The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An Investigation of the Mechanisms of Electronic Sensing of Protein Adsorption on Carbon Nanotube Devices
Abstract
It has been reported that protein adsorption on single-walled carbon nanotube field effect transistors (FETs) leads to appreciable changes in the electrical conductance of the devices, a phenomenon that can be exploited for label-free detection of biomolecules with a high potential for miniaturization. This work presents an elucidation of the electronic biosensing mechanisms with a newly developed microarray of nanotube "micromat" sensors. Chemical functionalization schemes are devised to block selected components of the devices from protein adsorption, self-assembled monolayers (SAMs) of methoxy(poly(ethylene glycol))thiol (mPEG-SH) on the metal electrodes (Au, Pd) and PEG-containing surfactants on the nanotubes. Extensive characterization reveals that electronic effects occurring at the metal-nanotube contacts due to protein adsorption constitute a more significant contribution to the electronic biosensing signal than adsorption solely along the exposed lengths of the nanotubes.
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Citations
Cites
Enzyme-coated carbon nanotubes as single-molecule biosensors
Besteman, K., Lee, J.-O., Wiertz, F. G. M., Heering, H. A., & Dekker, C. (2003) · Nano Letters · doi:10.1021/nl034139u · Cited by 1,294
Cited by
Label-free immunodetection with CMOS-compatible semiconducting nanowires
Stern, E., Klemic, J. F., Routenberg, D. A., Wyrembak, P. N., Turner-Evans, D. B., Hamilton, A. D., LaVan, D. A., Fahmy, T. M., & Reed, M. A. (2007) · Nature · doi:10.1038/nature05498 · Cited by 1,352
Electrical detection of single viruses
Patolsky, F., Zheng, G., Hayden, O., Lakadamyali, M., Zhuang, X., & Lieber, C. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406159101 · Cited by 1,258
Supersensitive, Fast‐Response Nanowire Sensors by Using Schottky Contacts
Hu, Y., Zhou, J., Yeh, P., Li, Z., Wei, T., & Wang, Z. L. (2010) · Advanced Materials · doi:10.1002/adma.201000278 · Cited by 346
Kuang, Z., Kim, S. N., Crookes-Goodson, W. J., Farmer, B. L., & Naik, R. R. (2010) · ACS Nano · doi:10.1021/nn901365g · Cited by 184
Metadata
- Authors
- Chen, R. J., Choi, H. C., Bangsaruntip, S., Yenilmez, E., Tang, X., Wang, Q., Chang, Y.-L., & Dai, H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-01-15
- Volume
- 126
- Issue
- 5
- Pages
- 1563-1568
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2072492058
- Cited by
- 516
- References
- 1
- FWCI
- 40.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
