works

ATP-citrate lyase links cellular metabolism to histone acetylation

Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298 · see citing works

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,228 · see citing works

Sirtuins as regulators of metabolism and healthspan

Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3293 · Cited by 2,008 · see citing works

The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon

Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003 · see citing works

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

Sonveaux, P., Végran, F., Schroeder, T., Wergin, M., Verrax, J., Rabbani, Z. N., Saedeleer, C. J. D., Kennedy, K. M., Diepart, C., Jordan, B. F., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36843 · Cited by 1,633 · see citing works

Regulation of immune cell function by short‐chain fatty acids

Corrêa‐Oliveira, R., Fachi, J. L., Vieira, A., Sato, F. T., & Vinolo, M. A. R. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.17 · Cited by 1,346 · see citing works

Molecular mechanisms of alcohol-mediated carcinogenesis

Seitz, H. K., & Stickel, F. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2191 · Cited by 1,142 · see citing works

Metabolic heterogeneity in human lung tumors

Hensley, C. T., Faubert, B., Yuan, Q., Lev-Cohain, N., Jin, E., Kim, J., Jiang, L., Ko, B., Skelton, R., Loudat, L., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.034 · Cited by 1,138 · see citing works

ATP citrate lyase inhibition can suppress tumor cell growth

Hatzivassiliou, G., Zhao, F., Bauer, D. E., Andreadis, C., Shaw, A. N., Dhanak, D., Hingorani, S. R., Tuveson, D. A., & Thompson, C. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.09.008 · Cited by 1,086 · see citing works

The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism

Ullah, M. S., Davies, A. J., & Halestrap, A. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511397200 · Cited by 894 · see citing works

Autotrophy at the thermodynamic limit of life: a model for energy conservation in acetogenic bacteria

Schuchmann, K., & Müller, V. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3365 · Cited by 845 · see citing works

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.002 · Cited by 820 · see citing works

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

Hallows, W. C., Lee, S., & Denu, J. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604392103 · Cited by 792 · see citing works

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases

Mashimo, T., Pichumani, K., Vemireddy, V., Hatanpaa, K. J., Singh, D. K., Sirasanagandla, S., Nannepaga, S., Piccirillo, S. G., Kovacs, Z., Foong, C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.025 · Cited by 760 · see citing works

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

Davidson, S. M., Papagiannakopoulos, T., Olenchock, B. A., Heyman, J. E., Keibler, M. A., Luengo, A., Bauer, M. R., Jha, A. K., O’Brien, J. P., Pierce, K. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.007 · Cited by 737 · see citing works

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

Schwer, B., Bunkenborg, J., Verdin, R. O., Andersen, J. S., & Verdin, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603968103 · Cited by 705 · see citing works

Fatty acid synthesis: a potential selective target for antineoplastic therapy

Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., & Pasternack, G. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6379 · Cited by 705 · see citing works

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A. K., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.020 · Cited by 681 · see citing works

Disrupting proton dynamics and energy metabolism for cancer therapy

Parks, S. K., Chiche, J., & Pouysségur, J. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3579 · Cited by 613 · see citing works

Acetate and Propionate Short Chain Fatty Acids Stimulate Adipogenesis via GPCR43

Hong, Y.-H., Nishimura, Y., Hishikawa, D., Tsuzuki, H., Miyahara, H., Gotoh, C., Choi, K.-C., Feng, D. D., Chen, C., Lee, H.-G., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0545 · Cited by 613 · see citing works

Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine

Starai, V. J., Celic, I., Cole, R. N., Boeke, J. D., & Escalante-Semerena, J. C. (2002) · Science · doi:10.1126/science.1077650 · Cited by 564 · see citing works

Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

Lee, J. V., Carrer, A., Shah, S., Snyder, N. W., Wei, S., Venneti, S., Worth, A. J., Yuan, Z.-F., Lim, H.-W., Liu, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.004 · Cited by 563 · see citing works

ATP citrate lyase is an important component of cell growth and transformation

Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208773 · Cited by 537 · see citing works

Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism

Robertson, M. D., Bickerton, A. S. T., Dennis, A., Vidal, H., & Frayn, K. N. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.3.559 · Cited by 503 · see citing works

Insulin-Sensitizing Effects of Dietary Resistant Starch and Effects on Skeletal Muscle and Adipose Tissue Metabolism

Robertson, M. D., Bickerton, A. S., Dennis, A. L., Vidal, H., & Frayn, K. N. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.559 · Cited by 501 · see citing works

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stressPreprint

Zaugg, K., Yao, Y., Reilly, P. T., Kannan, K., Kiarash, R., Mason, J. M., Huang, P., Sawyer, S. K., Fuerth, B. J., Faubert, B., et al. (2011) · Genes & Development · doi:10.1101/gad.1987211 · Cited by 493 · see citing works

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

Gao, X. J., Lin, S., Ren, F., Li, J.-T., Chen, J.-J., Yao, C.-B., Yang, H., Jiang, S.-X., Yan, G.-Q., Wang, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms11960 · Cited by 481 · see citing works

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

Ge, H., Li, X., Weiszmann, J., Wang, P., Baribault, H., Chen, J., Tian, H., & Li, Y. (2008) · Endocrinology · doi:10.1210/en.2008-0059 · Cited by 477 · see citing works

Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription

Takahashi, H., McCaffery, J. M., Irizarry, R. A., & Boeke, J. D. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.040 · Cited by 438 · see citing works

Dissecting the in Vivo Metabolic Potential of Two Human Gut Acetogens

Rey, F. E., Faith, J. J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Newgard, C. B., & Gordon, J. I. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.117713 · Cited by 417 · see citing works

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

Bloemen, J. G., Venema, K., van de Poll, M. C., Olde Damink, S. W., Buurman, W. A., & Dejong, C. H. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.05.011 · Cited by 382 · see citing works

Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

Watkins, P. A., Maiguel, D. A., Jia, Z., & Pevsner, J. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700378-jlr200 · Cited by 378 · see citing works

Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood.

Pomare, E. W., Branch, W. J., & Cummings, J. H. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111847 · Cited by 356 · see citing works

Vascular Permeability and Drug Delivery in Cancers

Azzi, S., Hebda, J. K., & Gavard, J. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00211 · Cited by 352 · see citing works

ETHANOL METABOLISM AND PRODUCTION OF FREE ACETATE IN THE HUMAN LIVER

Lundquist, F., Tygstrup, N., WINKLER, K., Mellemgaard, K., & Munck-Petersen, S. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104574 · Cited by 350 · see citing works

Metabolism of [U‐ ¹³ C]glucose in human brain tumors <i>in vivo</i>

Maher, E. A., Marin‐Valencia, I., Bachoo, R. M., Mashimo, T., Raisanen, J., Hatanpaa, K. J., Jindal, A., Jeffrey, F. M., Choi, C., Madden, C., et al. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2794 · Cited by 341 · see citing works

Metabolic Regulation of Histone Post-Translational Modifications

Fan, J., Krautkramer, K. A., Feldman, J. L., & Denu, J. M. (2015) · ACS Chemical Biology · doi:10.1021/cb500846u · Cited by 334 · see citing works

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

Tang, C., Ahmed, K., Gille, A., Lu, S. Y., Gröne, H., Tunaru, S., & Offermanns, S. (2015) · Nature Medicine · doi:10.1038/nm.3779 · Cited by 332 · see citing works

Acetyl-CoA Synthetase 2, a Mitochondrial Matrix Enzyme Involved in the Oxidation of Acetate

Fujino, T., Kondo, J., Ishikawa, M., Morikawa, K., & Yamamoto, T. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008782200 · Cited by 298 · see citing works

SLC5A8 , a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers

Li, H., Myeroff, L. L., Smiraglia, D. J., Romero, M. F., Pretlow, T. P., Kasturi, L., Lutterbaugh, J., Rerko, R. M., Casey, G., Issa, J. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1430846100 · Cited by 295 · see citing works

11C-acetate PET imaging in prostate cancer

Morris, M. J., & Scher, H. I. (2006) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-006-0281-5 · Cited by 294 · see citing works

Prostate Cancer: PET with 18F-FDG, 18F- or 11C-Acetate, and 18F- or 11C-Choline

Jadvar, H. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.077941 · Cited by 290 · see citing works

A Prospective Evaluation of 18 F-FDG and 11 C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

Park, J., Kim, J. H., Kim, S. K., et al. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.055087 · Cited by 287 · see citing works

Causes and Effects of Heterogeneous Perfusion in Tumors

Gillies, R. J., Schomack, P. A., Secomb, T. W., & Raghunand, N. (1999) · Neoplasia · doi:10.1038/sj.neo.7900037 · Cited by 283 · see citing works

G‐protein‐coupled receptor for short‐chain fatty acids suppresses colon cancer

Tang, Y., Chen, Y., Jiang, H., Robbins, G. T., & Nie, D. (2010) · International Journal of Cancer · doi:10.1002/ijc.25638 · Cited by 282 · see citing works

Functional Identification of SLC5A8, a Tumor Suppressor Down-regulated in Colon Cancer, as a Na+-coupled Transporter for Short-chain Fatty Acids

Miyauchi, S., Gopal, E., Fei, Y.-J., & Ganapathy, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400059200 · Cited by 277 · see citing works

Histone Acetylation Regulates Intracellular pH

McBrian, M. A., Behbahan, I. S., Ferrari, R., Su, T., Huang, T.-W., Li, K., Hong, C. S., Christofk, H. R., Vogelauer, M., Seligson, D. B., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.025 · Cited by 272 · see citing works

Molecular Characterization of Human Acetyl-CoA Synthetase, an Enzyme Regulated by Sterol Regulatory Element-binding Proteins

Luong, A., Hannah, V. C., Brown, M. S., & Goldstein, J. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004160200 · Cited by 266 · see citing works

Alcoholic disease: Liver and beyond

Rocco, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14652 · Cited by 260 · see citing works

Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas

Pinheiro, C. M., Longatto‐Filho, A., Scapulatempo‐Neto, C., Ferreira, L., Martins, S. F. F., Pellerin, L., Rodrigues, M., Alves, V. A. F., Schmitt, F. C., & Baltazar, F. (2008) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-007-0558-5 · Cited by 254 · see citing works

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

Peck, B., Schug, Z. T., Zhang, Q., Dankworth, B., Jones, D. T., Smethurst, E. A., Patel, R., Mason, S. M., Jiang, M., Saunders, R. E., et al. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0146-8 · Cited by 254 · see citing works

Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate

Kamphorst, J. J., Chung, M. K., Fan, J., & Rabinowitz, J. D. (2014) · Cancer &amp; Metabolism · doi:10.1186/2049-3002-2-23 · Cited by 227 · see citing works

Positron emission tomography imaging of brain tumors

Wong, T. Z., van der Westhuizen, G. J., & Coleman, R. E. (2002) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(02)00033-3 · Cited by 207 · see citing works

Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport

Bola, B. M., Chadwick, A. L., Michopoulos, F., Blount, K. G., Telfer, B. A., Williams, K. J., Smith, P. D., Critchlow, S. E., & Stratford, I. J. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-1091 · Cited by 205 · see citing works

Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers

Nath, A., & Chan, C. (2016) · Scientific Reports · doi:10.1038/srep18669 · Cited by 195 · see citing works

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion

Priyadarshini, M., Villa, S. R., Fuller, M. H., Wicksteed, B. L., Mackay, C. R., Alquier, T., Poitout, V., Mancebo, H. S. Y., Mirmira, R. G., Gilchrist, A., et al. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1007 · Cited by 188 · see citing works

Role of acetate in the reduction of plasma free fatty acids produced by ethanol in man

Crouse, J. R., Gerson, C. D., DeCarli, L. M., & Lieber, C. S. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42731-2 · Cited by 184 · see citing works

The Kinetics, Substrate, and Inhibitor Specificity of the Monocarboxylate (Lactate) Transporter of Rat Liver Cells Determined Using the Fluorescent Intracellular pH Indicator, 2′,7′-Bis(carboxyethyl)-5(6)-carboxyfluorescein

Jackson, V. N., & Halestrap, A. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.861 · Cited by 173 · see citing works

Acetate, the Key Modulator of Inflammatory Responses in Acute Alcoholic Hepatitis

Kendrick, S. F. W., O’Boyle, G., Mann, J., Zeybel, M., Palmer, J. M., Jones, D. E. J., & Day, C. (2010) · Hepatology · doi:10.1002/hep.23572 · Cited by 169 · see citing works

The human tumour suppressor gene SLC5A8 expresses a Na+–monocarboxylate cotransporter

Coady, M. J., Chang, M., Charron, F. M., Plata, C., Wallendorff, B., Sah, J. F., Markowitz, S. D., Romero, M. F., & Lapointe, J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063859 · Cited by 166 · see citing works

Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner

Chen, R., Dioum, E. M., Hogg, R. T., Gerard, R. D., & Garcia, J. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.175414 · Cited by 155 · see citing works

1-11C-Acetate as a PET Radiopharmaceutical for Imaging Fatty Acid Synthase Expression in Prostate Cancer

Vāvere, A. L., Kridel, S. J., Wheeler, F. B., & Lewis, J. S. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.046672 · Cited by 154 · see citing works

Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization

Björnson, E., Mukhopadhyay, B., Asplund, A., Pristovšek, N., Çınar, R., Romeo, S., Uhlén, M., Kunos, G., Nielsen, J., & Mardinoğlu, A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.045 · Cited by 142 · see citing works

18F-fluoroacetate: a potential acetate analog for prostate tumor imaging--in vivo evaluation of 18F-fluoroacetate versus 11C-acetate.

Ponde, D. E., Dence, C. S., Oyama, N., Kim, J., Tai, Y., Laforest, R. A., Siegel, B. A., & Welch, M. J. (2007) · PubMed · Cited by 134 · see citing works

11C-acetate PET imaging of prostate cancer.

Oyama, N., Akino, H., Kanamaru, H., Suzuki, Y., Muramoto, S., Yonekura, Y., Sadato, N., Yamamoto, K., & Okada, K. (2002) · PubMed · Cited by 133 · see citing works

18F-Choline, 11C-choline and 11C-acetate PET/CT: comparative analysis for imaging prostate cancer patients

Brogsitter, C., Zöphel, K., & Kotzerke, J. (2013) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-013-2358-2 · Cited by 133 · see citing works

Portal and peripheral blood short chain fatty acid concentrations after caecal lactulose instillation at surgery.

Peters, S. G., Pomare, E. W., & Fisher, C. A. (1992) · Gut · doi:10.1136/gut.33.9.1249 · Cited by 124 · see citing works

18F-FDG PET Scanning Correlates with Tissue Markers of Poor Prognosis and Predicts Mortality for Patients After Liver Resection for Colorectal Metastases

Riedl, C. C., Akhurst, T., Larson, S. M., et al. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.106.037291 · Cited by 121 · see citing works

11C-Acetate PET/CT in Localized Prostate Cancer: A Study with MRI and Histopathologic Correlation

Mena, E., Türkbey, B., Mani, H., Adler, S., Valera, V., Bernardo, M., Shah, V. P., Pohida, T. J., McKinney, Y. L., Kwarteng, G., et al. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.096032 · Cited by 119 · see citing works

ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms

Zaidi, N., Royaux, I. E., Swinnen, J. V., & Smans, K. A. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0095 · Cited by 116 · see citing works

Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line

Yonezawa, T., Kobayashi, Y., & Obara, Y. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.06.004 · Cited by 109 · see citing works

Cytosolic acetyl‐CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl‐CoA/acetate metabolism

Yoshii, Y., Furukawa, T., Yoshii, H., Mori, T., Kiyono, Y., Waki, A., Kobayashi, M., Tsujikawa, T., Kudo, T., Okazawa, H., et al. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01099.x · Cited by 108 · see citing works

Resistant starch in the diet increases breath hydrogen and serum acetate in human subjects

Muir, J., Lu, Z., Young, G. P., Cameron‐Smith, D., Collier, G., & O’Dea, K. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.4.792 · Cited by 106 · see citing works

The contribution of the large intestine to blood acetate in man

Scheppach, W. M., Pomare, E. W., Elia, M., & Cummings, J. H. (1991) · Clinical Science · doi:10.1042/cs0800177 · Cited by 106 · see citing works

Volatile fatty acids in human peripheral and portal blood: Quantitative determination by vacuum distillation and gas chromatography

Dankert, J., Zijlstra, J. B., & Wolthers, B. G. (1981) · Clinica Chimica Acta · doi:10.1016/0009-8981(81)90359-4 · Cited by 104 · see citing works

Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting

Spriet, L. L., Tunstall, R. J., Watt, M. J., Carey, K. A., Hargreaves, M., & Cameron‐Smith, D. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01318.2003 · Cited by 102 · see citing works

Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: Overview and application

Yoshii, Y., Furukawa, T., Saga, T., & Fujibayashi, Y. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.02.019 · Cited by 100 · see citing works

Radiation dose estimates in humans for (11)C-acetate whole-body PET.

SELTZER, M. A., Jahan, S. A., Sparks, R. B., et al. (2004) · PubMed · Cited by 97 · see citing works

SUBCELLULAR DISTRIBUTION OF ACETYL‐CoA SYNTHETASE, ATP CITRATE LYASE, CITRATE SYNTHASE, CHOLINE ACETYLTRANSFERASE, FUMARATE HYDRATASE AND LACTATE DEHYDROGENASE IN MAMMALIAN BRAIN TISSUE

Tucek, S. (1967) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1967.tb09552.x · Cited by 96 · see citing works

Measurement of acetate in human blood by gas chromatography: effects of sample preparation, feeding, and various diseases.

TOLLINGER, C. D., Vreman, H. J., & Weiner, M. W. (1979) · Clinical Chemistry · doi:10.1093/clinchem/25.10.1787 · Cited by 92 · see citing works

Elevated blood acetate as indicator of fast ethanol elimination in chronic alcoholics

Nuutinen, H. U., Lindros, K. O., Hekali, P. E., & Salaspuro, M. P. (1985) · Alcohol · doi:10.1016/0741-8329(85)90090-4 · Cited by 88 · see citing works

An acetate switch regulates stress erythropoiesis

Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H. C., Moon, Y.-A., Gerard, R. D., Huang, C.-L., Comerford, S. A., Hammer, R. E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3587 · Cited by 87 · see citing works

Significance of Short Chain Fatty Acid Transport by Members of the Monocarboxylate Transporter Family (MCT)

Moschén, I., Bröer, A., Galić, S., Lang, F. J. W., & Bröer, S. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0857-3 · Cited by 84 · see citing works

Acetate, propionate and butyrate in plasma: determination of the concentration and isotopic enrichment by gas chromatography/mass spectrometry with positive chemical ionization

Pouteau, E., Meirim, I., Métairon, S., & Fay, L. (2001) · Journal of Mass Spectrometry · doi:10.1002/jms.181 · Cited by 77 · see citing works

The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

Chen, R., Xu, M., Nagati, J. S., Hogg, R. T., Das, A., Gerard, R. D., & Garcia, J. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116515 · Cited by 76 · see citing works

A Tale of Metabolites: The Cross-Talk between Chromatin and Energy Metabolism

Martínez-Pastor, B., Cosentino, C., & Mostoslavsky, R. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0059 · Cited by 76 · see citing works

Metabolism as a key to histone deacetylase inhibition

Rajendran, P., Williams, D. E., Ho, E., & Dashwood, R. H. (2011) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2011.557713 · Cited by 75 · see citing works

11C-Acetate PET in the Evaluation of Brain Glioma: Comparison with 11C-Methionine and 18F-FDG-PET

Yamamoto, Y., Nishiyama, Y., Kimura, N., Kameyama, R., Kawai, N., Hatakeyama, T., Kaji, M., & Ohkawa, M. (2008) · Molecular Imaging and Biology · doi:10.1007/s11307-008-0152-5 · Cited by 74 · see citing works

Absorption of Short-Chain Fatty Acids from the Rat Cecum in Vivo

Fleming, S. E., Choi, S. Y., & Fitch, M. D. (1991) · Journal of Nutrition · doi:10.1093/jn/121.11.1787 · Cited by 72 · see citing works

Grading of brain glioma with 1-11C-acetate PET: comparison with 18F-FDG PET

Tsuchida, T., Takeuchi, H., Okazawa, H., Tsujikawa, T., & Fujibayashi, Y. (2008) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2007.11.004 · Cited by 72 · see citing works

Effect of Moderate Alcohol Consumption on Hypertriglyceridemia: A Study in the Fasting State

Pownall, H. J., Ballantyne, C. M., Kimball, K. T., Simpson, S. L., Yeshurun, D., & Gotto, A. M. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.9.981 · Cited by 70 · see citing works

1-11C-Acetate Kinetics of Prostate Cancer

Schiepers, C. W., Hoh, C. K., Nuyts, J. L., et al. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.044453 · Cited by 66 · see citing works

Extracellular pH regulation in microdomains of colonic crypts: effects of short-chain fatty acids.

Chu, S., & Montrose, M. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3303 · Cited by 65 · see citing works

Bicarbonate-stimulated [14C]butyrate uptake in basolateral membrane vesicles of rat distal colon

Reynolds, D. A., Rajendran, V. M., & Binder, H. J. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90889-k · Cited by 63 · see citing works

11C-Acetate PET imaging for renal cell carcinoma

Oyama, N., Okazawa, H., Kusukawa, N., et al. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0981-0 · Cited by 60 · see citing works

11C-Acetate PET/CT for Metabolic Characterization of Multiple Myeloma: A Comparative Study with 18F-FDG PET/CT

Ho, C.-L., Chen, S., Leung, Y. L., et al. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.131169 · Cited by 60 · see citing works

Metabolomic Analysis Reveals Extended Metabolic Consequences of Marginal Vitamin B-6 Deficiency in Healthy Human Subjects

Gregory, J. F., Park, Y. H., Lamers, Y., Bandyopadhyay, N., Chi, Y.-Y., Lee, K., Kim, S., da Silva, V., Hove, N. K., Ranka, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063544 · Cited by 59 · see citing works

Inulin increases short-term markers for colonic fermentation similarly in healthy and hyperinsulinaemic humans

Fernandes, J., Vogt, J. A., & Wolever, T. M. S. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.116 · Cited by 49 · see citing works

Monocarboxylate transporter 1 (MCT1) mediates transport of short‐chain fatty acids in bovine caecum

Kirat, D., & Kato, S. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033837 · Cited by 49 · see citing works

Research into cancer metabolomics: Towards a clinical metamorphosis

Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E., & Halsey, C. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.09.008 · Cited by 45 · see citing works

Production rate of acetate during colonic fermentation of lactulose: a stable-isotope study in humans

Pouteau, E. B., Vahedi, K., Messing, B., et al. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1276 · Cited by 44 · see citing works

The relationship of plasma acetate with glucose and other blood intermediary metabolites in non-diabetic and diabetic subjects

Akanji, A. O., Humphreys, S. M., Thursfield, V. J., et al. (1989) · Clinica Chimica Acta · doi:10.1016/0009-8981(89)90127-7 · Cited by 43 · see citing works

Metabolism of neoplastic tissue. XIII. Substrate competition in fatty acid oxidation in ascites tumor cells.

Medes, G., & Weinhouse, S. (1958) · PubMed · Cited by 41 · see citing works

Fatty acid metabolism. VIII. Acetate metabolism in vitro during hepatocarcinogenesis by p-dimethylaminoazobenzene.

Medes, G., Friedmann, B., & Weinhouse, S. (1956) · PubMed · Cited by 40 · see citing works

Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening

Hatanaka, H., Tsukui, M., Takada, S., et al. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01348.x · Cited by 35 · see citing works

Enzymatic and transcriptional regulation of the cytoplasmic acetyl-CoA hydrolase ACOT12

Horibata, Y., Ando, H., Itoh, M., & Sugimoto, H. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m030163 · Cited by 32 · see citing works

Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase.

Suematsu, N., & Isohashi, F. (2006) · Acta Biochimica Polonica · doi:10.18388/abp.2006_3327 · Cited by 29 · see citing works

Metabolism of neoplastic tissues. XI. Absorption and oxidation of dietary fatty acids by implanted tumors.

Medes, G., Paden, G., & Weinhouse, S. (1957) · PubMed · Cited by 29 · see citing works

Late Imaging with [1-11C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET

Lewis, D. Y., Boren, J., Shaw, G. L., Bielik, R., Ramos‐Montoya, A., Larkin, T. J., Martins, C. P., Neal, D. E., Soloviev, D., & Brindle, K. M. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.134437 · Cited by 29 · see citing works

Measurement of whole body acetate turnover in healthy subjects with stable isotopes

Simoneau, C., Pouteau, E. B., Maugeais, P., et al. (1994) · Journal of Mass Spectrometry · doi:10.1002/bms.1200230707 · Cited by 22 · see citing works

Correlation of fluorodeoxyglucose uptake and tumor-proliferating antigen Ki-67 in lymphomas

Lu, J., Shou, Y., Chen, T., et al. (2012) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.95182 · Cited by 21 · see citing works

The Nurture of Tumors Can Drive Their Metabolic Phenotype

Schug, Z. T., Voorde, J. V., & Gottlieb, E. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.016 · Cited by 16 · see citing works

Plasma acetate levels in response to intravenous fat or infusions in diabetic and non-diabetic subjects

Akanji, A. O., Ng, L. L., & Humphreys, S. M. (1988) · Clinica Chimica Acta · doi:10.1016/0009-8981(88)90272-0 · Cited by 13 · see citing works

Protein Expressions and Genetic Variations of SLC5A8 in Prostate Cancer Risk and Aggressiveness

Lin, H., Park, H. Y., Radlein, S., et al. (2011) · Urology · doi:10.1016/j.urology.2011.04.055 · Cited by 12 · see citing works

The multifaceted roles of fatty acid synthesis in cancer

Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651 · see citing works

The cancer metabolic reprogramming and immune response

Xia, L., Oyang, L., Lin, J., Tan, S., Han, Y., Wu, N., Yi, P., Tang, L., Pan, Q., Rao, S., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01316-8 · Cited by 1,312 · see citing works

Metabolism of immune cells in cancer

Leone, R. D., & Powell, J. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0273-y · Cited by 877 · see citing works

Regulation and function of the mammalian tricarboxylic acid cycle

Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535 · see citing works

ATP-citrate lyase controls a glucose-to-acetate metabolic switch

Zhao, S., Torres, A., Henry, R. A., Trefely, S., Wallace, M., Lee, J. V., Carrer, A., Sengupta, A., Campbell, S. L., Kuo, Y.-M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.069 · Cited by 394 · see citing works

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

Patra, K. C., Kato, Y., Mizukami, Y., Widholz, S., Boukhali, M., Revenco, I., Grossman, E. A., Ji, F., Sadreyev, R. I., Liss, A. S., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0122-3 · Cited by 192 · see citing works

Metabolic reprogramming in tumors: Contributions of the tumor microenvironment

Lane, A. N., Higashi, R. M., & Fan, T. W.-M. (2020) · Genes &amp; Diseases · doi:10.1016/j.gendis.2019.10.007 · Cited by 91 · see citing works

Acetyl-CoA metabolism as a therapeutic target for cancer

Chen, G., Bao, B., Cheng, Y., Tian, M., Song, J., Zheng, L., & Tong, Q. (2023) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2023.115741 · Cited by 54 · see citing works

Gut microbial metabolites in cancer therapy

Song, P., Peng, Z., & Guo, X. (2025) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2024.06.016 · Cited by 38 · see citing works

Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer

Zhao, J., Bai, H., Li, X., Yan, J., Zou, G., Wang, L., Li, X., Liu, Z., Xiang, R., Yang, X.-L., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00714-0 · Cited by 27 · see citing works

Energy stress and adaptation strategy of tumor cells in different microenvironments: from primary tumors to distant metastases

Xu, M., Fei, J., Xiao, Z.-X., & Yi, Y. (2026) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025106 · Cited by 2 · see citing works

Mechanism of Temperature Regulator and Application of Home Produced Regulator

Wang, Y.-Y., & Shanghai, S. (2006) · Pharmaceutical & Engineering Design

On the Replacement of Electronic Regulator in Vehicles

Shengwei, X. (2007) · Journal of Sichuan Vocational and Technical College

Characteristics of low-output flow-stabilized regulator under high working pressure

Chi-min, Z. (2011) · Journal of Rocket Propulsion · Cited by 1 · see citing works

FLOW CHARACTERISTICS MEASUREMENT OF REGULATOR BASED ON ONE FILLING-FOR-ONCE METHOD

Fan, W. (2007) · Chinese Journal of Mechanical Engineering

The vehicle uses the alternator and regulator's correct match and the use

Wen-tian, Z. (2009) · Journal of Qinghai Normal University