CoChat
Sign Up
Cited by 209Indoor Air Quality and Microbial ExposureToxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals

Dermal Uptake of Organic Vapors Commonly Found in Indoor Air

Open access
Weschler, Charles J., Nazaroff, William W·2014·Environmental Science & Technology
DOI 10.1021/es405490a
Open this paper in CoChat — free accountOpen PDF

Abstract

Transdermal uptake directly from air is a potentially important yet largely overlooked pathway for human exposure to organic vapors indoors. We recently reported (Indoor Air 2012, 22, 356) that transdermal uptake directly from air could be comparable to or larger than intake via inhalation for many semivolatile organic compounds (SVOCs). Here, we extend that analysis to approximately eighty organic compounds that (a) occur commonly indoors and (b) are primarily in the gas-phase rather than being associated with particles. For some compounds, the modeled ratio of dermal-to-inhalation uptake is large. In this group are common parabens, lower molecular weight phthalates, o-phenylphenol, Texanol, ethylene glycol, and α-terpineol. For other compounds, estimated dermal uptakes are small compared to inhalation. Examples include aliphatic hydrocarbons, single ring aromatics, terpenes, chlorinated solvents, formaldehyde, and acrolein. Analysis of published experimental data for human subjects for twenty different organic compounds substantiates these model predictions. However, transdermal uptake rates from air have not been measured for the indoor organics that have the largest modeled ratios of dermal-to-inhalation uptake; for such compounds, the estimates reported here require experimental verification. In accounting for total exposure to indoor organic pollutants and in assessing potential health consequences of such exposures, it is important to consider direct transdermal absorption from air.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1021/es405490a

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Levels of uptake of airborne pollutants by the transcutaneous route are similar to those measured after inhalation of some indoor pollutants such as SVOCs and other VOCs.

    “Levels of uptake of airborne pollutants by the transcutaneous route have been reported to be similar to those measured after the inhalation of some indoor pollutants such as SVOCs and other VOCs15, 16, 17 (Table 1).”

    From The impact of airborne pollution on skin (2019) · cites this paper as [16]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Weschler, C. J., & Nazaroff, W. W.
Affiliations
  • Rutgers, The State University of New Jersey (US)
  • University of California, Berkeley (US)
Corresponding author
Weschler, Charles J.
ORCID
Venue
Environmental Science & Technology
Publisher
American Chemical Society (ACS)
Published
2013-12-26
Volume
48
Issue
2
Pages
1230-1237
ISSN
  • 0013-936X (ISSN-L)
  • 1520-5851
DOI
10.1021/es405490a
OpenAlex
W2334055317
Cited by
209
References
52
Citations by year
2026: 15 · 2025: 16 · 2024: 18 · 2023: 22 · 2022: 19 · 2021: 14 · 2020: 15 · 2019: 16 · 2018: 19 · 2017: 14 · 2016: 15 · 2015: 18 · 2014: 8
FWCI
10.02
Type
journal article
Language
en
Open access
Locations
  • Environmental Science & Technology (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords
percutaneous absorption, indoor air, organic vapors, semi-volatile organic compounds, human exposure pathways, phthalates, parabens, o-phenylphenol, ethylene glycol, α-terpineol, aliphatic hydrocarbons, terpenes, chlorinated solvents, formaldehyde, acrolein, exposure modeling
MeSH terms
Air Pollutants, Humans, Organic Chemicals, Permeability, Volatilization, Air Pollution, Indoor, Inhalation Exposure, Dermis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review