The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Electrical detection of single viruses
Open accessAbstract
We report direct, real-time electrical detection of single virus particles with high selectivity by using nanowire field effect transistors. Measurements made with nanowire arrays modified with antibodies for influenza A showed discrete conductance changes characteristic of binding and unbinding in the presence of influenza A but not paramyxovirus or adenovirus. Simultaneous electrical and optical measurements using fluorescently labeled influenza A were used to demonstrate conclusively that the conductance changes correspond to binding/unbinding of single viruses at the surface of nanowire devices. pH-dependent studies further show that the detection mechanism is caused by a field effect, and that the nanowire devices can be used to determine rapidly isoelectric points and variations in receptor-virus binding kinetics for different conditions. Lastly, studies of nanowire devices modified with antibodies specific for either influenza or adenovirus show that multiple viruses can be selectively detected in parallel. The possibility of large-scale integration of these nanowire devices suggests potential for simultaneous detection of a large number of distinct viral threats at the single virus level.
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Cites
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Self-citationHigh Performance Silicon Nanowire Field Effect Transistors
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Self-citationNoncovalent functionalization of carbon nanotubes for highly specific electronic biosensors
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Cited by
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
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Electrochemical biosensors: Towards point-of-care cancer diagnostics
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Label-free immunodetection with CMOS-compatible semiconducting nanowires
Stern, E., Klemic, J. F., Routenberg, D. A., Wyrembak, P. N., Turner-Evans, D. B., Hamilton, A. D., LaVan, D. A., Fahmy, T. M., & Reed, M. A. (2007) · Nature · doi:10.1038/nature05498 · Cited by 1,352
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Metadata
- Authors
- Patolsky, F., Zheng, G., Hayden, O., Lakadamyali, M., Zhuang, X., & Lieber, C. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-09-13
- Volume
- 101
- Issue
- 39
- Pages
- 14017-14022
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053192345
- Cited by
- 1,258
- References
- 17
- FWCI
- 42.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Patolsky, F., Zheng, G., Hayden, O., Lakadamyali, M., Zhuang, X., & Lieber, C. M. (2004). Electrical detection of single viruses. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0406159101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
