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A Lead(II)-Driven DNA Molecular Device for Turn-On Fluorescence Detection of Lead(II) Ion with High Selectivity and Sensitivity

Li, Tao, Dong, Shaojun, Wang, Erkang·2010·Journal of the American Chemical Society

Abstract

A Pb(2+)-driven DNA molecular device which is constructed based on a DNA duplex-quadruplex exchange is utilized for the highly selective and sensitive detection of Pb(2+). The power of this DNA device originates from the excellent efficiency of Pb(2+) for stabilizing G-quadruplexes, which makes the DNA duplex unwind thereby driving the device. This device can be reset to the original state by addition of a strong Pb(2+) chelator DOTA, endowing the device with good reusability. In the whole process, the signal readout is modulated via a fluorescent probe binding to and being released from the G-quadruplex. Such a DNA device can serve as a novel turn-on fluorescent sensor for Pb(2+) detection with high selectivity and sensitivity.

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Metadata

Authors
Li, T., Dong, S., & Wang, E.
Venue
Journal of the American Chemical Society
Published
2010-09-07
Volume
132
Issue
38
Pages
13156-13157
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2326374014
Cited by
374
References
0
FWCI
9.57
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A Lead(II)-Driven DNA Molecular Device for Turn-On Fluorescence Detection of Lead(II) Ion with High Selectivity and Sensitivity. https://app.cochat.ai/papers/10.1021/ja105849m
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Li, T., Dong, S., & Wang, E. (2010). A Lead(II)-Driven DNA Molecular Device for Turn-On Fluorescence Detection of Lead(II) Ion with High Selectivity and Sensitivity. Journal of the American Chemical Society. https://doi.org/10.1021/ja105849m

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