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Cited by 320

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Conjugation of DNA to Silanized Colloidal Semiconductor Nanocrystalline Quantum Dots

Open access
Parak, Wolfgang J., Gerion, Daniele, Zanchet, Daniela, Woerz, Anke S., Pellegrino, Teresa, Micheel, Christine, Williams, Shara C., Seitz, Markus, Bruehl, Richard E., Bryant, Zev, Bustamante, Carlos, Bertozzi, Carolyn R., Alivisatos, A. Paul·2002·Chemistry of Materials

Abstract

Water-soluble, highly fluorescent, silanized semiconductor nanocrystals with different surface charges were synthesized. To covalently attach the nanocrystals to biological macromolecules with a variety of mild coupling chemistries, the outermost siloxane shells were derivatized with thiol, amino, or carboxyl functional groups. Single- or double-stranded DNA was coupled to the nanocrystal surfaces by using commercially available bifunctional cross-linker. Conjugation had little effect on the optical properties of the nanocrystals, and the resulting conjugates were more stable than previously reported systems. By using the strategies developed in this study, most biomolecules can be covalently coupled to semiconductor nanocrystals. These nanocrystal-DNA conjugates promise to be a versatile tool for fluorescence imaging and probing of biological systems.

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Crossref · 10.1021/cm0107878

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Metadata

Authors
Parak, W. J., Gerion, D., Zanchet, D., Woerz, A. S., Pellegrino, T., Micheel, C., Williams, S. C., Seitz, M., Bruehl, R. E., Bryant, Z., Bustamante, C., Bertozzi, C. R., & Alivisatos, A. P.
Venue
Chemistry of Materials
Published
2002-04-23
Volume
14
Issue
5
Pages
2113-2119
ISSN
  • 0897-4756 (ISSN-L)
  • 1520-5002
OpenAlex
W2088655601
Cited by
320
References
15
FWCI
14.97
Type
journal article
Language
en
Open access
green

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