Cited by 1,619Quantum Dots Synthesis And PropertiesNanoparticles: synthesis and applicationsHeavy Metal Exposure and Toxicity

Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles

Kirchner, Christian, Liedl, Tim, Kudera, Stefan, Pellegrino, Teresa, Muñoz Javier, Almudena, Gaub, Hermann E., Stölzle, Sonja, Fertig, N. +1 more·2005·Nano Letters

Abstract

Cytotoxicity of CdSe and CdSe/ZnS nanoparticles has been investigated for different surface modifications such as coating with mercaptopropionic acid, silanization, and polymer coating. For all cases, quantitative values for the onset of cytotoxic effects in serum-free culture media are given. These values are correlated with microscope images in which the uptake of the particles by the cells has been investigated. Our data suggest that in addition to the release of toxic Cd(2+) ions from the particles also their surface chemistry, in particular their stability toward aggregation, plays an important role for cytotoxic effects. Additional patch clamp experiments investigate effects of the particles on currents through ion channels.

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Crossref · 10.1021/nl047996m

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Authors
Kirchner, C., Liedl, T., Kudera, S., Pellegrino, T., Muñoz Javier, A., Gaub, H. E., Stölzle, S., Fertig, N., & Parak, W. J.
Affiliations
  • Center for NanoScience (DE)
  • Center for Nanoscience, Ludwig Maximilians Universität München, Germany, Nanion Technologies GmbH, Pettenkoferstr. 12, 80336 Munich, Germany
Corresponding author
Parak, Wolfgang J.
Venue
Nano Letters
Published
2004-12-31
Volume
5
Issue
2
Pages
331-338
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
OpenAlex
W2118685639
Cited by
1,619
References
36
Citations by year
2026: 18 · 2025: 21 · 2024: 31 · 2023: 31 · 2022: 40 · 2021: 58 · 2020: 43 · 2019: 57 · 2018: 64 · 2017: 73 · 2016: 92 · 2015: 81 · 2014: 123 · 2013: 126 · 2012: 145
FWCI
28.28
Type
journal article
Language
en
Open access
closed
Locations
  • Nano Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
CdSe nanoparticles, CdSe/ZnS core-shell nanoparticles, cytotoxicity, surface modification, silanization, polymer coatings, nanoparticle aggregation, nanoparticle uptake by cells, ion channel currents, semiconductor quantum dots
MeSH terms
Animals, Biocompatible Materials, Breast Neoplasms, Cell Adhesion, Cell Line, Cell Survival, Colloids, Cricetulus, Dose-Response Relationship, Drug, Fibroblasts, Cricetinae, Materials Testing, Risk Factors, Sulfides, CHO Cells, Zinc Compounds, Selenium Compounds, Risk Assessment, Cadmium Compounds, Nanotubes

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