The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Lactosylated Poly(ethylene glycol)-siRNA Conjugate through Acid-Labile β-Thiopropionate Linkage to Construct pH-Sensitive Polyion Complex Micelles Achieving Enhanced Gene Silencing in Hepatoma Cells
Abstract
The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling lactosylated-PEG-siRNA conjugates bearing acid-labile beta-thiopropionate linkages into polyion complex (PIC) micelles through the mixing with poly(l-lysine). The PIC micelles with clustered lactose moieties on the periphery were successfully transported into hepatoma cells in a receptor-mediated manner, releasing hundreds of active siRNA molecules into the cellular interior responding to the pH decrease in the endosomal compartment. Eventually, almost 100 times enhancement in gene silencing activity compared to that of the free conjugate was achieved for the micelle system, facilitating the practical utility of siRNA therapeutics.
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Cites
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The effect of the linker on the hydrolysis rate of drug-linked ester bonds
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Self-citationCross-Linked Microparticles as Carriers for the Delivery of Plasmid DNA for Vaccine Development
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Cited by
Knocking down barriers: advances in siRNA delivery
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Design of polymeric nanoparticles for biomedical delivery applications
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Block copolymer micelles: preparation, characterization and application in drug delivery
Gaucher, G., Dufresne, M.-H., Sant, V. P., Kang, N., Maysinger, D., & Leroux, J.-C. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.034 · Cited by 1,498
Block copolymer micelles in nanomedicine applications
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Self-citationBioapplications of RAFT Polymerization
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Metadata
- Authors
- Oishi, M., Nagasaki, Y., Itaka, K., Nishiyama, N., & Kataoka, K.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-01-22
- Volume
- 127
- Issue
- 6
- Pages
- 1624-1625
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2011569859
- Cited by
- 476
- References
- 12
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Lactosylated Poly(ethylene glycol)-siRNA Conjugate through Acid-Labile β-Thiopropionate Linkage to Construct pH-Sensitive Polyion Complex Micelles Achieving Enhanced Gene Silencing in Hepatoma Cells. https://app.cochat.ai/papers/10.1021/ja044941d
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- Oishi, M., Nagasaki, Y., Itaka, K., Nishiyama, N., & Kataoka, K. (2005). Lactosylated Poly(ethylene glycol)-siRNA Conjugate through Acid-Labile β-Thiopropionate Linkage to Construct pH-Sensitive Polyion Complex Micelles Achieving Enhanced Gene Silencing in Hepatoma Cells. Journal of the American Chemical Society. https://doi.org/10.1021/ja044941d
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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