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Cited by 320

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Dispersion and Stability Optimization of TiO2 Nanoparticles in Cell Culture Media

Open access
Ji, Zhaoxia, Jin, Xue, George, Saji, Xia, Tian, Meng, Huan, Wang, Xiang, Suarez, Elizabeth, Zhang, Haiyuan, Hoek, Eric M.V., Godwin, Hilary, Nel, André E., Zink, Jeffrey I.·2010·Environmental Science & Technology

Abstract

Accurate evaluation of engineered nanomaterial toxicity requires not only comprehensive physical-chemical characterization of nanomaterials as produced, but also thorough understanding of nanomaterial properties and behavior under conditions similar to those used for in vitro and in vivo toxicity studies. In this investigation, TiO(2) nanoparticles were selected as a model nanoparticle and bovine serum albumin (BSA) was selected as a model protein for studying the effect of protein-nanoparticle interaction on TiO(2) nanoparticle dispersion in six different mammalian, bacteria, and yeast cell culture media. Great improvement in TiO(2) dispersion was observed upon the addition of BSA, even though the degree of dispersion varied from medium to medium and phosphate concentration in the cell culture media was one of the key factors governing nanoparticle dispersion. Fetal bovine serum (FBS) was an effective dispersing agent for TiO(2) nanoparticles in all six media due to synergistic effects of its multiple protein components, successfully reproduced using a simple "FBS mimic" protein cocktail containing similar concentrations of BSA, γ-globulin, and apo-transferrin.

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Crossref · 10.1021/es100417s

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Metadata

Authors
Ji, Z., Jin, X., George, S., Xia, T., Meng, H., Wang, X., Suarez, E., Zhang, H., Hoek, E. M. V., Godwin, H., Nel, A. E., & Zink, J. I.
Venue
Environmental Science & Technology
Published
2010-06-10
Volume
44
Issue
19
Pages
7309-7314
ISSN
  • 0013-936X (ISSN-L)
  • 1520-5851
OpenAlex
W1964353134
Cited by
320
References
1
FWCI
12.36
Type
journal article
Language
en
Open access
green

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