Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft

Hematocrit value on intensive care unit entry influences the frequency of Q-wave myocardial infarction after coronary artery bypass grafting

Spiess, B. D., Ley, C., Body, S. C., Siegel, L. C., Stover, E. P., Maddi, R., D'Ambra, M., Jain, U., Liu, F., Herskowitz, A., et al. (1998) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(98)70012-1 · Cited by 196

Immunomodulation by blood transfusion: an evolving scientific and clinical challenge

Blumberg, N., & Heal, J. M. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00124-6 · Cited by 192

Practice parameter for the use of red blood cell transfusions: developed by the Red Blood Cell Administration Practice Guideline Development Task Force of the College of American Pathologists.

Simon, T. L., Alverson, D. C., AuBuchon, J. P., Cooper, E. S., DeChristopher, P. J., Glenn, G. C., Gould, S. A., Harrison, C. R., Milam, J. D., Moise, K. J., et al. (1998) · PubMed · Cited by 191

Perioperative myocardial ischemic episodes are related to hematocrit level in patients undergoing radical prostatectomy

Hogue, C. W., Goodnough, L. T., & Monk, T. G. (1998) · Transfusion · doi:10.1046/j.1537-2995.1998.381098440856.x · Cited by 191

Blood Substitutes: Principles, Methods, Products and Clinical Trials: Vol. 1: Tissue Engineering

Chang, T. M. S. (1997) · KARGER eBooks · doi:10.1159/isbn.978-3-8055-6584-4 · Cited by 189

THE RENAL HANDLING OF HEMOGLOBIN

Bunn, H. F., Esham, W. T., & Bull, R. W. (1969) · The Journal of Experimental Medicine · doi:10.1084/jem.129.5.909 · Cited by 189

Characteristics of C-F Systems

Smart, B. E. (1994) · Organofluorine Chemistry · doi:10.1007/978-1-4899-1202-2_3 · Cited by 187

Stability of lipid emulsions for drug delivery

Washington, C. (1996) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00116-o · Cited by 186

HbXL99 alpha: a hemoglobin derivative that is cross-linked between the alpha subunits is useful as a blood substitute.

Snyder, S. R., Welty, E. V., Walder, R. Y., Williams, L. A., & Walder, J. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7280 · Cited by 185

The function of phospholipids of soybean lecithin in emulsions

Rydhag, L., & Wilton, I. (1981) · Journal of the American Oil Chemists Society · doi:10.1007/bf02665591 · Cited by 181

Surfactant association structure and emulsion stability

Friberg, S., Jansson, P. O., & Cederberg, E. (1976) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(76)90072-2 · Cited by 181

Safety of the Blood Supply in the United States: Opportunities and Controversies

AuBuchon, J. P., Birkmeyer, J. D., & Busch, M. P. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-10-199711150-00009 · Cited by 174

Pharmacokinetics and Side Effects of Perfluorocarbon-Based Blood Substitutes

Flaim, S. F. (1994) · Artificial Cells, Blood Substitutes, and Biotechnology · doi:10.3109/10731199409138801 · Cited by 174

Ueber Agglutiunationserscheinungen normalen menschlichen Bluters

Landsteiner, K. (1901) · Wiener klinische Wochenschrift · Cited by 174

The polyoxyethylene/polyoxypropylene block co‐polymer Poloxamer‐407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow

Porter, C. J. H., Moghimi, S. M., Illum, L., & Davis, S. S. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80655-z · Cited by 173

Stimulation by Nitroxides of Catalase-like Activity of Hemeproteins

Krishna, M. C., Samuni, A., Taira, J., Goldstein, S., Mitchell, J. B., & Russo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26018 · Cited by 173

Neurotoxicity of hemoglobin in cortical cell culture

Regan, R. F., & Panter, S. S. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90326-g · Cited by 172

The solubility of oxygen in highly fluorinated liquids

Wesseler, E. P., Iltis, R., & Clark, L. C. (1977) · Journal of Fluorine Chemistry · doi:10.1016/s0022-1139(00)82152-1 · Cited by 172

Polymerization of proteins with glutaraldehyde. Soluble molecular-weight markers

Payne, J. W. (1973) · Biochemical Journal · doi:10.1042/bj1350867 · Cited by 171

Allogeneic blood transfusions, immunomodulation, and postoperative bacterial infection: Do we have the answers yet?

Blajchman, M. A. (1997) · Transfusion · doi:10.1046/j.1537-2995.1997.37297203512.x · Cited by 168

Ostwald ripening in two-component disperse phase systems: Application to emulsion stability

Kabal'nov, A. S., Pertzov, A. V., & Shchukin, E. D. (1987) · Colloids and Surfaces · doi:10.1016/0166-6622(87)80258-5 · Cited by 168

Polymer Conjugates: Pharmacokinetic Considerations for Design and Development

Duncan, R., & Spreafico, F. (1994) · Clinical Pharmacokinetics · doi:10.2165/00003088-199427040-00004 · Cited by 164

The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide, or bovine retractor penis inhibitory factor

Martin, W., Smith, J. A., & White, D. G. (1986) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1986.tb11157.x · Cited by 162

The role of free surfactant in destabilizing oil-in-water emulsions

Aronson, M. P. (1989) · Langmuir · doi:10.1021/la00086a036 · Cited by 162

Biomaterials used in the posterior segment of the eye

Colthurst, M. J., Williams, R. L., Hiscott, P. S., & Grierson, I. (2000) · Biomaterials · doi:10.1016/s0142-9612(99)00220-3 · Cited by 162

Control of endothelial cell gene expression by flow

Malek, A. M., & Izumo, S. (1995) · Journal of Biomechanics · doi:10.1016/0021-9290(95)00099-2 · Cited by 162

Saturated and polymerizable amphiphiles with fluorocarbon chains. Investigation in monolayers and liposomes

Elbert, R., Folda, T., & Ringsdorf, H. (1984) · Journal of the American Chemical Society · doi:10.1021/ja00337a005 · Cited by 161

The binding of carbon dioxide by horse haemoglobin

Kilmartin, J. V., & Rossi-Bernardi, L. (1971) · Biochemical Journal · doi:10.1042/bj1240031 · Cited by 160

Metabolism of protein-free lipid emulsion models of chylomicrons in rats

Redgrave, T. G., & Maranhao, R. C. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90036-0 · Cited by 160

A randomized trial of perioperative hemodilution versus transfusion of preoperatively deposited autologous blood in elective surgery

Ness, P. M., Bourke, D. L., & Walsh, P. C. (1992) · Transfusion · doi:10.1046/j.1537-2995.1992.32392213805.x · Cited by 158

Depletion and Regeneration of 2,3‐diphosphoglyceric Acid in Stored Red Blood Cells

Beutler, E., Meul, A., & Wood, L. A. (1969) · Transfusion · doi:10.1111/j.1537-2995.1969.tb05527.x · Cited by 157

THE SEPSIS SYNDROME

Bone, R. C. (1996) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70307-5 · Cited by 156

Public perception of the risk ofblood transfusion

Finucane, M. L., Slovic, P., & Mertz, C. K. (2000) · Transfusion · doi:10.1046/j.1537-2995.2000.40081017.x · Cited by 154

Thrombolytic enhancement with perfluorocarbon-exposed sonicated dextrose albumin microbubbles

Porter, T. R., LeVeen, R. F., Fox, R., Kricsfeld, A., & Xie, F. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90006-x · Cited by 153

Epidemiology of blood transfusion

Vamvakas, E. C., & Taswell, H. F. (1994) · Transfusion · doi:10.1046/j.1537-2995.1994.34694295059.x · Cited by 153

Hemodilution Tolerance in Patients with Coronary Artery Disease Who Are Receiving Chronic beta-Adrenergic Blocker Therapy

Spahn, D. R., Schmid, E. R., Seifert, B., & Pasch, T. (1996) · Anesthesia & Analgesia · doi:10.1097/00000539-199604000-00003 · Cited by 152

Polyethylene Glycol-Modified Liposome-Encapsulated Hemoglobin: A Long Circulating Red Cell Substitute

Phillips, W. T., Klipper, R. W., Awasthi, V., Rudolph, A. S., Cliff, R. O., Kwasiborski, V., & Goins, B. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38004-8 · Cited by 149

Cellular antioxidant and pro-oxidant actions of nitric oxide

Joshi, M. S., Ponthier, J. L., & Lancaster, J. R. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00179-3 · Cited by 148

Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions

Lee, R. L., Neya, K., Svizzero, T., & Vlahakes, G. J. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.1.236 · Cited by 147

[51] Bifunctional reagents

Ji, T. H. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(83)91053-4 · Cited by 146

Diaspirins that crosslink .beta. chains of hemoglobin: bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate

Walder, J. A., Zaugg, R. H., Walder, R. Y., Steele, J. M., & Klotz, I. M. (1979) · Biochemistry · doi:10.1021/bi00587a001 · Cited by 144

Perfluorocarbon liquids in ophthalmology

Kramer, S. G., Hwang, D. G., Peyman, G. A., Schulman, J. A., & Sullivan, B. T. (1995) · Survey of Ophthalmology · doi:10.1016/s0039-6257(05)80093-1 · Cited by 143

Second harmonic imaging of an intravenously administered echocardiographic contrast agent

Mulvagh, S. L., Foley, D. A., Aeschbacher, B. C., Klarich, K. K., & Seward, J. B. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00619-2 · Cited by 141

Poly(ethylene glycol)-Modification of the Phospholipid Vesicles by Using the Spontaneous Incorporation of Poly(ethylene glycol)-Lipid into the Vesicles

Sou, K., Endo, T., Takeoka, S., & Tsuchida, E. (2000) · Bioconjugate Chemistry · doi:10.1021/bc990135y · Cited by 140

Human haemoglobin from transgenic tobacco

Dieryck, W., Pagnier, J., Poyart, C., Marden, M. C., Gruber, V., Bournat, P., Baudino, S., & Mérot, B. (1997) · Nature · doi:10.1038/386029b0 · Cited by 140

Red cell deformability and haematological disorders

Stuart, J., & Nash, G. B. (1990) · Blood Reviews · doi:10.1016/0268-960x(90)90041-p · Cited by 140

Fluorocarbon-Based in vivo Oxygen Transport and Delivery Systems

Riess, J. G. (1991) · Vox Sanguinis · doi:10.1159/000461363 · Cited by 139

Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution

Przybelski, R. J., Daily, E. K., Kisicki, J. C., Mattia‐Goldberg, C., Bounds, M. J., & Colburn, W. A. (1996) · Critical Care Medicine · doi:10.1097/00003246-199612000-00011 · Cited by 138

Hemoglobin, a newly recognized lipopolysaccharide (LPS)-binding protein that enhances LPS biological activity.

Kaca, W., Roth, R. I., & Levin, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31501-6 · Cited by 137

Reassessment of Criteria for the Selection of Perfluorochemicals for Second‐Generation Blood Substitutes: Analysis of Structure/Property Relationships

Riess, J. G. (1984) · Artificial Organs · doi:10.1111/j.1525-1594.1984.tb04243.x · Cited by 137

γδ T cell-induced nitric oxide production enhances resistance to mucosal candidiasis

Jones‐Carson, J., Vázquez‐Torres, A., van der Heyde, H. C., WARNER, T. F. C. S., Wagner, R. D., & Balish, E. (1995) · Nature Medicine · doi:10.1038/nm0695-552 · Cited by 135

Oxygen Transport by Erythrocyte/Hemoglobin Solution Mixtures in anin VitroCapillary as a Model of Hemoglobin-Based Oxygen Carrier Performance

Page, T. C., Light, W. R., McKay, C. B., et al. (1998) · Microvascular Research · doi:10.1006/mvre.1997.2055 · Cited by 134

Effects of a Hemoglobin-Based Oxygen Carrier (HBOC-201) on Hemodynamics and Oxygen Transport in Patients Undergoing Preoperative Hemodilution for Elective Abdominal Aortic Surgery

Kasper, S., Walter, M., Grüne, F., Bischoff, A., Erasmi, H., & Buzello, W. (1996) · Anesthesia & Analgesia · doi:10.1097/00000539-199611000-00006 · Cited by 134

Formation of Free Radicals and Nitric Oxide Derivative of Hemoglobin in Rats During Shock Syndrome

Westenberger, U., Thanner, S., Ruf, H. H., GERSONDE, K., Sutter, G., & Trentz, O. (1990) · Free Radical Research Communications · doi:10.3109/10715769009109680 · Cited by 133

The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution

LaMuraglia, G. M., O’Hara, P. J., Baker, W. H., Naslund, T. C., Norris, E. J., Li, J., & Vandermeersch, E. (2000) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(00)90161-7 · Cited by 132

X-ray diffraction and solution studies of specifically carbamylated human hemoglobin A. Evidence for the location of a proton- and oxygen-linked chloride binding site at valine 1 alpha.

O’Donnell, S. E., Mandaro, R., Schuster, T. M., & Arnone, A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86450-5 · Cited by 130

Poly(ethylene glycol)-Conjugation and Deoxygenation Enable Long-Term Preservation of Hemoglobin-Vesicles as Oxygen Carriers in a Liquid State

Sakai, H., Tomiyama, K.-I., Sou, K., Takeoka, S., & Tsuchida, E. (2000) · Bioconjugate Chemistry · doi:10.1021/bc990173h · Cited by 129

Transfusion Errors: Causes and Effects

Linden, J. V., & Kaplan, H. S. (1994) · Transfusion Medicine Reviews · doi:10.1016/s0887-7963(94)70109-7 · Cited by 126

Characterization of sonochemically prepared proteinaceous microspheres

Suslick, K. S., Grinstaff, M. W., Kolbeck, K. J., & Wong, M. (1994) · Ultrasonics Sonochemistry · doi:10.1016/1350-4177(94)90030-2 · Cited by 125

Highly fluorinated systems for oxygen transport, diagnosis and drug delivery

Riess, J. G. (1994) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/0927-7757(93)02696-c · Cited by 125

Hemoglobin-mediated oxidant damage to the central nervous system requires endogenous ascorbate.

Sadrzadeh, S. M. H., & Eaton, J. W. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113759 · Cited by 124

[36] Peroxidative activities of hemoglobin and hemoglobin derivatives

Everse, J., Johnson, M. C., & Marini, M. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)31038-6 · Cited by 122

Substituted benzaldehydes designed to increase the oxygen affinity of human haemoglobin and inhibit the sickling of sickle erythrocytes

Beddell, C. R., Goodford, P. J., Kneen, G., White, R. D., Wilkinson, S., & Wootton, R. (1984) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1984.tb10775.x · Cited by 121

Soluble dextran-hemoglobin complex as a potential blood substitute.

Tam, S., Blumenstein, J., & Wong, J. T.-F. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.6.2128 · Cited by 119

Synthesis of Functional Human Hemoglobin in Transgenic Mice

Behringer, R. R., Ryan, T. M., Reilly, M. P., Asakura, T., Palmiter, R. D., Brinster, R. L., & Townes, T. M. (1989) · Science · doi:10.1126/science.2772649 · Cited by 119

Ostwald ripening and the stability of emulsion systems: an explanation for the effect of an added third component

Davis, S. S., Round, H. P., & Purewal, T. S. (1981) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(81)90210-1 · Cited by 118

The Globin-based Free Radical of Ferryl Hemoglobin Is Detected in Normal Human Blood

Svistunenko, D. A., Patel, R. P., Voloshchenko, S. V., & Wilson, M. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.7114 · Cited by 117

Polymerized pyridoxylated hemoglobin: a red cell substitute with normal oxygen capacity.

Sehgal, L. R., Gould, S. A., Rosen, A. L., Hl, S., & Gs, M. (1984) · PubMed · Cited by 115

The protective effect of combined administration of anti-oxidants and perfluorochemicals on cerebral ischemia.

Suzuki, J., Fujimoto, S., Mizoi, K., & Oba, M. (1984) · Stroke · doi:10.1161/01.str.15.4.672 · Cited by 114

Protective effect of Fluosol-DA in acute cerebral ischemia.

Peerless, S. J., Ishikawa, R., Hunter, I. G., & Peerless, M. J. (1981) · Stroke · doi:10.1161/01.str.12.5.558 · Cited by 113

Perfluoro Compounds as Blood Substitutes

Riess, J. G., & Blanc, M. L. (1978) · Angewandte Chemie International Edition in English · doi:10.1002/anie.197806213 · Cited by 113

Increases in Oxygen Tension Evoke Arteriolar Constriction by Inhibiting Endothelial Prostaglandin Synthesis

Messina, E. J., Sun, D., Koller, Á., Wolin, M. S., & Kaley, G. (1994) · Microvascular Research · doi:10.1006/mvre.1994.1046 · Cited by 110

Reaction of acetaldehyde with hemoglobin.

George, R. C. S., & Hoberman, H. D. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62688-8 · Cited by 109

Blood substitutes : physiological basis of efficacy

Winslow, R. M., Vandegriff, K. D., & Intaglietta, M. (1995) · Medical Entomology and Zoology · Cited by 109

Development of antisickling compounds that chemically modify hemoglobin S specifically within the 2,3-diphosphoglycerate binding site

Walder, J. A., Walder, R. Y., & Arnone, A. (1980) · Journal of Molecular Biology · doi:10.1016/0022-2836(80)90385-x · Cited by 109

Solvent regulation of oxygen affinity in hemoglobin. Sensitivity of bovine hemoglobin to chloride ions.

Fronticelli, C., Bucci, E. M., & Orth, C. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90589-2 · Cited by 107

Allosteric modifiers of hemoglobin: 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, in whole blood, and in vivo in rats

Abraham, D. J., Wireko, F. C., Randad, R. S., Poyart, C., KISTER, J., Brohard-Bohn, B., Liard, J. F., & Kunert, M. P. (1992) · Biochemistry · doi:10.1021/bi00153a005 · Cited by 105

Partial Liquid Ventilation Decreases the Inflammatory Response in the Alveolar Environment of Trauma Patients

Croce, M. A., Fabian, T. C., Patton, J. H., Melton, S. M., Moore, M., & Trenthem, L. L. (1998) · doi:10.1097/00005373-199808000-00012 · Cited by 105

Fluorocarbon-Polyol Artificial Blood Substitutes

Steinmetz, P. R., Balko, C., & Geyer, R. P. (1973) · New England Journal of Medicine · doi:10.1056/nejm197311152892008 · Cited by 105

Cell-Free and Erythrocytic S -Nitrosohemoglobin Inhibits Human Platelet Aggregation

Pawloski, J. R., Swaminathan, R. V., & Stamler, J. S. (1998) · Circulation · doi:10.1161/01.cir.97.3.263 · Cited by 105

Glycosylation of hemoglobin in vitro: affinity labeling of hemoglobin by glucose-6-phosphate.

Haney, D. N., & Bunn, H. F. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3534 · Cited by 104

Nitrosyl-Hemoglobin Formation in the Blood of Animals Exposed to Nitric Oxide

Oda, H., Kusumoto, S., & Nakajima, T. (1975) · Archives of Environmental Health An International Journal · doi:10.1080/00039896.1975.10666749 · Cited by 104

Oxygen Transport in the Critically Ill

Bryan-Brown, C. W. (1987) · Critical Care Medicine · doi:10.1097/00003246-198712000-00030 · Cited by 104

Failure of Red Blood Cell Transfusion to Increase Oxygen Transport or Mixed Venous PO2 in Injured Patients

Shah, D. M., Gottlieb, M. E., Rahm, R. L., et al. (1982) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198209000-00004 · Cited by 103

Hemodilution in Clinical Surgery: State of the Art 1996

Kreimeier, U., & Meßmer, K. (1996) · World Journal of Surgery · doi:10.1007/s002689900184 · Cited by 103

alphaalpha-Crosslinked Hemoglobin: Was Failure Predicted by Preclinical Testing?

Winslow, R. M. (2000) · Vox Sanguinis · doi:10.1046/j.1423-0410.2000.7910001.x · Cited by 102

Solute-solvent interactions in perfluorocarbon solutions of oxygen. An NMR study

Hamza, M. A., Serratrice, G., Stébé, M. J., et al. (1981) · Journal of the American Chemical Society · doi:10.1021/ja00403a020 · Cited by 102

Effect of surface charge on the stability of oil/water emulsions during steam sterilization

Chansiri, G., Lyons, R. T., Patel, M. V., & Hem, S. L. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js980293i · Cited by 100

Fluorocarbons Reduce Myocardial Ischemic Damage After Coronary Occlusion

Glogar, D. H., Kloner, R. A., Muller, J. E., DeBoer, L. W. V., Braunwald, E., & Clark, L. C. (1981) · Science · doi:10.1126/science.7466402 · Cited by 100

Hemoglobin Autooxidation/Oxidation Mechanisms and Methemoglobin Prevention or Reduction Processes in the Bloodstream Literature review and outline of autooxidation reaction

Faivre, B., Menu, P., Labrude, P., & Vigneron, C. (1998) · Artificial Cells Blood Substitutes and Biotechnology · doi:10.3109/10731199809118943 · Cited by 100

Safety of the Blood Supply

Sloand, E. M. (1995) · JAMA · doi:10.1001/jama.1995.03530170048031 · Cited by 99

Detection of H2O2 release from vascular endothelial cells

Panus, P. C., Radí, R., Chumley, P. H., Lillard, R. H., & Freeman, B. A. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90013-k · Cited by 98

Randomized Safety Studies of Intravenous Perflubron Emulsion. II. Effects on Immune Function in Healthy Volunteers

Noveck, R. J., Shannon, E., Leese, P. T., Shorr, J. S., Flaim, K. E., Keipert, P. E., & Woods, C. M. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200010000-00009 · Cited by 98

Surface modification of haemoglobin-containing liposomes with polyethylene glycol prevents liposome aggregation in blood plasma

Yoshioka, H. (1991) · Biomaterials · doi:10.1016/0142-9612(91)90075-l · Cited by 97

Novel Lipid-Based Hollow-Porous Microparticles as a Platform for Immunoglobulin Delivery to the Respiratory Tract

Bot, A. I., Tarara, T. E., Smith, D. J., Bot, S., Woods, C. M., & Weers, J. G. (2000) · Pharmaceutical Research · doi:10.1023/a:1007544804864 · Cited by 95

Elevation of plasma viscosity induces sustained NO-mediated dilation in the hamster cremaster microcirculation in vivo

de Wit, C., von Bismarck, P., Bolz, S., Pohl, U., & Sch�fer, C. (1997) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050408 · Cited by 95

Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake

Carrstensen, H., Müller, R. H., & Müller, B. W. (1992) · Clinical Nutrition · doi:10.1016/0261-5614(92)90006-c · Cited by 95

Colloid osmotic properties of modified hemoglobins: chemically cross-linked versus polyethylene glycol surface-conjugated

Vandegriff, K. D., McCarthy, M. R., Rohlfs, R. J., & Winslow, R. M. (1997) · Biophysical Chemistry · doi:10.1016/s0301-4622(97)00079-3 · Cited by 94

Shear stress induces iNOS expression in cultured smooth muscle cells: role of oxidative stress

Gosgnach, W., Messika–Zeitoun, D., Gonzalez, W., Philipe, M., & Michel, J. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.6.c1880 · Cited by 94

Autoxidation of hemoglobin enhanced by dissociation into dimers.

Zhang, L., Levy, A., & Rifkind, J. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54286-1 · Cited by 93

Perfluorocarbon imaging in vivo: A 19F MRI study in tumor-bearing mice

Mason, R. P., Antich, P. P., Babcock, E. E., Gerberich, J. L., & Nunnally, R. L. (1989) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(89)90402-5 · Cited by 93

Hemoglobin Based Oxygen Carriers: How Much Methemoglobin is too Much?

Linberg, R., Conover, C. D., & Shum, K. L. (1998) · Artificial Cells Blood Substitutes and Biotechnology · doi:10.3109/10731199809119772 · Cited by 93

Reactive metabolites of oxygen and nitrogen in biology and medicine

Grisham, M. B. (1992) · Medical Entomology and Zoology · Cited by 92

Blood substitutes: evolution and future applications

Scott, M. G., Kucik, D. F., Goodnough, L. T., & Monk, T. G. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.9.1724 · Cited by 92

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