Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft

Toxicity of human hemoglobin solution infused into rabbits.

Ct, W., Murray, A. J., Greene, J. R., Smith, D. J., Medina, F., MAKOVEC, G. T., Ej, M., & Bolin, R. B. (1986) · PubMed · Cited by 51

Diffusion Coefficients of Respiratory Gases in a Perfluorocarbon Liquid

O'Brien, R. N., Andre, J. L., & Seufert, W. D. (1982) · Science · doi:10.1126/science.6806902 · Cited by 50

Hemoglobin infusion augments the tumor necrosis factor response to bacterial endotoxin (lipopolysaccharide) in mice

Su, D., Roth, R. I., & Levin, J. (1999) · Critical Care Medicine · doi:10.1097/00003246-199904000-00034 · Cited by 50

A quantitative description in three dimensions of oxygen uptake by human red blood cells

Vandegriff, K. D., & Olson, J. S. (1984) · Biophysical Journal · doi:10.1016/s0006-3495(84)84226-5 · Cited by 49

Permeability characteristics of hemoglobin derivatives across cultured endothelial cell monolayers

Nakai, K., Sakuma, I., Ohta, T., et al. (1998) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(98)90045-2 · Cited by 49

Ring versus straight chain perfluorocarbon emulsions for perfusion media

CLARKJR, L., Wesseler, E. P., MILLER, M., & Kaplan, S. (1974) · Microvascular Research · doi:10.1016/s0026-2862(74)80007-5 · Cited by 49

Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat.

Heneka, M. T., Löschmann, P.-A., & Oßwald, H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119132 · Cited by 49

Transfusion practice should be audited for both undertransfusion and overtransfusion

Lenfant, C. (1992) · Transfusion · doi:10.1046/j.1537-2995.1992.32993110764.x · Cited by 49

THE PRESENCE OF LIPOSOMAL MATERIAL IN PHOSPHATIDE STABILIZED EMULSIONS

Groves, M. J., Wineberg, M., & Brain, A. P. R. (1985) · Journal of Dispersion Science and Technology · doi:10.1080/01932698508943947 · Cited by 49

Oxygen Delivery Augmentation by Low-Dose Perfluorochemical Emulsion During Profound Normovolemic Hemodilution

Keipert, P. E., Faithfull, N. S., Bradley, J. D., Hazard, D. Y., Hogan, J., Levisetti, M. S., & Peters, R. M. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2468-7_26 · Cited by 48

Perfluorocarbon-Based Red Blood Cell Substitutes

Biro, G. P. (1993) · Transfusion Medicine Reviews · doi:10.1016/s0887-7963(93)70127-3 · Cited by 48

Hemoglobin-based blood substitutes and the hazards of blood radicals

Alayash, A. I. (2000) · Free Radical Research · doi:10.1080/10715760000300881 · Cited by 48

A Mutation That Improves Soluble Recombinant Hemoglobin Accumulation in Escherichia coli in Heme Excess

Weickert, M. J., Pagratis, M., Glascock, C. B., & Blackmore, R. S. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.2.640-647.1999 · Cited by 48

Rational Approaches to Chemotherapy: Antisickling Agents

Klotz, I. M., Haney, D. N., & King, L. C. (1981) · Science · doi:10.1126/science.7256275 · Cited by 47

The electrochemical fluorination of organic compounds: Further data in support of the ECbECn mechanism

Gambaretto, G. P., Napoli, M., Conte, L., Scipioni, A., & Armelli, R. (1985) · Journal of Fluorine Chemistry · doi:10.1016/s0022-1139(00)84984-2 · Cited by 47

Nitric oxide and hemoglobin interactions in the vasculature

Kosaka, H. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00026-2 · Cited by 47

The effect of stabilising agents on the organ distribution of lipid emulsions

Illum, L., West, P., Washington, C., & Davis, S. S. (1989) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(89)90163-4 · Cited by 47

Liposome-Encapsulated Hemoglobin: Oxygen Binding Properties and Respiratory Function

Farmer, M. C., Rudolph, A. S., Vandegriff, K. D., Hayre, M. D., Bayne, S., & Johnson, S. A. (1988) · Biomaterials Artificial Cells and Artificial Organs · doi:10.3109/10731198809132578 · Cited by 47

Mechanisms of the adjuvant effect of hemoglobin in experimental peritonitis. V. The significance of the coordinated iron component.

Lee, J. T., Dh, A., Rd, N., & Simmons, R. L. (1979) · PubMed · Cited by 47

Epidemiology of red blood cell utilization

Vamvakas, E. C. (1996) · Transfusion Medicine Reviews · doi:10.1016/s0887-7963(96)80122-2 · Cited by 46

Protein Engineering Strategies for Designing More Stable Hemoglobin-based Blood Substitutes

Olson, J. S., Eich, R. F., Smith, L. P., Warren, J. J., & Knowles, B. C. (1997) · Artificial Cells Blood Substitutes and Biotechnology · doi:10.3109/10731199709118912 · Cited by 46

Role of the Perfluorocarbon Fluosal-DA in Coronary Angioplasty

Kerins, D. M. (1994) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199403000-00009 · Cited by 46

Diaspirin Cross-Linked Hemoglobin Is Efficacious in Gut Resuscitation as Measured by a GI Tract Optode

Frankel, H. L., Nguyen, H. B., Shea‐Donohue, T., et al. (1996) · doi:10.1097/00005373-199602000-00010 · Cited by 45

Intestinal ischemia: Reduction of mortality utilizing intraluminal perfluorochemical

Riccl, J. L., Slovlter, H. A., & Zlegler, M. M. (1985) · The American Journal of Surgery · doi:10.1016/s0002-9610(85)80014-3 · Cited by 45

Nitric oxide in mucosal immunity

Green, S. J. (1995) · Nature Medicine · doi:10.1038/nm0695-515 · Cited by 45

Effect of human hemoglobin on systemic and regional hemodynamics in a porcine model of endotoxemic shock

Aranow, J. S., Wang, H., Zhuang, J., & Fink, M. P. (1996) · Critical Care Medicine · doi:10.1097/00003246-199605000-00014 · Cited by 45

Peroxynitrite Induces Long-Lived Tyrosyl Radical(s) in Oxyhemoglobin of Red Blood Cells through a Reaction Involving CO2 and a Ferryl Species

Minetti, M., Scorza, G., & Pietraforte, D. (1999) · Biochemistry · doi:10.1021/bi982311g · Cited by 44

Treatment of intestinal ischemia with oxygenated intraluminal perfluorocarbons

Oldham, K. T., Guice, K. S., Gore, D. C., Gourley, W. K., & Lobe, T. E. (1987) · The American Journal of Surgery · doi:10.1016/0002-9610(87)90606-4 · Cited by 44

Recombinant human sickle hemoglobin expressed in yeast.

de Llano, J. J. M., Schneewind, O., Stetler, G. L., & Manning, J. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.918 · Cited by 44

Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments

Rudolph, A. S., Sulpizio, A. C., Hieble, P., Macdonald, V. W., Chavez, M. D., & Feuerstein, G. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.6.1826 · Cited by 44

Perceptions and preferences of autologous blood donors

Lee, S. J., Liljas, B., Churchill, W. H., Popovsky, M. A., Stowell, C. P., Cannon, M. E., & Johannesson, M. (1998) · Transfusion · doi:10.1046/j.1537-2995.1998.38898375515.x · Cited by 43

Alternative aspirins as antisickling agents: acetyl-3,5-dibromosalicylic acid.

Walder, J. A., Zaugg, R. H., Iwaoka, R. S., Watkin, W. G., & Klotz, I. M. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5499 · Cited by 43

Consequences of chemical modifications on the free radical reactions of human hemoglobin

Alayash, A. I., Fratantoni, J. C., Bonaventura, C., Bonaventura, J., & Bucci, E. M. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90101-2 · Cited by 43

Development of a Perfluorochemical Emulsion as a Blood Gas Carrier

MITSUNO, T., Ohyanagi, H., & Yokoyama, K. (1984) · Artificial Organs · doi:10.1111/j.1525-1594.1984.tb04240.x · Cited by 43

Differential susceptibilities of the prosthetic heme of hemoglobin-based red cell substitutes

Osawa, Y., Darbyshire, J. F., Meyer, C. A., & Alayash, A. I. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90621-3 · Cited by 42

Synthesis and Assembly of Poly(ethylene glycol)−Lipids with Mono-, Di-, and Tetraacyl Chains and a Poly(ethylene glycol) Chain of Various Molecular Weights

Takeoka, S., Mori, K., Ohkawa, H., Sou, K., & Tsuchida, E. (2000) · Journal of the American Chemical Society · doi:10.1021/ja000835+ · Cited by 42

How Allosteric Effectors Can Bind to the Same Protein Residue and Produce Opposite Shifts in the Allosteric Equilibrium

Abraham, D. J., Safo, M. K., Boyiri, T., Danso-Danquah, R. E., KISTER, J., & Poyart, C. (1995) · Biochemistry · doi:10.1021/bi00046a007 · Cited by 42

A physicochemical evaluation of perfluorochemicals for oxygen transport applications

Weers, J. G. (1993) · Journal of Fluorine Chemistry · doi:10.1016/s0022-1139(00)80064-0 · Cited by 42

Chemical modification of hemoglobins: a study of conformation restraint by internal bridging.

Simon, S. R., & Konigsberg, W. H. (1966) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.56.2.749 · Cited by 42

Absence of Hemoprotein-Associated Free Radical Events Following Oxidant Challenge of Crosslinked Hemoglobin–Superoxide Dismutase Catalase

D’Agnillo, F., & Chang, T. M. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00374-2 · Cited by 42

Novel Cosmetic Delivery Systems

Reilly, W. J. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00255-8 · Cited by 42

Electrochemical Fluorination and Its Applications

Alsmeyer, Y. W., Childs, W., Flynn, R. M., Moore, G. G. I., & Smeltzer, J. C. (1994) · Springer eBooks · doi:10.1007/978-1-4899-1202-2_5 · Cited by 41

[5] Purification of glycated hemoglobin

Cohen, M. P., & Wu, V.-Y. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)31007-6 · Cited by 41

Lipid peroxidation in hemoglobin-containing liposomes. Effects of membrane phospholipid composition and cholesterol content

Szebeni, J., & Toth, K. (1986) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(86)90341-x · Cited by 41

Experimental study of new cerebral protective substances ? functional recovery of severe, incomplete ischaemic brain lesions pretreated with mannitol and fluorocarbon emulsion

Mizoi, K., Yoshimoto, T., & Suzuki, J. (1981) · Acta Neurochirurgica · doi:10.1007/bf01407227 · Cited by 41

Prolonged myocardial contrast echocardiography via peripheral venous administration of QW3600 Injection (EchoGen®): Its efficacy and side effects

Beppu, S., Matsuda, H., Shishido, T., Matsumura, M., & Miyatake, K. (1997) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(97)80028-4 · Cited by 41

Phase I Trial to Determine the Safety, Pharmacodynamics, and Pharmacokinetics of RSR13, a Novel Radioenhancer, in Newly Diagnosed Glioblastoma Multiforme

Kleinberg, L. R., Grossman, S. A., Piantadosi, S., Pearlman, J. L., Engelhard, H. H., Lesser, G. J., Ruffer, J. E., & Gerber, M. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.8.2593 · Cited by 40

Generation of toxic phospholipid(s) during oxyhemoglobin-induced peroxidation of phosphatidylcholines

Itabe, H., Kobayashi, T., & Keizo, I. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90125-7 · Cited by 40

Effect of supplemental perfluorocarbon administration on hypotensive resuscitation of severe uncontrolled hemorrhage

Stern, S. A., Dronen, S. C., McGoron, A. J., Wang, X., Chaffins, K., Millard, R. W., Keipert, P. E., & Faithfull, N. S. (1995) · The American Journal of Emergency Medicine · doi:10.1016/0735-6757(95)90198-1 · Cited by 40

Chloride ion independence of the Bohr effect in a mutant human hemoglobin beta (V1M+H2deleted).

Fronticelli, C., Pechik, I. V., Brinigar, W. S., Kowalczyk, J. S., & Gilliland, G. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51032-8 · Cited by 39

Autoxidation of Pyridoxalated Hemoglobin Polyoxyethylene Conjugate

Talarico, T. L., Swank, A., & Privalle, C. T. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9312 · Cited by 39

Hemodynamic effects of different preparations of stroma free hemolysates in the isolated perfused rat kidney

Lieberthal, W., Wolf, E. F., Merrill, E. W., Levinsky, N. G., & VALERI, C. R. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90437-1 · Cited by 38

Detrimental effect of excess lecithin on the stability of fluorocarbon/lecithin emulsions

Krafft, M. P., Rolland, J. P., & Riess, J. G. (1991) · The Journal of Physical Chemistry · doi:10.1021/j100167a054 · Cited by 38

THE EFFECTS OF DIASPIRIN CROSS-LINKED HEMOGLOBIN IN SEPSIS

Mourelatos, M. G., Enzer, N., Ferguson, J. L., et al. (1996) · Shock · doi:10.1097/00024382-199602000-00010 · Cited by 38

Liver and Kidney Injury After Administration of Hemoglobin Cross-Linked with Bis(3,5-Dibromosalicyl) Fumarate

Smith, C. D., Schuschereba, S. T., Hess, J. R., McKinney, L., Bunch, D., & Bowman, P. D. (1990) · Biomaterials Artificial Cells and Artificial Organs · doi:10.3109/10731199009117305 · Cited by 38

Beneficial long-term effect of intracoronary perfluorochemical on infarct size and ventricular function in a canine reperfusion model

Forman, M. B., Puett, D. W., Wilson, B. H., Vaughn, W. K., Friesinger, G. C., & Virmani, R. (1987) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(87)80311-x · Cited by 37

Preparation, properties, and plasma retention of human hemoglobin derivatives: comparison of uncrosslinked carboxymethylated hemoglobin with crosslinked tetrameric hemoglobin.

Manning, L. R., Morgan, S., Beavis, R. C., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3329 · Cited by 37

Bisaldehyde Allosteric Effectors as Molecular Ratchets and Probes

Boyiri, T., Safo, M. K., Danso-Danquah, R. E., KISTER, J., Poyart, C., & Abraham, D. J. (1995) · Biochemistry · doi:10.1021/bi00046a008 · Cited by 37

Modification of cerebral ischemia with Fluosol.

Peerless, S. J., Nakamura, R., Rodriguez-Salazar, A., & Hunter, I. G. (1985) · Stroke · doi:10.1161/01.str.16.1.38 · Cited by 37

Generation of Free Oxygen Radicals and the Toxicity of Hemoglobin Solutions

Simoni, J., Feola, M., & Canizaro, P. C. (1990) · Biomaterials Artificial Cells and Artificial Organs · doi:10.3109/10731199009117301 · Cited by 37

Partial liquid ventilation improves gas exchange and increases EELV in acute lung injury

Gauger, P. G., Overbeck, M. C., Chambers, S. D., Cailipan, C. I., & Hirschl, R. B. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.5.1566 · Cited by 37

A NEW CONCEPT IN THE STABILIZATION OF INJECTABLE FLUOROCARBON EMULSIONS: THE USE OF MIXED FLUOROCARBON-HYDROCARBON DOWELS.

Riess, J. G., Solé-Violan, L., & Postel, M. (1992) · Journal of Dispersion Science and Technology · doi:10.1080/01932699208943319 · Cited by 36

Conformational Fluctuations in Deoxy Hemoglobin Revealed as a Major Contributor to Anionic Modulation of Function through Studies of the Oxygenation and Oxidation of Hemoglobins A0 and Deer Lodge β2(NA2)His → Arg

Bonaventura, C., Tesh, S., Faulkner, K. M., et al. (1998) · Biochemistry · doi:10.1021/bi971574s · Cited by 36

A new therapeutic method for acute brain infarction: Revascularization following the administration of mannitol and perfluorochemicals—A preliminary report

Suzuki, J., Yoshimoto, T., Kodama, N., Sakurai, Y., & Ogawa, A. (1982) · Surgical Neurology · doi:10.1016/0090-3019(82)90301-9 · Cited by 36

Supporting Tissue Oxygenation During Acute Surgical Bleeding Using A Perfluorochemical-Based Oxygen Carrier

Keipert, P. E., Faithfull, N. S., Roth, D. J., Bradley, J. D., Batra, S., Jochelson, P., & Flaim, K. E. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0333-6_77 · Cited by 35

Modification of hemoglobin with analogs of aspirin.

Zaugg, R. H., Walder, J. A., Walder, R. Y., Steele, J. M., & Klotz, I. M. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85812-x · Cited by 35

The Impact of Polyethylene Glycol Conjugation on Bovine Hemoglobin's Circulatory Half‐Life and Renal Effects in a Rabbit Top‐Loaded Transfusion Model

Conover, C. D., Gilbert, C. W., Shurn, K. L., & Shorr, R. (1997) · Artificial Organs · doi:10.1111/j.1525-1594.1997.tb00250.x · Cited by 35

Engineering and design of blood substitutes

Sanders, K., Ackers, G., & Sligar, S. (1996) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(96)80120-5 · Cited by 35

Metabolic and functional effects of perfluorocarbon distal perfusion during coronary angioplasty

Young, L. H., Jaffe, C. C., Revkin, J. H., McNulty, P. H., & CLEMAN, M. W. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)91001-m · Cited by 35

Lack of complications in long-term survivors after treatment with fluosolR and oxygen as an adjuvant to radiation therapy for high-grade brain tumors

Evans, R. G., Kimler, B. F., Morantz, R. A., & Batnitzky, S. (1993) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(93)90283-2 · Cited by 35

Effect of Polyethylene Glycol Conjugated Bovine Hemoglobin in Both Top‐Load and Exchange Transfusion Rat Models

Conover, C. D., Linberg, R., Gilbert, C. W., Shum, K. L., & Shorr, R. (1997) · Artificial Organs · doi:10.1111/j.1525-1594.1997.tb00444.x · Cited by 35

Coronary Vasoconstrictor Activity of Purified and Modified Human Hemoglobin

Macdonald, V. W., Winslow, R. M., Marini, M., & Klinker, M. T. (1990) · Biomaterials Artificial Cells and Artificial Organs · doi:10.3109/10731199009117306 · Cited by 35

[27] Transgenic swine as a recombinant production system for human hemoglobin

Logan, J. S., & Martin, M. J. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)31029-7 · Cited by 34

The effect of altered hemoglobin-oxygen affinity on oxygen transport by hemoglobin solution

Gould, S. A., Rosen, A. L., Sehgal, L. R., et al. (1980) · Journal of Surgical Research · doi:10.1016/0022-4804(80)90123-7 · Cited by 34

Hemoglobin: A Lifesaver and an Oxidant how to tip the Balance

Faassen, A. E., Sundby, S. R., Panter, S. S., Condie, R. M., & Hedlund, B. E. (1988) · Biomaterials Artificial Cells and Artificial Organs · doi:10.3109/10731198809132559 · Cited by 34

Increased plasma O2 solubility improves O2 uptake of in situ dog muscle working maximally

Hogan, M. C., Willford, D. C., Keipert, P. E., et al. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.6.2470 · Cited by 34

Fluid Fluorocarbon as Oxygenator in Experimental Extracorporeal Circulation

Howlett, S. A., Dundas, D., & Sabiston, D. C. (1965) · Archives of Surgery · doi:10.1001/archsurg.1965.01320160097023 · Cited by 33

Reaction of Human Endothelial Cells to Bovine Hemoglobin Solutions and Tumor Necrosis Factor

Simoni, J. M., Simoni, G., Lox, C. D., & Feola, M. (1994) · Artificial Cells Blood Substitutes and Biotechnology · doi:10.3109/10731199409117911 · Cited by 33

Effect of Oncotic Pressure of Diaspirin Cross-Linked Hemoglobin (DCLHb Trademark) on Brain Injury After Temporary Focal Cerebral Ischemia in Rats

Cole, D. J., Drummond, J. C., Patel, P. M., Nary, J. C., & Applegate, R. L. (1996) · Anesthesia & Analgesia · doi:10.1097/00000539-199608000-00024 · Cited by 33

Mechanisms of the adjuvant effect of hemoglobin in experimental peritonitis. VI. Effects of stroma-free hemoglobin and red blood cell stroma on mortality and neutrophil function.

Dl, D., Rd, N., Condie, R. M., & Simmons, R. L. (1983) · PubMed · Cited by 33

Oxygenation of tumors by a hemoglobin solution

Teicher, B. A., Schwartz, G. N., Sotomayor, E. A., Robinson, M. F., Dupuis, N. P., & Menon, K. (1993) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01200729 · Cited by 32

Reduction of extracellular methemoglobin by erythrocytes

McGown, E. L., Lyons, M. F., Marini, M., & Zegna, A. I. (1990) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(90)90035-u · Cited by 32

Oxygen delivery and autoxidation of hemoglobin

Marden, M. C., Griffon, N., & Poyart, C. (1995) · Transfusion Clinique et Biologique · doi:10.1016/s1246-7820(05)80074-6 · Cited by 32

Effect of saturated/unsaturated phosphatidylcholine ratio on the stability of liposome-encapsulated hemoglobin

Huang, Y., Chung, T., & Wu, C.-I. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(98)00204-x · Cited by 32

Fate of perfluorochemicals in animals after intravenous injection or hemodilution with their emulsions.

Yokoyama, K., Yamanouchi, K., Ohyanagi, H., & MITSUNO, T. (1978) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.26.956 · Cited by 32

Total and Partial Blood Exchange in the Rat with Hemoglobin Prepared by Crystallization

Venuto, F. D., Moores, W. Y., Zegna, A. I., & Zuck, T. F. (1977) · Transfusion · doi:10.1046/j.1537-2995.1977.17678075650.x · Cited by 31

Resuscitation and the limited utility of the present generation of blood substitutes

Hess, J. R., & Reiss, R. F. (1996) · Transfusion Medicine Reviews · doi:10.1016/s0887-7963(96)80003-4 · Cited by 31

Effect of hemoglobin solution on the response of intracranial and subcutaneous 9L tumors to antitumor alkylating agents

Teicher, B. A., Holden, S. A., Menon, K., Hopkins, R. E., & Gawryl, M. S. (1993) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00686024 · Cited by 31

Fluosol® and oxygen breathing as an adjuvant to radiation therapy in the treatment of locally advanced non-small cell carcinoma of the lung: Results of a phase I/II study

Lustig, R. A., Lowe, N., Prosnitz, L. R., Spaulding, M. B., Cohen, M. H., Stitt, J. A., & Brannon, R. B. (1990) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(90)90140-f · Cited by 31

Seventy-two-hour preservation of porcine liver by continuous hypothermic perfusion with UW solution in comparison with simple cold storage

Yamamoto, N., Konishi, Y., Wakashiro, S., Takayasu, T., Tatsumi, Y., Shimahara, Y., Tanaka, K., Yamaoka, Y., & Ozawa, K. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90109-y · Cited by 31

Actions of diaspirin cross-linked hemoglobin on isolated rat and dog vessels

Hart, J. L., Ledvina, M. A., & Muldoon, S. M. (1997) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(97)90184-0 · Cited by 31

Aldimine to ketoamine isomerization (Amadori rearrangement) potential at the individual nonenzymic glycation sites of hemoglobin a: Preferential inhibition of glycation by nucleophiles at sites of low isomerization potential

Acharya, A. S., Roy, R. P., & Dorai, B. (1991) · Journal of Protein Chemistry · doi:10.1007/bf01025633 · Cited by 31

Physiological Effect of Polyethylene Glycol Conjugation on Stroma‐Free Bovine Hemoglobin in the Conscious Dog After Partial Exchange Transfusion

Conover, C. D., Lejeune, L., Shum, K. L., Gilbert, C. W., & Shorr, R. (1997) · Artificial Organs · doi:10.1111/j.1525-1594.1997.tb00733.x · Cited by 31

Clinical Development of Perfluorocarbon-based Emulsions as Red Cell Substitutes

Kaufman, R. J. (1995) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-2576-8_5 · Cited by 30

Comparison of the haemodynamic effects of nitric oxide synthase inhibition and nitric oxide scavenging in endotoxaemic sheep

Bone, H. G., Waurick, R., Aken, H. V., Booke, M., PRIEN, T., & Meyer, J. (1998) · Intensive Care Medicine · doi:10.1007/s001340050514 · Cited by 30

Improved Blood Substitute

Simoni, J., Simoni, G., Martı́nez–Zaguilán, R., Wesson, D. E., Lox, C. D., Prien, S. D., & Kumar, R. V. (1998) · ASAIO Journal · doi:10.1097/00002480-199809000-00007 · Cited by 30

Lipid Peroxidation and Modification of Lipid Composition in an Endothelial Cell Model of Ischemia and Reperfusion

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Comparison of the efficacy of blood and polyethylene glycol‐hemoglobin in recovery of newborn piglets from hemorrhagic hypotension: effect on blood pressure, cortical oxygen, and extracellular dopamine in the brain

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