The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Synthesis and Characterization of Biocompatible and Size-Tunable Multifunctional Porous Silica Nanoparticles
Abstract
In this work, size-controlled multifunctional mesoporous silica nanoparticles having large surface areas, embedded luminescence, high magnetization, and excellent aqueous dispersity have been successfully prepared by using a simple one-pot synthesis. The size and pore ordering of these particles can be easily controlled based on the number density of Fe 3 O 4 nanoparticle nucleation sites introduced during the silica condensation reaction. Dissolution of the embedded Fe 3 O 4 nanoparticles yields hollow mesoporous silica nanoparticles as well. These multifunctional porous nanoparticles were characterized by transmission electron microscopy, X-ray diffraction, nitrogen adsorption−desorption behavior, dynamic light scattering, zeta potential, magnetic susceptibility, and photoluminescence. Furthermore, in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) and hemolysis assays were performed to evaluate any unintended cytotoxicity. The biocompatibility of the multifunctional nanoparticles, even at very high doses, ensures their potential in biomedical applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism
Kresge, C. T., Leonowicz, M. E., Roth, W. J., Vartuli, J. C., & Beck, J. S. (1992) · Nature · doi:10.1038/359710a0 · Cited by 16,275
Size-Controlled Synthesis of Magnetite Nanoparticles
Sun, S., & Zeng, H. (2002) · Journal of the American Chemical Society · doi:10.1021/ja026501x · Cited by 2,829
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
Liong, M., Lu, J., Kovochich, M., Xia, T., Ruehm, S. G., Nel, A. E., Tamanoi, F., & Zink, J. I. (2008) · ACS Nano · doi:10.1021/nn800072t · Cited by 1,929
Deng, Y., Qi, D., Deng, C., Zhang, X., & Zhao, D. (2008) · Journal of the American Chemical Society · doi:10.1021/ja0777584 · Cited by 1,673
Mesoporous silica nanoparticles deliver DNA and chemicals into plants
Torney, F., Trewyn, B. G., Lin, V. S.-Y., & Wang, K. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.108 · Cited by 1,481
Kim, J., Kim, H. S., Lee, N., Kim, T., Kim, H., Yu, T., Song, I. C., Moon, W. K., & Hyeon, T. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200802469 · Cited by 1,220
A General Method To Coat Colloidal Particles with Silica
Graf, C., Vossen, D. L. J., Imhof, A., & van Blaaderen, A. (2003) · Langmuir · doi:10.1021/la0347859 · Cited by 1,175
Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs
Lu, J., Liong, M., Zink, J. I., & Tamanoi, F. (2007) · Small · doi:10.1002/smll.200700005 · Cited by 1,012
Giri, S., Trewyn, B. G., Stellmaker, M. P., & Lin, V. S. ‐. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501819 · Cited by 997
Kim, J., Lee, J. E., Lee, J., Yu, J. H., Kim, B. C., An, K., Hwang, Y., Shin, C.-H., Park, J.-G., Kim, J., et al. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0565875 · Cited by 876
Mesoporous Silica Nanoparticles for Intracellular Delivery of Membrane-Impermeable Proteins
Slowing, I. I., Trewyn, B. G., & Lin, V. S.-Y. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0719780 · Cited by 795
Zhao, W., Gu, J., Zhang, L., Chen, H., & Shi, J. (2005) · Journal of the American Chemical Society · doi:10.1021/ja051113r · Cited by 762
Method for Analysis of Nanoparticle Hemolytic Properties in Vitro
Dobrovolskaia, M. A., Clogston, J. D., Neun, B. W., Hall, J. B., Patri, A. K., & McNeil, S. E. (2008) · Nano Letters · doi:10.1021/nl0805615 · Cited by 716
Dilute Solution Routes to Various Controllable Morphologies of MCM-41 Silica with a Basic Medium
Cai, Q., Luo, Z.-S., Pang, W.-Q., Fan, Y.-W., Chen, X.-H., & Cui, F.-Z. (2001) · Chemistry of Materials · doi:10.1021/cm990661z · Cited by 679
Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells
Slowing, I. I., Wu, C., Vivero‐Escoto, J. L., & Lin, V. S. ‐. (2009) · Small · doi:10.1002/smll.200800926 · Cited by 527
Kim, J., Lee, J. E., Lee, S. H., Yu, J. H., Lee, J. H., Park, T. G., & Hyeon, T. (2008) · Advanced Materials · doi:10.1002/adma.200701726 · Cited by 494
Mesoporous Silica Nanospheres as Highly Efficient MRI Contrast Agents
Taylor, K. M. L., Kim, J. S., Rieter, W. J., An, H., Lin, W., & Lin, W. (2008) · Journal of the American Chemical Society · doi:10.1021/ja710193c · Cited by 458
Well-Ordered Mesoporous Silica Nanoparticles as Cell Markers
Lin, Y.-S., Tsai, C.-P., Huang, H.-Y., Kuo, C.-T., Hung, Y., Huang, D.-M., Chen, Y.-C., & Mou, C.-Y. (2005) · Chemistry of Materials · doi:10.1021/cm051014c · Cited by 424
Self-citationSuzuki, K., Ikari, K., & Imai, H. (2004) · Journal of the American Chemical Society · doi:10.1021/ja038250d · Cited by 375
Lee, J., Jun, Y., Yeon, S., Shin, J., & Cheon, J. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200603052 · Cited by 354
In Vivo Study of Biodistribution and Urinary Excretion of Surface-Modified Silica Nanoparticles
He, X., Nie, H., Wang, K., Tan, W., Wu, X., & Zhang, P. (2008) · Analytical Chemistry · doi:10.1021/ac801882g · Cited by 348
Yang, J., Lee, C., Ko, H., Suh, J., Yoon, H., Lee, K., Huh, Y., & Haam, S. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200703554 · Cited by 331
Multifunctional Composite Nanoparticles: Magnetic, Luminescent, and Mesoporous
Lin, Y.-S., Wu, S.-H., Hung, Y., Chou, Y.-H., Chang, C., Lin, M.-L., Tsai, C.-P., & Mou, C.-Y. (2006) · Chemistry of Materials · doi:10.1021/cm061976z · Cited by 320
Self-citationNear-infrared optical imaging of epidermal growth factor receptor in breast cancer xenografts.
Shi, K., Wen, X., Gurfinkel, M., Charnsangavej, C., Wallace, S., Sevick-Muraca, E. M., & Li, C. (2003) · PubMed · Cited by 270
Hollow Silica Nanocontainers as Drug Delivery Vehicles
Yang, J., Lee, J., Kang, J., Lee, K., Suh, J.-S., Yoon, H.-G., Huh, Y.-M., & Haam, S. (2008) · Langmuir · doi:10.1021/la701688t · Cited by 240
Wu, S., Lin, Y., Hung, Y., Chou, Y., Hsu, Y., Chang, C., & Mou, C. (2008) · ChemBioChem · doi:10.1002/cbic.200700509 · Cited by 209
Self-citationA Fast and Efficient Ion-Exchange Procedure To Remove Surfactant Molecules from MCM-41 Materials
Lang, N., & Tuel, A. (2004) · Chemistry of Materials · doi:10.1021/cm030633n · Cited by 175
Blood Compatibility of Cetyl Alcohol/Polysorbate-Based Nanoparticles
Koziara, J. M., Oh, J. J., Akers, W. S., Ferraris, S. P., & Mumper, R. J. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-7547-7 · Cited by 125
Lim, J., Eggeman, A. S., Lanni, F., et al. (2008) · Advanced Materials · doi:10.1002/adma.200702196 · Cited by 111
Surface Modification of Silica Core−Shell Nanocapsules: Biomedical Implications
Jovanovic, A. V., Flint, J. A., Varshney, M., Morey, T. E., Dennis, D. M., & Duran, R. S. (2006) · Biomacromolecules · doi:10.1021/bm050820+ · Cited by 43
Plasmonic Magnetic Nanostructure for Bimodal Imaging and Photonic‐Based Therapy of Cancer Cells
Lim, Y. T., Cho, M. Y., Kim, J. K., et al. (2007) · ChemBioChem · doi:10.1002/cbic.200700416 · Cited by 40
Cited by
Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998
Zhao, Y., Sun, X., Zhang, G., Trewyn, B. G., Slowing, I. I., & Lin, V. S.-Y. (2011) · ACS Nano · doi:10.1021/nn103077k · Cited by 572
Biocompatibility of Mesoporous Silica Nanoparticles
Asefa, T., & Tao, Z. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300166u · Cited by 422
Metadata
- Authors
- Lin, Y.-S., & Haynes, C. L.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-08-12
- Volume
- 21
- Issue
- 17
- Pages
- 3979-3986
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2001168539
- Cited by
- 364
- References
- 31
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
