Comparative QSAR Analysis of Estrogen Receptor Ligands

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

Kuiper, G. G. J. M., Carlsson, B., Grandien, K., Enmark, E., Häggblad, J., Nilsson, S., & Gustafsson, J.-A. (1997) · Endocrinology · doi:10.1210/endo.138.3.4979 · Cited by 4,442

Molecular basis of agonism and antagonism in the oestrogen receptor

Brzozowski, A. M., Pike, A. C. W., Dauter, Z., Hubbard, R. E., Bonn, T., Engström, O., Öhman, L., Greene, G. L., Gustafsson, J.-Å., & Carlquist, M. (1997) · Nature · doi:10.1038/39645 · Cited by 3,355

ERβ: Identification and characterization of a novel human estrogen receptor

Mosselman, S., Polman, J., & Dijkema, R. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00782-x · Cited by 2,269

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

Paech, K., Webb, P., Kuiper, G. G. J. M., Nilsson, S., Gustafsson, J.-Å., Kushner, P. J., & Scanlan, T. S. (1997) · Science · doi:10.1126/science.277.5331.1508 · Cited by 1,861

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

Bourguet, W., Ruff, M., Chambon, P., Gronemeyer, H., & Moras, D. (1995) · Nature · doi:10.1038/375377a0 · Cited by 1,177

Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

Renaud, J.-P., Rochel, N., Ruff, M., Vivat, V., Chambon, P., Gronemeyer, H., & Moras, D. (1995) · Nature · doi:10.1038/378681a0 · Cited by 1,097

A canonical structure for the ligand-binding domain of nuclear receptors

Wurtz, J.-M., Bourguet, W., Renaud, J.-P., Vivat, V., Chambon, P., Moras, D., & Gronemeyer, H. (1996) · Nature Structural Biology · doi:10.1038/nsb0196-87 · Cited by 985

Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse

Couse, J. F., Lindzey, J., Grandien, K., Gustafsson, J.-A., & Korach, K. S. (1997) · Endocrinology · doi:10.1210/endo.138.11.5496 · Cited by 978

Nuclear receptor coactivators and corepressors

Horwitz, K. B. (1996) · Molecular Endocrinology · doi:10.1210/me.10.10.1167 · Cited by 942

A structural role for hormone in the thyroid hormone receptor

Wagner, R. L., Apriletti, J. W., McGrath, M. E., West, B. L., Baxter, J. D., & Fletterick, R. J. (1995) · Nature · doi:10.1038/378690a0 · Cited by 929

The use of characteristic volumes to measure cavity terms in reversed phase liquid chromatography

Abraham, M. H., & McGowan, J. C. (1987) · Chromatographia · doi:10.1007/bf02311772 · Cited by 858

The estrogenic activity of phthalate esters in vitro.

Harris, C. A., Henttu, P., Parker, M. G., & Sumpter, J. P. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105802 · Cited by 835

Calculating log Poct from structures

Leo, A. J. (1993) · Chemical Reviews · doi:10.1021/cr00020a001 · Cited by 695

The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site

Anstead, G. M., Carlson, K. E., & Katzenellenbogen, J. A. (1997) · Steroids · doi:10.1016/s0039-128x(96)00242-5 · Cited by 627

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones

Katzenellenbogen, J. A. (1996) · Molecular Endocrinology · doi:10.1210/me.10.2.119 · Cited by 535

Effects of tamoxifen on uterus and ovaries of postmenopausal women in a randomised breast cancer prevention trial

Kedar, R., Bourne, T. H., Collins, W. P., Campbell, S., Powles, T. J., Ashley, S., & Cosgrove, D. O. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92466-x · Cited by 531

Our stolen future: are we threatening our fertility, intelligence, and survival?--a scientific detective story

(1996) · Choice Reviews Online · doi:10.5860/choice.33-6336 · Cited by 464

The novel estrogen receptor‐β subtype: potential role in the cell‐ and promoter‐specific actions of estrogens and anti‐estrogens

Kuiper, G. G. J. M., & Gustafsson, J.-Å. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00413-4 · Cited by 400

Vinclozolin andp,p′-DDE Alter Androgen-Dependent Gene Expression:In VivoConfirmation of an Androgen Receptor-Mediated Mechanism

Kelce, W. R., Lambright, C. R., Gray, L. E., & Roberts, K. P. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.7966 · Cited by 353

A controlled trial of raloxifene (LY139481) HCl: Impact on bone turnover and serum lipid profile in healthy postmenopausal women

Draper, M. W., Flowers, D. E., Huster, W. J., Neild, J. A., Harper, K. D., & Arnaud, C. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110615 · Cited by 352

Environmental antiandrogens: developmental effects, molecular mechanisms, and clinical implications

Kelce, W. R., & Wilson, E. M. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050104 · Cited by 309

The estrogenicity of bisphenol A-related diphenylalkanes with various substituents at the central carbon and the hydroxy groups.

Perez, P., Pulgar, R., Olea-Serrano, F., Villalobos, M., Rivas, A., Metzler, M., Pedraza, V, & Olea, N. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106167 · Cited by 254

Ligand-Based Identification of Environmental Estrogens

Waller, C. L., Oprea, T. I., Chae, K., Park, H.-K., Korach, K. S., Laws, S. C., Wiese, T. E., Kelce, W. R., & Gray, L. E. (1996) · Chemical Research in Toxicology · doi:10.1021/tx960054f · Cited by 203

Evaluation of Quantitative Structure−Activity Relationship Methods for Large-Scale Prediction of Chemicals Binding to the Estrogen Receptor

Tong, W., Lowis, D. R., Perkins, R., Chen, Y., Welsh, W. J., Goddette, D. W., Heritage, T. W., & Sheehan, D. M. (1998) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci980008g · Cited by 202

Antiestrogens: Mechanisms of action and resistance in breast cancer

Katzenellenbogen, B. S., Montano, M. M., Ekena, K., Herman, M. E., & McInerney, E. M. (1997) · Breast Cancer Research and Treatment · doi:10.1023/a:1005835428423 · Cited by 179

Discovery and Synthesis of [6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]- 2-(4-hydroxyphenyl)]benzo[b]thiophene: A Novel, Highly Potent, Selective Estrogen Receptor Modulator

Palkowitz, A. D., Glasebrook, A. L., Thrasher, K. J., Hauser, K. L., Short, L. L., Phillips, D. L., Muehl, B. S., Sato, M., Shetler, P. K., Cullinan, G. J., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970167b · Cited by 177

Structure−Activity Relationships of Selective Estrogen Receptor Modulators: Modifications to the 2-Arylbenzothiophene Core of Raloxifene

Grese, T. A., Cho, S., Finley, D. R., Godfrey, A. G., Jones, C. D., Lugar, C. W., Martin, M. J., Matsumoto, K., Pennington, L. D., Winter, M. A., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm9606352 · Cited by 176

Quantitative structure-activity relationships and the unnamed science

Hansch, C. (1993) · Accounts of Chemical Research · doi:10.1021/ar00028a003 · Cited by 172

(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen

Gauthier, S., Caron, B., Cloutier, J., Dory, Y. L., Favre, A., Larouche, D., Mailhot, J., Ouellet, C., Schwerdtfeger, A., Leblanc, G., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970095o · Cited by 157

Editorial: A New Actor in the Estrogen Receptor Drama--Enter ER-

Katzenellenbogen, B. S., & Korach, K. S. (1997) · Endocrinology · doi:10.1210/endo.138.3.5080 · Cited by 150

Nuclear hormone receptors: ligand-activated regulators of transcription and diverse cell responses

Katzenelienbogen, J. A., & Katzenellenbogen, B. S. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90143-x · Cited by 147

Molecular graphics and QSAR in the study of enzyme-ligand interactions. On the definition of bioreceptors

Hansch, C. H., & Klein, T. E. (1986) · Accounts of Chemical Research · doi:10.1021/ar00132a003 · Cited by 141

Comparative QSAR: Radical Reactions of Benzene Derivatives in Chemistry and Biology

Hansch, C. H., & Gao, H. (1997) · Chemical Reviews · doi:10.1021/cr9601021 · Cited by 135

Regio and stereospecific synthesis of 11β-substituted 19-norsteroids

Bèlanger, A., Philibert, D., & Teutsch, G. (1981) · Steroids · doi:10.1016/0039-128x(81)90039-8 · Cited by 132

The future of new pure antiestrogens in clinical breast cancer

Wakeling, A. E. (1993) · Breast Cancer Research and Treatment · doi:10.1007/bf00662395 · Cited by 131

QSAR Models for Binding of Estrogenic Compounds to Estrogen Receptor α and β Subtypes

Tong, W., Perkins, R., Xing, L., Welsh, W. J., & Sheehan, D. M. (1997) · Endocrinology · doi:10.1210/endo.138.9.5487 · Cited by 127

2-Arylindenes and 2-arylindenones: molecular structures and considerations in the binding orientation of unsymmetrical nonsteroidal ligands to the estrogen receptor

Anstead, G. M., Wilson, S. R., & Katzenellenbogen, J. A. (1989) · Journal of Medicinal Chemistry · doi:10.1021/jm00129a024 · Cited by 123

Commentary: The Structural Pervasiveness of Estrogenic Activity

Katzenellenbogen, J. A. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103s799 · Cited by 90

Using Three-Dimensional Quantitative Structure-Activity Relationships to Examine Estrogen Receptor Binding Affinities of Polychlorinated Hydroxybiphenyls

Waller, C. L., Minor, D. L., & McKinney, J. D. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103702 · Cited by 89

Quantitative Structure-Activity Relationships/Comparative Molecular Field Analysis (QSAR/CoMFA) for Receptor-Binding Properties of Halogenated Estradiol Derivatives

Gantchev, T. G., Ali, H., & van Lier, J. E. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00050a013 · Cited by 78

Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia.

Evans, G. L., Bryant, H. U., Magee, D. E., et al. (1996) · Endocrinology · doi:10.1210/endo.137.10.8828469 · Cited by 75

Phenol toxicity in leukemia cells: a radical process?

Selassie, C. D., DeSoyza, T. V., del Rosario, M. C., Gao, H., & Hansch, C. H. (1998) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(98)00027-1 · Cited by 69

11β-Amidoalkoxyphenyl estradiols, a new series of pure antiestrogens

Nique, F., Velde, P. V. D., Brémaud, J., Hardy, M., Philibert, D., & Teutsch, G. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90168-6 · Cited by 69

Kinetics of the hormone-receptor interaction competition experiments with slowly equilibrating ligands

Arányi, P. (1980) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(80)90369-4 · Cited by 58

Three-Dimensional Quantitative Structure−Activity Relationship Study of Nonsteroidal Estrogen Receptor Ligands Using the Comparative Molecular Field Analysis/Cross-Validated r2-Guided Region Selection Approach

Sadler, B. R., Cho, S. J., Ishaq, K. S., Chae, K., & Korach, K. S. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm9705521 · Cited by 52

Optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase

Selassie, C. D., Li, R., Poe, M., et al. (1991) · Journal of Medicinal Chemistry · doi:10.1021/jm00105a008 · Cited by 51

QSAR treatment of multiple toxicities: the mutagenicity and cytotoxicity of quinolines

Smith, C. J., Hansch, C. H., & Morton, M. J. (1997) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00118-8 · Cited by 33

17α -Substituted analogs of estradiol for the development of fluorescent estrogen receptor ligands

Salman, M., Reddy, B. R., Delgado, P., Stotter, P. L., Fulcher, L. C., & Chamness, G. C. (1991) · Steroids · doi:10.1016/0039-128x(91)90070-c · Cited by 29

11.beta.-Substituted Estradiol Derivatives, Potential High-Affinity Carbon-11-Labeled Probes for the Estrogen Receptor: A Structure-Affinity Relationship Study

Napolitano, E., Fiaschi, R., Carlson, K. E., & Katzenellenbogen, J. A. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00003a005 · Cited by 26

Molecular modeling studies on 11β-aminoethoxyphenyl and 7α-aminoethoxyphenyl estradiols. evidence suggesting a common hydrophobic pocket in estrogen receptor

Poupaert, J. H., Lambert, D. M., Vamecq, J., & Abul‐Hajj, Y. J. (1995) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/0960-894x(95)00128-g · Cited by 20

Quantitative Structure-Activity Relationship of Various Endogenous Estrogen Metabolites for Human Estrogen Receptor α and β Subtypes: Insights into the Structural Determinants Favoring a Differential Subtype Binding

Zhu, B. T., Han, G.-Z., Shim, J.-Y., Wen, Y., & Jiang, X.-R. (2006) · Endocrinology · doi:10.1210/en.2006-0113 · Cited by 271