The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes
Abstract
The first enantioselective catalytic direct cross-aldol reaction that employs nonequivalent aldehydes has been accomplished using proline as the reaction catalyst. Structural variation in both the aldol donor (R1 = Me, n-Bu, Bn, 91 to >99%) and aldol acceptor (R2 = I-Pr, I-Bu, c-C6H11, Et, Ph, 97-99% ee) are possible while maintaining high reaction efficiency (75-88% yield). Significantly, this new aldol variant allows facile enantioselective access to a broad range of beta-hydroxy aldehydes which are valuable intermediates in polyketide syntheses.
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Citations
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Metadata
- Authors
- Northrup, A. B., & MacMillan, D. W. C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-05-08
- Volume
- 124
- Issue
- 24
- Pages
- 6798-6799
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2045154252
- Cited by
- 706
- References
- 12
- FWCI
- 38.38
- Type
- journal article
- Language
- en
- Open access
- closed
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