The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Folate-Receptor-Mediated Delivery of InP Quantum Dots for Bioimaging Using Confocal and Two-Photon Microscopy
Abstract
A novel method for the synthesis of highly monodispersed hydrophillic InP-ZnS nanocrystals and their use as luminescence probes for live cell imaging is reported. Hydrophobic InP-ZnS nanocrystals are prepared by a new method that yields high-quality, luminescent core-shell nanocrystals within 6-8 h of total reaction time. Then by carefully manipulating the surface of these passivated nanocrystals, aqueous dispersions of folate-conjugated nanocrystals (folate-QDs) with high photostability are prepared. By use of confocal microscopy, we demonstrate the receptor-mediated delivery of folic acid conjugated quantum dots into folate-receptor-positive cell lines such as KB cells. These folate-QDs tend to accumulate in multi-vescicular bodies of KB cells after 6 h of incubation. Receptor-mediated delivery was confirmed by comparison with the uptake of these particles in folate-receptor-negative cell lines such as A549. Efficient two-photon excitation of these particles and two-photon imaging using these particles are also demonstrated. The use of these InP-ZnS nanoparticles and their efficient two-photon excitation can be potentially useful for deep tissue imaging for future in vivo studies.
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Cites
Dabbousi, B. O., Rodriguez-Viejo, J., Mikulec, F. V., Heine, J. R., Mattoussi, H., Ober, R., Jensen, K. F., & Bawendi, M. G. (1997) · The Journal of Physical Chemistry B · doi:10.1021/jp971091y · Cited by 4,229
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Senapati, S., Mahanta, A. K., Kumar, S., & Maiti, P. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-017-0004-3 · Cited by 2,167
An Aqueous Route to Multicolor Photoluminescent Carbon Dots Using Silica Spheres as Carriers
Liu, R., Wu, D., Liu, S., Koynov, K., Knoll, W., & Li, Q. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900652 · Cited by 965
Li, H., He, X., Liu, Y., Huang, H., Lian, S., Lee, S.-T., & Kang, Z. (2011) · Carbon · doi:10.1016/j.carbon.2010.10.004 · Cited by 913
New Generation Cadmium-Free Quantum Dots for Biophotonics and Nanomedicine
Xu, G., Zeng, S., Zhang, B., Swihart, M. T., Yong, K.-T., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00290 · Cited by 587
Self-citationBrunetti, V., Chibli, H., Fiammengo, R., Galeone, A., Malvindi, M. A., Vecchio, G., Cingolani, R., Nadeau, J. L., & Pompa, P. P. (2013) · Nanoscale · doi:10.1039/c2nr33024e · Cited by 346
Metadata
- Authors
- Bharali, D. J., Lucey, D. W., Jayakumar, H., Pudavar, H. E., & Prasad, P. N.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-07-26
- Volume
- 127
- Issue
- 32
- Pages
- 11364-11371
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2015182838
- Cited by
- 473
- References
- 1
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- closed
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