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Bio-Barcodes Based on Oligonucleotide-Modified Nanoparticles
Abstract
By utilizing oligonucleotide-modified Au nanoparticles encoded with sequences that act as biobarcodes, one can screen for multiple target polyvalent proteins simultaneously in one solution. This novel concept was demonstrated with two types of detection formats, a homogeneous assay and one based on oligonucleotide microarrays. With such an approach, one can prepare an extraordinarily large number of barcodes from synthetically accessible oligonucleotides (e.g., a 12-mer sequence offers 4(12) possible barcodes).
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Citations
Cited by
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Self-citationGhosh, S. K., & Pal, T. (2007) · Chemical Reviews · doi:10.1021/cr0680282 · Cited by 2,782
Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins
Nam, J.-M., Thaxton, C. S., & Mirkin, C. A. (2003) · Science · doi:10.1126/science.1088755 · Cited by 2,390
Self-citationGupta, A. K., Naregalkar, R. R., Vaidya, V. D., & Gupta, M. (2007) · Nanomedicine · doi:10.2217/17435889.2.1.23 · Cited by 708
Immuno-PCR: high sensitivity detection of proteins by nucleic acid amplification
Niemeyer, C. M., Adler, M., & Wacker, R. (2005) · Trends in Biotechnology · doi:10.1016/j.tibtech.2005.02.006 · Cited by 320
Metadata
- Authors
- Nam, J.-M., Park, S.-J., & Mirkin, C. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-03-21
- Volume
- 124
- Issue
- 15
- Pages
- 3820-3821
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W4231457427
- Cited by
- 245
- References
- 0
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nam, J.-M., Park, S.-J., & Mirkin, C. A. (2002). Bio-Barcodes Based on Oligonucleotide-Modified Nanoparticles. Journal of the American Chemical Society. https://doi.org/10.1021/ja0178766
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