From iron oxide nanoparticles towards advanced iron-based inorganic materials designed for biomedical applications
Abstract
In the last decade the progress achieved on the synthesis of inorganic nanostructures has been accompanied by the parallel exploitation of these systems in various fields, among them are biology and medicine. We provide here an overview of the iron-based inorganic nanostructured materials that have been developed and tested in these fields. We will highlight the major concepts on the preparation, physical properties and applications of such nanostructures, starting from the most investigated iron oxide nanoparticles. We will describe then the new generation of inorganic hybrid nanostructures, which are structures that integrate in each nano-object multiple inorganic nanocrystals of different materials. In our discussion we will focus on those works that have provided a sound proof of concept on the potential of the various systems as diagnostic and therapeutic agents.
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Iron oxide nanoparticles are used for a wide variety of biomedical and bioengineering applications.
“Iron oxide nanoparticles, which belong to the ferrimagnetic class of magnetic materials, are used for a wide variety of biomedical and bioengineering applications [1, 2].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [1]
Cites
Magnetic Nanoparticles: Synthesis, Protection, Functionalization, and Application
Lu, A., Salabaş, E. L., & Schüth, F. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200602866 · Cited by 6,788 · see citing works
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565 · see citing works
Applications of magnetic nanoparticles in biomedicine
Pankhurst, Q. A., Connolly, J., Jones, S. K., & Dobson, J. (2003) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/36/13/201 · Cited by 5,898 · see citing works
In vivo cancer targeting and imaging with semiconductor quantum dots
Gao, X., Cui, Y., Levenson, R. M., Chung, L. W. K., & Nie, S. (2004) · Nature Biotechnology · doi:10.1038/nbt994 · Cited by 4,775 · see citing works
Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076 · see citing works
In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles
Dubertret, B., Skourides, P., Norris, D. J., Noireaux, V., Brivanlou, A. H., & Libchaber, A. (2002) · Science · doi:10.1126/science.1077194 · Cited by 3,019 · see citing works
A general strategy for nanocrystal synthesis
Wang, X., Zhuang, J., Peng, Q., & Li, Y. (2005) · Nature · doi:10.1038/nature03968 · Cited by 2,580 · see citing works
Applications of Magnetic Nanoparticles in Biomedicine
Bárcena, C., Sra, A. K., & Gao, J. (2009) · Springer eBooks · doi:10.1007/978-0-387-85600-1_20 · Cited by 2,566 · see citing works
Heating magnetic fluid with alternating magnetic field
Rosensweig, R. E. (2002) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(02)00706-0 · Cited by 2,552 · see citing works
Wu, X., Liu, H., Liu, J., Haley, K. N., Treadway, J. A., Larson, J., Ge, N., Peale, F., & Bruchez, M. P. (2002) · Nature Biotechnology · doi:10.1038/nbt764 · Cited by 2,506 · see citing works
Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo
Larson, D. R., Zipfel, W. R., Williams, R. M., Clark, S. W., Bruchez, M. P., Wise, F. W., & Webb, W. W. (2003) · Science · doi:10.1126/science.1083780 · Cited by 2,290 · see citing works
Modern Magnetic Materials: Principles and Applications
O’Handley, R. C. (1999) · Cited by 1,908 · see citing works
Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
Lee, J.-H., Huh, Y.-M., Jun, Y.-W., Seo, J.-W., Jang, J.-T., Song, H.-T., Kim, S., Cho, E.-J., Yoon, H.-G., Suh, J.-S., et al. (2007) · Nature Medicine · doi:10.1038/nm1467 · Cited by 1,897 · see citing works
Synthesis of Nanosized Gold−Silica Core−Shell Particles
Liz‐Marzán, L. M., Giersig, M., & Mulvaney, P. A. (1996) · Langmuir · doi:10.1021/la9601871 · Cited by 1,856 · see citing works
Magnetic nanoparticle design for medical diagnosis and therapy
Mornet, S., Vasseur, S., Grasset, F., & Duguet, É. (2004) · Journal of Materials Chemistry · doi:10.1039/b402025a · Cited by 1,745 · see citing works
Lewin, M., Carlesso, N., Tung, C., Tang, X. S., Cory, D. G., Scadden, D. T., & Weissleder, R. (2000) · Nature Biotechnology · doi:10.1038/74464 · Cited by 1,716 · see citing works
Self-Assembly of CdSe−ZnS Quantum Dot Bioconjugates Using an Engineered Recombinant Protein
Mattoussi, H. M., Mauro, J. M., Goldman, E. R., Anderson, G. P., Sundar, V. C., Mikulec, F. V., & Bawendi, M. G. (2000) · Journal of the American Chemical Society · doi:10.1021/ja002535y · Cited by 1,681 · see citing works
Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake
Zhang, Y., Kohler, N., & Zhang, M. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00267-8 · Cited by 1,266 · see citing works
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J. (2006) · Nano Letters · doi:10.1021/nl061412u · Cited by 1,238 · see citing works
Jun, Y., Huh, Y., Choi, J., Lee, J.-H., Song, H., Kim, S. J., Yoon, S., Kim, K., Shin, J., Suh, J., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0422155 · Cited by 1,195 · see citing works
Photochemical Instability of CdSe Nanocrystals Coated by Hydrophilic Thiols
Aldana, J., Wang, Y. A., & Peng, X. (2001) · Journal of the American Chemical Society · doi:10.1021/ja016424q · Cited by 1,108 · see citing works
Synthesis and Characterization of Nanometer-Size Fe 3 O 4 and γ-Fe 2 O 3 Particles
Kang, Y. S., Risbud, S. H., Rabolt, J. F., & Stroeve, P. (1996) · Chemistry of Materials · doi:10.1021/cm960157j · Cited by 1,068 · see citing works
Pellegrino, T., Manna, L., Kudera, S., Liedl, T., Koktysh, D. S., Rogach, A. L., Keller, S., Rädler, J. O., Natile, G., & Parak, W. J. (2004) · Nano Letters · doi:10.1021/nl035172j · Cited by 1,067 · see citing works
Self-citationSize-Sorted Anionic Iron Oxide Nanomagnets as Colloidal Mediators for Magnetic Hyperthermia
Fortin, J.-P., Wilhelm, C., Servais, J., Ménager, C., Bacri, J.-C., & Gazeau, F. (2007) · Journal of the American Chemical Society · doi:10.1021/ja067457e · Cited by 1,039 · see citing works
Bedanta, S., & Kleemann, W. (2008) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/42/1/013001 · Cited by 1,022 · see citing works
Magnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy
Hergt, R., Dutz, S., Müller, R., & Zeisberger, M. (2006) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/18/38/s26 · Cited by 977 · see citing works
Magnetic particle hyperthermia—biophysical limitations of a visionary tumour therapy
Hergt, R., & Dutz, S. (2006) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2006.10.1156 · Cited by 927 · see citing works
Multifunctional magnetic nanoparticles for targeted imaging and therapy
MCCARTHY, J., & WEISSLEDER, R. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.014 · Cited by 892 · see citing works
Synthesis, properties and perspectives of hybrid nanocrystal structures
Cozzoli, P. D., Pellegrino, T., & Manna, L. (2006) · Chemical Society Reviews · doi:10.1039/b517790c · Cited by 877 · see citing works
Self-citationFeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents
Seo, W. S., Lee, J. H., Sun, X., Suzuki, Y., Mann, D., Liu, Z., Terashima, M., Yang, P. C., McConnell, M. V., Nishimura, D. G., et al. (2006) · Nature Materials · doi:10.1038/nmat1775 · Cited by 875 · see citing works
Synthesis and Characterization of Nanometer-Size Fe3O4 and γ-Fe2O3 Particles
Kang, Y. S., Risbud, S. H., Rabolt, J. F., & Stroeve, P. (1998) · Chemistry of Materials · doi:10.1021/cm970904s · Cited by 810 · see citing works
Maier-Hauff, K., Rothe, R., Scholz, R., Gneveckow, U., Wust, P., Thiesen, B., Feussner, A., von Deimling, A., Waldöfner, N., Felix, R., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9195-0 · Cited by 772 · see citing works
Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging
Thorek, D. L. J., Chen, A. K., Czupryna, J., & Tsourkas, A. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-9002-7 · Cited by 770 · see citing works
In vivo imaging of siRNA delivery and silencing in tumors
Medarova, Z., Pham, W., Farrar, C., Petkova, V., & Moore, A. (2007) · Nature Medicine · doi:10.1038/nm1486 · Cited by 697 · see citing works
Programmed Assembly of DNA Functionalized Quantum Dots
Mitchell, G. P., Mirkin, C. A., & Letsinger, R. L. (1999) · Journal of the American Chemical Society · doi:10.1021/ja991662v · Cited by 686 · see citing works
Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications
Qiao, R., Yang, C., & Gao, M. (2009) · Journal of Materials Chemistry · doi:10.1039/b902394a · Cited by 685 · see citing works
Physical limits of hyperthermia using magnetite fine particles
Hergt, R., Andrä, W., D'ambly, C. G., Hilger, I., Kaiser, W. A., Richter, U., & Schmidt, H.-G. (1998) · IEEE Transactions on Magnetics · doi:10.1109/20.718537 · Cited by 659 · see citing works
Yu, M. K., Jeong, Y. Y., Park, J., Park, S.-J., Kim, J. W., Min, J. J., Kim, K., & Jon, S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200800857 · Cited by 613 · see citing works
Hydroxylated Quantum Dots as Luminescent Probes for in Situ Hybridization
Pathak, S., Choi, S., Arnheim, N., & Thompson, M. E. (2001) · Journal of the American Chemical Society · doi:10.1021/ja0058334 · Cited by 611 · see citing works
Lee, H., Lee, E., Kim, D. K., Jang, N. K., Jeong, Y. Y., & Jon, S. (2006) · Journal of the American Chemical Society · doi:10.1021/ja061529k · Cited by 594 · see citing works
Kohler, N., Sun, C., Wang, J., & Zhang, M. (2005) · Langmuir · doi:10.1021/la0503451 · Cited by 580 · see citing works
Pinaud, F. F., King, D., Moore, H. H., & Weiss, S. (2004) · Journal of the American Chemical Society · doi:10.1021/ja031691c · Cited by 573 · see citing works
Optical and MRI Multifunctional Nanoprobe for Targeting Gliomas
Omid Veiseh, A., Sun, C., Gunn, J., Kohler, N., Gabikian, P., Lee, D., Bhattarai, N., Ellenbogen, R. G., Sze, R. W., Hallahan, A. R., et al. (2005) · Nano Letters · doi:10.1021/nl0502569 · Cited by 564 · see citing works
Kircher, M. F., Mahmood, U., King, R. S., Weissleder, R., & Josephson, L. (2003) · PubMed · Cited by 548 · see citing works
Johannsen, M., Gneveckow, U., Thiesen, B., Taymoorian, K., Cho, C. H., Waldöfner, N., Scholz, R., Jordan, A., Loening, S. A., & Wust, P. (2006) · European Urology · doi:10.1016/j.eururo.2006.11.023 · Cited by 531 · see citing works
Au–Fe3O4 Dumbbell Nanoparticles as Dual‐Functional Probes
Xu, C., Xie, J., Ho, D. N., Wang, C., Kohler, N., Walsh, E. G., Morgan, J. R., Chin, Y. E., & Sun, S. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200704392 · Cited by 528 · see citing works
Forming Biocompatible and Nonaggregated Nanocrystals in Water Using Amphiphilic Polymers
Yu, W. W., Chang, E., Falkner, J. C., Zhang, J., Al-Somali, A. M., Sayes, C. M., Johns, J., Drezek, R. A., & Colvin, V. L. (2007) · Journal of the American Chemical Society · doi:10.1021/ja067184n · Cited by 521 · see citing works
Selvan, S. T., Patra, P. K., Ang, C. Y., & Ying, J. Y. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604245 · Cited by 507 · see citing works
Size dependence of specific power absorption of Fe3O4 particles in AC magnetic field
Ma, M., Wu, Y., Zhou, J., Sun, Y., Zhang, Y., & Gu, N. (2003) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(03)00426-8 · Cited by 498 · see citing works
Kim, J., Lee, J. E., Lee, S. H., Yu, J. H., Lee, J. H., Park, T. G., & Hyeon, T. (2008) · Advanced Materials · doi:10.1002/adma.200701726 · Cited by 494 · see citing works
CdSe−ZnS Quantum Dots as Resonance Energy Transfer Donors in a Model Protein−Protein Binding Assay
Willard, D. M., Carillo, L. L., Jung, J., et al. (2001) · Nano Letters · doi:10.1021/nl015565n · Cited by 493 · see citing works
Bifunctional Magnetic Silica Nanoparticles for Highly Efficient Human Stem Cell Labeling
Lu, C., Hung, Y., Hsiao, J., Yao, M., Chung, T.-H., Lin, Y., Wu, S., Hsu, S.-C., Liu, H., Mou, C., et al. (2006) · Nano Letters · doi:10.1021/nl0624263 · Cited by 490 · see citing works
Vascular Targeted Nanoparticles for Imaging and Treatment of Brain Tumors
Reddy, G. R., Bhojani, M. S., McConville, P., Moody, J. B., Moffat, B. A., Hall, D. E., Kim, G., Koo, Y.-E. L., Woolliscroft, M. J., Sugai, J. V., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0946 · Cited by 488 · see citing works
Kohler, N., Fryxell, G. E., & Zhang, M. (2004) · Journal of the American Chemical Society · doi:10.1021/ja049195r · Cited by 466 · see citing works
Smith, A. M., Duan, H., Rhyner, M. N., et al. (2006) · Physical Chemistry Chemical Physics · doi:10.1039/b606572b · Cited by 462 · see citing works
The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma
Jordan, A., Scholz, R., Maier-Hauff, K., van Landeghem, F. K. H., Waldoefner, N., Teichgraeber, U., Pinkernelle, J., Bruhn, H., Neumann, F., Thiesen, B., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9059-z · Cited by 459 · see citing works
Highly Luminescent Water-Soluble CdTe Quantum Dots
Wuister, S. F., Swart, I., van Driel, F., et al. (2003) · Nano Letters · doi:10.1021/nl034054t · Cited by 441 · see citing works
Porous Hollow Fe3O4 Nanoparticles for Targeted Delivery and Controlled Release of Cisplatin
Cheng, K., Peng, S., Xu, C., & Sun, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja903300f · Cited by 438 · see citing works
Piao, Y., Kim, J., Na, H. B., Kim, D., Baek, J. S., Ko, M. K., Lee, J. H., Shokouhimehr, M., & Hyeon, T. (2008) · Nature Materials · doi:10.1038/nmat2118 · Cited by 416 · see citing works
FePt@CoS2 Yolk−Shell Nanocrystals as a Potent Agent to Kill HeLa Cells
Gao, J., Liang, G., Zhang, B., Kuang, Y., Zhang, X., & Xu, B. (2007) · Journal of the American Chemical Society · doi:10.1021/ja067785e · Cited by 403 · see citing works
Gupta, A. K., & Curtis, A. S. G. (2004) · Journal of Materials Science Materials in Medicine · doi:10.1023/b:jmsm.0000021126.32934.20 · Cited by 402 · see citing works
Synthesis and biomedical applications of hollow nanostructures
An, K., & Hyeon, T. (2009) · Nano Today · doi:10.1016/j.nantod.2009.06.013 · Cited by 392 · see citing works
Dumbbell-like Au−Fe3O4 Nanoparticles for Target-Specific Platin Delivery
Xu, C., Wang, B., & Sun, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja900790v · Cited by 390 · see citing works
Near-Infrared Fluorescent Nanoparticles as Combined MR/Optical Imaging Probes
Josephson, L., Kircher, M. F., Mahmood, U., Tang, Y., & Weissleder, R. (2002) · Bioconjugate Chemistry · doi:10.1021/bc015555d · Cited by 369 · see citing works
Multifunctional Yolk−Shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent
Gao, J., Liang, G., Cheung, J. S., Pan, Y., Kuang, Y., Zhao, F., Zhang, B., Zhang, X., Wu, E. X., & Xu, B. (2008) · Journal of the American Chemical Society · doi:10.1021/ja803920b · Cited by 366 · see citing works
Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles
van Landeghem, F. K. H., Maier-Hauff, K., Jordan, A., Hoffmann, K., Gneveckow, U., Scholz, R., Thiesen, B., Brück, W., & von Deimling, A. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.044 · Cited by 354 · see citing works
Lee, J., Jun, Y., Yeon, S., et al. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200603052 · Cited by 354 · see citing works
Biocompatible Heterostructured Nanoparticles for Multimodal Biological Detection
Choi, J., Jun, Y., Yeon, S., Kim, H. C., Shin, J., & Cheon, J. (2006) · Journal of the American Chemical Society · doi:10.1021/ja066547g · Cited by 339 · see citing works
Progress in functionalization of magnetic nanoparticles for applications in biomedicine
Berry, C. C. (2009) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/42/22/224003 · Cited by 334 · see citing works
Size-dependant heating rates of iron oxide nanoparticles for magnetic fluid hyperthermia
Gonzales-Weimuller, M., Zeisberger, M., & Krishnan, K. M. (2008) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2008.12.017 · Cited by 332 · see citing works
Yang, J., Lee, C., Ko, H. J., Suh, J., Yoon, H., Lee, K., Huh, Y., & Haam, S. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200703554 · Cited by 330 · see citing works
Lee, H., Yu, M. K., Park, S.-J., Moon, S., Min, J. J., Jeong, Y. Y., Kang, H.-W., & Jon, S. (2007) · Journal of the American Chemical Society · doi:10.1021/ja072210i · Cited by 327 · see citing works
Intracellular heating of living cells through Néel relaxation of magnetic nanoparticles
Fortin, J.-P., Gazeau, F., & Wilhelm, C. (2007) · European Biophysics Journal · doi:10.1007/s00249-007-0197-4 · Cited by 320 · see citing works
Multifunctional Composite Nanoparticles: Magnetic, Luminescent, and Mesoporous
Lin, Y., Wu, S., Hung, Y., et al. (2006) · Chemistry of Materials · doi:10.1021/cm061976z · Cited by 320 · see citing works
Conjugation of DNA to Silanized Colloidal Semiconductor Nanocrystalline Quantum Dots
Parak, W. J., Gerion, D., Zanchet, D., et al. (2002) · Chemistry of Materials · doi:10.1021/cm0107878 · Cited by 320 · see citing works
Cell response to dextran-derivatised iron oxide nanoparticles post internalisation
Berry, C. C., Wells, S., Charles, S. W., Aitchison, G., & Curtis, A. S. G. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.12.046 · Cited by 313 · see citing works
Gordon, R. T., Hines, J., & Gordon, D. (1979) · Medical Hypotheses · doi:10.1016/0306-9877(79)90063-x · Cited by 311 · see citing works
Specific Targeting, Cell Sorting, and Bioimaging with Smart Magnetic Silica Core–Shell Nanomaterials
Yoon, T., Yu, K. N., Kim, E., et al. (2005) · Small · doi:10.1002/smll.200500360 · Cited by 307 · see citing works
Biomedical applications of distally controlled magnetic nanoparticles
Corchero, J. L., & Villaverde, A. (2009) · Trends in biotechnology · doi:10.1016/j.tibtech.2009.04.003 · Cited by 280 · see citing works
Itô, A., Honda, H., & Kobayashi, T. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0049-y · Cited by 275 · see citing works
Size-Controlled Synthesis of Magnetite Nanoparticles in the Presence of Polyelectrolytes
Si, S., Kotal, A., Mandal, T. K., Giri, S., Nakamura, H., & Kohara, T. (2004) · Chemistry of Materials · doi:10.1021/cm049205n · Cited by 267 · see citing works
Evaluation of iron-cobalt/ferrite core-shell nanoparticles for cancer thermotherapy
Habib, A. H., Ondeck, C. L., Chaudhary, P., et al. (2008) · Journal of Applied Physics · doi:10.1063/1.2830975 · Cited by 265 · see citing works
Jiang, J., Gu, H., Shao, H., Devlin, E., Papaefthymiou, G. C., & Ying, J. Y. (2008) · Advanced Materials · doi:10.1002/adma.200800498 · Cited by 263 · see citing works
Qu, S., Yang, H., Ren, D., Kan, S., Zou, G., Li, D., & Li, M. (1999) · Journal of Colloid and Interface Science · doi:10.1006/jcis.1999.6185 · Cited by 262 · see citing works
Ferromagnetic Colloid for Studying Magnetic Structures
Elmore, W. C. (1938) · Physical Review · doi:10.1103/physrev.54.309 · Cited by 256 · see citing works
Optimizing Magnetic Nanoparticle Design for Nanothermotherapy
Gazeau, F., Lévy, M., & Wilhelm, C. (2008) · Nanomedicine · doi:10.2217/17435889.3.6.831 · Cited by 256 · see citing works
Anderson, S. A., Glod, J. W., Arbab, A. S., Noel, M., Ashari, P., Fine, H. A., & Frank, J. A. (2004) · Blood · doi:10.1182/blood-2004-06-2222 · Cited by 254 · see citing works
Lutz, J., Stiller, S., Hoth, A., Kaufner, L., Pison, U., & Cartier, R. (2006) · Biomacromolecules · doi:10.1021/bm0607527 · Cited by 251 · see citing works
In vivo imaging of islet transplantation
Evgenov, N. V., Medarova, Z. O., Dai, G., Bonner‐Weir, S., & Moore, A. V. (2005) · Nature Medicine · doi:10.1038/nm1316 · Cited by 250 · see citing works
Bertorelle, F., Wilhelm, C., Roger, J., Gazeau, F., Ménager, C., & Cabuil, V. (2006) · Langmuir · doi:10.1021/la052710u · Cited by 211 · see citing works
Guo, W., Li, J. J., Wang, Y. A., & Peng, X. (2003) · Chemistry of Materials · doi:10.1021/cm034341y · Cited by 201 · see citing works
FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition
Xu, C., Yuan, Z., Kohler, N., Kim, J., Chung, M. A., & Sun, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja905938a · Cited by 200 · see citing works
DeNardo, S. J., DeNardo, G. L., Miers, L. A., Natarajan, A., Foreman, A. R., Gruettner, C., Adamson, G. N., & Ivkov, R. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1004-0022 · Cited by 200 · see citing works
Colloidal Strategies for Preparing Oxide‐Based Hybrid Nanocrystals
Casavola, M., Buonsanti, R., Caputo, G., & Cozzoli, P. D. (2007) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.200701047 · Cited by 191 · see citing works
Magnetically induced hyperthermia: size-dependent heating power of γ-Fe2O3 nanoparticles
Lévy, M., Wilhelm, C., Siaugue, J., et al. (2008) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/20/20/204133 · Cited by 184 · see citing works
Antitumor Immunity Induction by Intracellular Hyperthermia Using Magnetite Cationic Liposomes
Yanase, M., Shinkai, M., Honda, H., et al. (1998) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1998.tb03283.x · Cited by 183 · see citing works
Kalambur, V. S., Han, B., Hammer, B. E., et al. (2005) · Nanotechnology · doi:10.1088/0957-4484/16/8/041 · Cited by 175 · see citing works
Size-controlled preparation of magnetite nanoparticles in the presence of graft copolymers
Wan, S., Huang, J., Yan, H., et al. (2005) · Journal of Materials Chemistry · doi:10.1039/b512605c · Cited by 169 · see citing works
Bruns†, O. T., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Lauterwasser, J., Nikolić, M. S., Mollwitz†, B., Merkel, M., Bigall, N. C., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2008.405 · Cited by 165 · see citing works
Huang, C., Lo, C. ‐., Chen, H., & Hsiue, G. (2007) · Advanced Functional Materials · doi:10.1002/adfm.200600818 · Cited by 155 · see citing works
Lin, M.-M., Kim, D. K., Haj, A. E., & Dobson, J. (2008) · IEEE Transactions on Nanobioscience · doi:10.1109/tnb.2008.2011864 · Cited by 149 · see citing works
Giant Amphiphiles by Cofactor Reconstitution
Boerakker, M. J., Hannink, J. M., Bomans, P. H. H., Frederik, P. M., Nolte, R. J. M., Meijer, E. M., & Sommerdijk, N. A. J. M. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20021115)41:22 · Cited by 146 · see citing works
Design and Characterization of Lysine Cross-Linked Mercapto-Acid Biocompatible Quantum Dots
Jiang, W., Mardyani, S., Fischer, H. C., et al. (2006) · Chemistry of Materials · doi:10.1021/cm051393+ · Cited by 145 · see citing works
Itô, A., Tanaka, K., Honda, H., et al. (2003) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(03)90138-1 · Cited by 133 · see citing works
Polyvinylpyrrolidone–drug conjugate: synthesis and release mechanism
D'Souza, A. J. M., Schowen, R. L., & Topp, E. M. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.09.014 · Cited by 130 · see citing works
Superparamagnetic FePt nanoparticles as excellent MRI contrast agents
Maenosono, S., Suzuki, T., & Saita, S. (2008) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2008.01.026 · Cited by 119 · see citing works
Targeting Hyperthermia for Renal Cell Carcinoma Using Human MN Antigenspecific Magnetoliposomes
Shinkai, M., Biao, L., Honda, H., Yoshikawa, K., Shimizu, K., Saga, S., Wakabayashi, T., Yoshida, J., & Kobayashi, T. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb01070.x · Cited by 111 · see citing works
Porous Iron Oxide Based Nanorods Developed as Delivery Nanocapsules
Wu, P., Wang, W., Huang, Y., Sheu, H., Lo, Y., Tsai, T., Shieh, D., & Yeh, C. (2007) · Chemistry - A European Journal · doi:10.1002/chem.200601372 · Cited by 111 · see citing works
Quarta, A., Corato, R. D., Manna, L., Argentiere, S., Cingolani, R., Barbarella, G., & Pellegrino, T. (2008) · Journal of the American Chemical Society · doi:10.1021/ja800102v · Cited by 104 · see citing works
Self-citationFluorescent-Magnetic Hybrid Nanostructures: Preparation, Properties, and Applications in Biology
Quarta, A., Corato, R. D., Manna, L., Ragusa, A., & Pellegrino, T. (2007) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2007.908989 · Cited by 101 · see citing works
Self-citationROBINSON, D. B., Persson, H. H. J., Zeng, H., et al. (2005) · Langmuir · doi:10.1021/la047206o · Cited by 96 · see citing works
New -tuned magnetic nanoparticles for self-controlled hyperthermia
Pollert, E., Knížek, K., Maryško, M., et al. (2007) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2007.02.031 · Cited by 94 · see citing works
Liu, S., Jia, B., Qiao, R., Yang, Z. H., Yu, Z., Liu, Z., Liu, K., Shi, J., Ouyang, H., Wang, F., et al. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900143a · Cited by 89 · see citing works
Kim, D., Zeng, H., Ng, T. C., et al. (2009) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2009.07.057 · Cited by 84 · see citing works
Size Modulation of Polymeric Nanoparticles under Controlled Dynamics of Microemulsion Droplets
Munshi, N., De, T., & Maitra, A. (1997) · Journal of Colloid and Interface Science · doi:10.1006/jcis.1997.4889 · Cited by 74 · see citing works
TC‐tuned biocompatible suspension of La0.73Sr0.27MnO3 for magnetic hyperthermia
Prasad, N. K., Rathinasamy, K., Panda, D., et al. (2007) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30959 · Cited by 74 · see citing works
Kaman, O., Pollert, E., Veverka, P., et al. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/27/275610 · Cited by 73 · see citing works
Magnetic-fluorescent nanocomposites for biomedical multitasking
Cussen, S. A., Byrne, A. O., Gun’ko, Y. K., et al. (2006) · Chemical Communications · doi:10.1039/b610746j · Cited by 71 · see citing works
Tumour Cell Toxicity of Intracellular Hyperthermia Mediated by Magnetic Nanoparticles
Wilhelm, C., Fortin, J.-P., & Gazeau, F. (2007) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2007.668 · Cited by 69 · see citing works
Tang, Q., Zhang, D.-S., Cong, X.-M., Wan, M.-L., & Jin, L.-Q. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.01.038 · Cited by 66 · see citing works
Tumour cell toxicity of intracellular hyperthermia mediated by magnetic nanoparticles
C.Fortin J.-P.Gazeau F., W. (2007) · Cited by 65 · see citing works
Tb-doped iron oxide: bifunctional fluorescent and magnetic nanocrystals
Zhang, Y., Das, G. K., Xu, R. Q., et al. (2009) · Journal of Materials Chemistry · doi:10.1039/b817159a · Cited by 59 · see citing works
XXXIX.The two-staye transformation of magnetite into hematite
Welo, L. A., & Baudisch, O. (1925) · The London Edinburgh and Dublin Philosophical Magazine and Journal of Science · doi:10.1080/14786442508634751 · Cited by 48 · see citing works
Internal structure of magnetic endosomes
Rivière, C., Wilhelm, C., Cousin, F., et al. (2007) · The European Physical Journal E · doi:10.1140/epje/e2007-00014-1 · Cited by 43 · see citing works
Ricketts, C. R., Cox, J. S. G., FITZMAURICE, C., et al. (1965) · Nature · doi:10.1038/208237a0 · Cited by 40 · see citing works
Huang, H., Xie, Q., Kang, M., Zhang, B., Zhang, H., Chen, J., Zhai, C., Yang, D., Jiang, B., & Wu, Y. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/36/365101 · Cited by 38 · see citing works
Structure of cytochrome c at the interface with magnetic CoFe2O4 nanoparticles
Aubin‐Tam, M., Zhou, H. H., & Hamad‐Schifferli, K. (2008) · Soft Matter · doi:10.1039/b711937b · Cited by 25 · see citing works
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Ferrite-based magnetic nanofluids used in hyperthermia applications
Sharifi, I., Shokrollahi, H., & Amiri, S. (2012) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2011.10.017 · Cited by 759 · see citing works
Guardia, P., Di Corato, R., Lartigue, L., Wilhelm, C., Espinosa, A., Garcia-Hernandez, M., Gazeau, F., Manna, L., & Pellegrino, T. (2012) · ACS Nano · doi:10.1021/nn2048137 · Cited by 752 · see citing works
Self-citation
- Authors
- Figuerola, A., Di Corato, R., Manna, L., & Pellegrino, T.
- Affiliations
- Italian Institute of Technology (IT)
- Corresponding author
- Pellegrino, Teresa
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 62
- Issue
- 2
- Pages
- 126-143
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2024633789
- Cited by
- 480
- References
- 127
- Citations by year
- 2026: 3 · 2025: 17 · 2024: 20 · 2023: 20 · 2022: 20 · 2021: 29 · 2020: 17 · 2019: 34 · 2018: 28 · 2017: 41 · 2016: 36 · 2015: 31 · 2014: 56 · 2013: 43 · 2012: 47
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- iron oxide nanoparticles, biomedical applications, magnetic nanoparticles, nanocrystals, diagnostic agents, therapeutic agents, nanoparticle synthesis
- MeSH terms
- Animals, Ferric Compounds, Humans, Nanotechnology, Nanostructures, Nanomedicine
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