Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles
Abstract
Cytotoxicity of CdSe and CdSe/ZnS nanoparticles has been investigated for different surface modifications such as coating with mercaptopropionic acid, silanization, and polymer coating. For all cases, quantitative values for the onset of cytotoxic effects in serum-free culture media are given. These values are correlated with microscope images in which the uptake of the particles by the cells has been investigated. Our data suggest that in addition to the release of toxic Cd(2+) ions from the particles also their surface chemistry, in particular their stability toward aggregation, plays an important role for cytotoxic effects. Additional patch clamp experiments investigate effects of the particles on currents through ion channels.
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- Authors
- Kirchner, C., Liedl, T., Kudera, S., Pellegrino, T., Muñoz Javier, A., Gaub, H. E., Stölzle, S., Fertig, N., & Parak, W. J.
- Affiliations
- Center for NanoScience (DE)
- Center for Nanoscience, Ludwig Maximilians Universität München, Germany, Nanion Technologies GmbH, Pettenkoferstr. 12, 80336 Munich, Germany
- Corresponding author
- Parak, Wolfgang J.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-12-31
- Volume
- 5
- Issue
- 2
- Pages
- 331-338
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2118685639
- Cited by
- 1,619
- References
- 36
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 31 · 2023: 31 · 2022: 40 · 2021: 58 · 2020: 43 · 2019: 57 · 2018: 64 · 2017: 73 · 2016: 92 · 2015: 81 · 2014: 123 · 2013: 126 · 2012: 145
- FWCI
- 28.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- CdSe nanoparticles, CdSe/ZnS core-shell nanoparticles, cytotoxicity, surface modification, silanization, polymer coatings, nanoparticle aggregation, nanoparticle uptake by cells, ion channel currents, semiconductor quantum dots
- MeSH terms
- Animals, Biocompatible Materials, Breast Neoplasms, Cell Adhesion, Cell Line, Cell Survival, Colloids, Cricetulus, Dose-Response Relationship, Drug, Fibroblasts, Cricetinae, Materials Testing, Risk Factors, Sulfides, CHO Cells, Zinc Compounds, Selenium Compounds, Risk Assessment, Cadmium Compounds, Nanotubes
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