The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
An Investigation of the Mechanisms of Electronic Sensing of Protein Adsorption on Carbon Nanotube Devices
Abstract
It has been reported that protein adsorption on single-walled carbon nanotube field effect transistors (FETs) leads to appreciable changes in the electrical conductance of the devices, a phenomenon that can be exploited for label-free detection of biomolecules with a high potential for miniaturization. This work presents an elucidation of the electronic biosensing mechanisms with a newly developed microarray of nanotube "micromat" sensors. Chemical functionalization schemes are devised to block selected components of the devices from protein adsorption, self-assembled monolayers (SAMs) of methoxy(poly(ethylene glycol))thiol (mPEG-SH) on the metal electrodes (Au, Pd) and PEG-containing surfactants on the nanotubes. Extensive characterization reveals that electronic effects occurring at the metal-nanotube contacts due to protein adsorption constitute a more significant contribution to the electronic biosensing signal than adsorption solely along the exposed lengths of the nanotubes.
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Cites
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Metadata
- Authors
- Chen, R. J., Choi, H. C., Bangsaruntip, S., Yenilmez, E., Tang, X., Wang, Q., Chang, Y.-L., & Dai, H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-01-15
- Volume
- 126
- Issue
- 5
- Pages
- 1563-1568
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2072492058
- Cited by
- 516
- References
- 22
- FWCI
- 40.22
- Type
- journal article
- Language
- en
- Open access
- closed
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