The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Synthesis and Characterization of Biocompatible and Size-Tunable Multifunctional Porous Silica Nanoparticles
Abstract
In this work, size-controlled multifunctional mesoporous silica nanoparticles having large surface areas, embedded luminescence, high magnetization, and excellent aqueous dispersity have been successfully prepared by using a simple one-pot synthesis. The size and pore ordering of these particles can be easily controlled based on the number density of Fe 3 O 4 nanoparticle nucleation sites introduced during the silica condensation reaction. Dissolution of the embedded Fe 3 O 4 nanoparticles yields hollow mesoporous silica nanoparticles as well. These multifunctional porous nanoparticles were characterized by transmission electron microscopy, X-ray diffraction, nitrogen adsorption−desorption behavior, dynamic light scattering, zeta potential, magnetic susceptibility, and photoluminescence. Furthermore, in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) and hemolysis assays were performed to evaluate any unintended cytotoxicity. The biocompatibility of the multifunctional nanoparticles, even at very high doses, ensures their potential in biomedical applications.
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Cites
Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism
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Size-Controlled Synthesis of Magnetite Nanoparticles
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Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
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Mesoporous silica nanoparticles deliver DNA and chemicals into plants
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A General Method To Coat Colloidal Particles with Silica
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Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998
Zhao, Y., Sun, X., Zhang, G., Trewyn, B. G., Slowing, I. I., & Lin, V. S.-Y. (2011) · ACS Nano · doi:10.1021/nn103077k · Cited by 572
Biocompatibility of Mesoporous Silica Nanoparticles
Asefa, T., & Tao, Z. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300166u · Cited by 422
Metadata
- Authors
- Lin, Y.-S., & Haynes, C. L.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-08-12
- Volume
- 21
- Issue
- 17
- Pages
- 3979-3986
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2001168539
- Cited by
- 364
- References
- 31
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- closed
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