The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Metabolic Regulation of Histone Post-Translational Modifications
Open accessAbstract
Histone post-translational modifications regulate transcription and other DNA-templated functions. This process is dynamically regulated by specific modifying enzymes whose activities require metabolites that either serve as cosubstrates or act as activators/inhibitors. Therefore, metabolism can influence histone modification by changing local concentrations of key metabolites. Physiologically, the epigenetic response to metabolism is important for nutrient sensing and environment adaption. In pathologic states, the connection between metabolism and histone modification mediates epigenetic abnormality in complex disease. In this review, we summarize recent studies of the molecular mechanisms involved in metabolic regulation of histone modifications and discuss their biological significance.
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Metadata
- Authors
- Fan, J., Krautkramer, K. A., Feldman, J. L., & Denu, J. M.
- Venue
- ACS Chemical Biology
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-01-06
- Volume
- 10
- Issue
- 1
- Pages
- 95-108
- ISSN
- 1554-8929 (ISSN-L)
- 1554-8937
- OpenAlex
- W2331098390
- Cited by
- 330
- References
- 36
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- green
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