The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Using a Kinase/Phosphatase Switch to Regulate a Supramolecular Hydrogel and Forming the Supramolecular Hydrogel in Vivo
Abstract
We have designed and synthesized a new hydrogelator Nap-FFGEY (1), which forms a supramolecular hydrogel. A kinase/phosphatase switch is used to control the phosphorylation and dephosphorylation of the hydrogelator and to regulate the formation of supramolecular hydrogels. Adding a kinase to the hydrogel induces a gel-sol phase transition in the presence of adenosine triphosphates (ATP) because the tyrosine residue is converted into tyrosine phosphate by the kinase to give a more hydrophilic molecule of Nap-FFGEY-P(O)(OH)(2) (2); treating the resulting solution with a phosphatase transforms 2 back to 1 and restores the hydrogel. Electron micrographs of the hydrogels indicate that 1 self-assembles into nanofibers. Subcutaneous injection of 2 in mice shows that 80.5 +/- 1.2% of 2 turns into 1 and results in the formation of the supramolecular hydrogel of 1 in vivo. This simple biomimetic approach for regulating the states of supramolecular hydrogels promises a new way to design and construct biomaterials.
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Cites
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
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Self-citationSupramolecular Hydrogel Exhibiting Four Basic Logic Gate Functions To Fine-Tune Substance Release
Komatsu, H., Matsumoto, S., Tamaru, S.-I., Kaneko, K., Ikeda, M., & Hamachi, I. (2009) · Journal of the American Chemical Society · doi:10.1021/ja8098239 · Cited by 305
Reaction–diffusion processes at the nano- and microscales
Epstein, I. R., & Xu, B. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.41 · Cited by 284
Self-citationSwitching the adhesive state of catecholic hydrogels using phototitration
White, E. M., Seppala, J. E., Rushworth, P. M., Ritchie, B. W., Sharma, S., & Locklin, J. (2013) · Macromolecules · doi:10.1021/ma401594z · Cited by 58
Metadata
- Authors
- Yang, Z., Liang, G., Wang, L., & Xu, B.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-02-10
- Volume
- 128
- Issue
- 9
- Pages
- 3038-3043
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1989873976
- Cited by
- 485
- References
- 12
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, Z., Liang, G., Wang, L., & Xu, B. (2006). Using a Kinase/Phosphatase Switch to Regulate a Supramolecular Hydrogel and Forming the Supramolecular Hydrogel in Vivo. Journal of the American Chemical Society. https://doi.org/10.1021/ja057412y
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