The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Screening of Protein Crystallization Conditions on a Microfluidic Chip Using Nanoliter-Size Droplets
Abstract
Protein crystallization is a major bottleneck in determining tertiary protein structures from genomic sequence data. This paper describes a microfluidic system for screening hundreds of protein crystallization conditions using less than 4 nL of protein solution for each crystallization droplet. The droplets are formed by mixing protein, precipitant, and additive stock solutions in variable ratios in a flow of water-immiscible fluids inside microchannels. Each droplet represents a discrete trial testing different conditions. The system has been validated by crystallization of several water-soluble proteins.
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Citations
Cites
Vesicles and Polymerized Vesicles from Thiophene‐Containing Rod–Coil Block Copolymers
Vriezema, D. M., Hoogboom, J., Velonia, K., Takazawa, K., Christianen, P. C. M., Maan, J. C., Rowan, A. E., & Nolte, R. J. M. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200390204 · Cited by 334
Cited by
Teh, S.-Y., Lin, R., Hung, L.-H., & Lee, A. P. (2008) · Lab on a Chip · doi:10.1039/b715524g · Cited by 2,690
Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications
Mark, D., Haeberle, S., Roth, G., von Stetten, F., & Zengerle, R. (2010) · Chemical Society Reviews · doi:10.1039/b820557b · Cited by 1,647
Whitesides, G. M. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201800907 · Cited by 850
Synthesis of micro and nanostructures in microfluidic systems
Marre, S., & Jensen, K. F. (2010) · Chemical Society Reviews · doi:10.1039/b821324k · Cited by 734
Microfluidic cell culture systems for drug research
Wu, M.-H., Huang, S.-B., & Lee, G.-B. (2010) · Lab on a Chip · doi:10.1039/b921695b · Cited by 432
Metadata
- Authors
- Zheng, B., Roach, L. S., & Ismagilov, R. F.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-08-23
- Volume
- 125
- Issue
- 37
- Pages
- 11170-11171
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2020068704
- Cited by
- 697
- References
- 1
- FWCI
- 22.29
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
